Enteric pathogens induce tissue tolerance and prevent neuronal loss from subsequent infections

Ahrends, Tomasz; Aydın, Begüm; Matheis, Fanny; Classon, Cajsa; Marchildon, François; Furtado, Gláucia C.; Lira, Sérgio A.; Mucida, Daniel

doi:10.1016/j.cell.2021.10.004

Cited by 61 publications

(36 citation statements)

References 50 publications

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“…In contrast, intestinal myenteric macrophages can respond rapidly to intestinal infection to limit infection-induced enteric neuronal death through the β2-adrenergic-arginase 1-polyamine axis signaling pathway [111]. Infection by different pathogens of the intestinal tract, including bacteria and parasites, induces a protective phenotype in intestinal myenteric layer macrophages, thus playing a role in protecting enteric neuronal cells and intestinal physiological functions during subsequent infections [112].…”

Section: Intestinal Neuroimmunity: How the Gut Neural Network Is Invo...mentioning

confidence: 99%

Bacterial and Viral Co-Infection in the Intestine: Competition Scenario and Their Effect on Host Immunity

Lian

Liu

et al. 2022

IJMS

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Bacteria and viruses are both important pathogens causing intestinal infections, and studies on their pathogenic mechanisms tend to focus on one pathogen alone. However, bacterial and viral co-infections occur frequently in clinical settings, and infection by one pathogen can affect the severity of infection by another pathogen, either directly or indirectly. The presence of synergistic or antagonistic effects of two pathogens in co-infection can affect disease progression to varying degrees. The triad of bacterial–viral–gut interactions involves multiple aspects of inflammatory and immune signaling, neuroimmunity, nutritional immunity, and the gut microbiome. In this review, we discussed the different scenarios triggered by different orders of bacterial and viral infections in the gut and summarized the possible mechanisms of synergy or antagonism involved in their co-infection. We also explored the regulatory mechanisms of bacterial–viral co-infection at the host intestinal immune interface from multiple perspectives.

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Section: Intestinal Neuroimmunity: How the Gut Neural Network Is Invo...mentioning

confidence: 99%

Bacterial and Viral Co-Infection in the Intestine: Competition Scenario and Their Effect on Host Immunity

Lian

Liu

et al. 2022

IJMS

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“…Studies in rats and mice supported the crosstalk of gut-innervating specialized sensory neurons (nociceptors) with microorganisms and intestinal epithelial cells to regulate the mucosal host defence 9 . Additionally, muscularis propria-resident macrophages, in close apposition with the cell bodies of enteric neurons, acquire tissue-protective phenotypes that prevented neuronal loss after infection 10 . Examination of neuro-immune crosstalk in gastrointestinal PACS should be illuminative.…”

mentioning

confidence: 99%

Gastrointestinal post-acute COVID-19 syndrome

Meringer

Mehandru

2022

Nat Rev Gastroenterol Hepatol

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“…Subsequently, the intestinal layers are then processed for flow cytometry and/or immunofluorescence analysis. For complete details on the use and execution of this profile, please refer to Ahrends et al. (2021) .…”

mentioning

confidence: 99%

“…For complete details on the use and execution of this profile, please refer to Ahrends et al. (2021) .…”

mentioning

confidence: 99%

Isolation of myenteric and submucosal plexus from mouse gastrointestinal tract and subsequent flow cytometry and immunofluorescence

2022

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Summary The myenteric plexus is located between the longitudinal and circular layers of muscularis externa in the gastrointestinal tract. It contains a large network of enteric neurons that form the enteric nervous system (ENS) and control intestinal functions, such as motility and nutrient sensing. This protocol describes the method for physical separation (peeling) of muscularis and submucosal layers of the mouse intestine. Subsequently, the intestinal layers are then processed for flow cytometry and/or immunofluorescence analysis. For complete details on the use and execution of this profile, please refer to Ahrends et al. (2021) .

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Enteric pathogens induce tissue tolerance and prevent neuronal loss from subsequent infections

Cited by 61 publications

References 50 publications

Bacterial and Viral Co-Infection in the Intestine: Competition Scenario and Their Effect on Host Immunity

Bacterial and Viral Co-Infection in the Intestine: Competition Scenario and Their Effect on Host Immunity

Gastrointestinal post-acute COVID-19 syndrome

Isolation of myenteric and submucosal plexus from mouse gastrointestinal tract and subsequent flow cytometry and immunofluorescence

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