Enteric
            <i>Aeromonas</i>
            Infection: a Common Enteric Bacterial Infection with a Novel Infection Pattern Detected in an Australian Population with Gastroenteritis

Yuwono, Christopher; Wehrhahn, Michael C; Liu, Fang; Zhang, Li

doi:10.1128/spectrum.00286-23

Cited by 4 publications

(3 citation statements)

References 31 publications

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“…Whereas Aeromonas was identified in <1 % of the children in four African sites, it was markedly more prevalent in the Karachi (Pakistan) and Mirzapur (Bangladesh) GEMS sites, identified as a significant pathogen in 22.2 % of MSD cases [ 9 ]. Aeromonas has also been identified as the second most commonly isolated candidate enteric bacterial pathogen in children below 18 months with gastroenteritis in Australia [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Genomic analysis of clinical Aeromonas isolates reveals genetic diversity but little evidence of genetic determinants for diarrhoeal disease

Klemm,

Nisar,

Bawn

et al. 2024

Microbial Genomics

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Aeromonas spp. are associated with a number of infectious syndromes in humans including gastroenteritis and dysentery. Our understanding of the genetic diversity, population structure, virulence determinants and antimicrobial resistance of the genus has been limited by a lack of sequenced genomes linked to metadata. We performed a comprehensive analysis of the whole genome sequences of 447 Aeromonas isolates from children in Karachi, Pakistan, with moderate-to-severe diarrhoea (MSD) and from matched controls without diarrhoea that were collected as part of the Global Enteric Multicenter Study (GEMS). Human-associated Aeromonas isolates exhibited high species diversity and extensive antimicrobial and virulence gene content. Aeromonas caviae, A. dhankensis, A. veronii and A. enteropelogenes were all significantly associated with MSD in at least one cohort group. The maf2 and lafT genes that encode components of polar and lateral flagella, respectively, exhibited a weak association with isolates originating from cases of gastroenteritis.

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Section: Introductionmentioning

confidence: 99%

Genomic analysis of clinical Aeromonas isolates reveals genetic diversity but little evidence of genetic determinants for diarrhoeal disease

Klemm,

Nisar,

Bawn

et al. 2024

Microbial Genomics

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“…A recent Australian study revealed that Aeromonas spp. exhibited a distinct infection pattern in human gastroenteritis compared to other enteric bacterial pathogens [ 6 ]. Across all age groups, three infection peaks occurred in young children under four, young adults aged 20–29, and adults over 50.…”

Section: Introductionmentioning

confidence: 99%

“…In contrast, infection rates of Campylobacter spp., Salmonella spp., Shigella spp./enteroinvasive Escherichia coli and Yersinia spp. in the same age group were 320, 294, 19 and 42 per 10 000 samples, respectively [ 6 ]. Additionally, patients with inflammatory bowel disease (IBD) are more likely to be infected with Aeromonas spp.…”

Section: Introductionmentioning

confidence: 99%

Analysis of global Aeromonas caviae genomes revealed that strains carrying T6SS are more common in human gastroenteritis than in environmental sources and are often phylogenetically related

Chong,

Liu,

Yuwono

et al. 2024

Microbial Genomics

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Aeromonas caviae is an emerging human enteric pathogen. However, the genomic features and virulence genes of A. caviae strains from human gastroenteritis and other sources have not been fully elucidated. Here, we conducted a genomic analysis of 565 global A. caviae strains isolated from different sources, including 261 strains isolated from faecal samples of gastroenteritis patients, of which 18 genomes were sequenced in this study. The presence of bacterial virulence genes and secretion systems in A. caviae strains from different sources was compared, and the phylogenetic relationship of A. caviae strains was assessed based on the core genome. The complete genome of A. caviae strain A20-9 isolated from a gastroenteritis patient was obtained in this study, from which 300 putative virulence factors and a T4SS-encoding plasmid, pAC, were identified. Genes encoding T4SS were also identified in a novel genomic island, ACI-1, from other T4SS-positive strains. The prevalence of T4SS was significantly lower in A. caviae strains from gastroenteritis patients than in environmental strains (3 %, P<0.0001 vs 14 %, P<0.01). Conversely, the prevalence of T6SS was significantly higher in A. caviae strains isolated from gastroenteritis patients than in environmental strains (25 %, P<0.05 vs 13 %, P<0.01). Four phylogenetic clusters were formed based on the core genome of 565 A. caviae strains, and strains carrying T6SS often showed close phylogenetic relationships. T3SS, aerolysin and thermostable cytotonic enterotoxin were absent in all 565 A. caviae strains. Our findings provide novel information on the genomic features of A. caviae and suggest that T6SS may play a role in A. caviae-induced human gastroenteritis.

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Inhibition mechanism of crude lipopeptide from Bacillus subtilis against Aeromonas veronii growth, biofilm formation, and spoilage of channel catfish flesh

Li,

Wangjiang,

Sun

et al. 2024

Food Microbiology

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Enteric Aeromonas Infection: a Common Enteric Bacterial Infection with a Novel Infection Pattern Detected in an Australian Population with Gastroenteritis

Abstract: Aeromonas species are emerging human enteric pathogens. However, these species are currently not routinely detected in many diagnostic laboratories, and no studies have reported the detection of Aeromonas enteric infection using molecular methods.

Cited by 4 publications

References 31 publications

Genomic analysis of clinical Aeromonas isolates reveals genetic diversity but little evidence of genetic determinants for diarrhoeal disease

Genomic analysis of clinical Aeromonas isolates reveals genetic diversity but little evidence of genetic determinants for diarrhoeal disease

Analysis of global Aeromonas caviae genomes revealed that strains carrying T6SS are more common in human gastroenteritis than in environmental sources and are often phylogenetically related

Inhibition mechanism of crude lipopeptide from Bacillus subtilis against Aeromonas veronii growth, biofilm formation, and spoilage of channel catfish flesh

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