Enteric Pathogen Testing Importance for Children with Acute Gastroenteritis: a Modified Delphi Study

Tarr, Gillian A.M.; Persson, Drew J.; Tarr, Phillip I.; Freedman, Stephen B.

doi:10.1128/spectrum.01864-22

Microbiol Spectr

2022

DOI: 10.1128/spectrum.01864-22

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Enteric Pathogen Testing Importance for Children with Acute Gastroenteritis: a Modified Delphi Study

Gillian A.M. Tarr

Drew J. Persson

Phillip I. Tarr

et al.

Abstract: Children with diarrhea and vomiting who seek care can be infected with a wide variety of infectious agents. This study reports findings from a survey of clinical, public health, and laboratory subject matter experts on the infectious agents that are most important to test for.

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Cited by 2 publications

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A gas-driven capillary based on the synergy of the catalytic and photothermal effect of PB@Au for Salmonella typhimurium detection

Gao,

Ge,

Xie

et al. 2024

Talanta

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A gas-driven capillary based on the synergy of the catalytic and photothermal effect of PB@Au for Salmonella typhimurium detection

Gao,

Ge,

Xie

et al. 2024

Talanta

View full text Add to dashboard Cite

Factors Associated With Actionable Gastrointestinal Panel Results in Hospitalized Children

Ho,

Cotter,

Thomas

et al. 2023

Hospital Pediatrics

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OBJECTIVES There is uncertainty regarding which hospitalized patients with acute gastroenteritis (AGE) benefit from gastrointestinal panel (GIP) testing. Unnecessary testing may lead to increased costs, overdiagnosis, and overtreatment. In general, AGE management and outcomes are most impacted if an actionable (bacterial or parasitic) result is obtained. We aimed to assess which clinical reasons for ordering GIP testing (“order indications”) and patient factors were associated with actionable results. METHODS This is a cross-sectional study of pediatric patients hospitalized between 2015 and 2018 at a large pediatric health care system with diarrhea and a GIP performed. Multivariable regression analysis was used to determine associations between actionable GIP results and order indication, stool frequency, and demographics. Findings were evaluated in patients with complex chronic conditions (CCC) and non-CCC patients. RESULTS There were 1124 GIPs performed in 967 encounters. Non-CCC patients had more actionable results than CCC patients, and reasons for testing differed. Across both cohorts, age ≥1 year old was positively associated with actionable results. For non-CCC patients, actionable results were associated with “diarrhea with blood or pus” order indication and nonwinter season; international travel was associated with non-Clostridioides difficile bacteria and parasites. No order indications were associated with actionable results for CCC patients. CONCLUSIONS Patient factors and order indications that may help identify children hospitalized for AGE with actionable GIP results include older age (regardless of CCC status), as well as bloody stools and international travel in previously healthy children. Prospective validation of these findings could help improve diagnostic stewardship and decrease unnecessary testing.

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Enteric Pathogen Testing Importance for Children with Acute Gastroenteritis: a Modified Delphi Study

Abstract: Children with diarrhea and vomiting who seek care can be infected with a wide variety of infectious agents. This study reports findings from a survey of clinical, public health, and laboratory subject matter experts on the infectious agents that are most important to test for.

Cited by 2 publications

References 44 publications

A gas-driven capillary based on the synergy of the catalytic and photothermal effect of PB@Au for Salmonella typhimurium detection

A gas-driven capillary based on the synergy of the catalytic and photothermal effect of PB@Au for Salmonella typhimurium detection

Factors Associated With Actionable Gastrointestinal Panel Results in Hospitalized Children

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