Enteric GABA‐containing nerves projecting to the guinea‐pig inferior mesenteric ganglion modulate acetylcholine release.

Parkman, HP; Stapelfeldt, Wolf H.; Williams, Christina L.; Lennon, Vanda A.; Szurszewski, Joseph H.

doi:10.1113/jphysiol.1993.sp019897

Cited by 18 publications

(14 citation statements)

References 27 publications

(43 reference statements)

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“…Within the ganglion, preganglionic fibers converge and diverge to make multiple contacts with the dendritic arbors of postganglionic neurons. This finely tuned operation relies on differences in morphology, biochemical profile, and electrophysiologic properties among ganglion cells (Gibbins, 1991;Poth et al, 1997;Gibbins et al, 2000), as well as on inputs from sensory receptors located in the viscera (Parkman et al, 1993;Hardwick et al, 1995;Miller, 2000;Quinson et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

Nicotinic mechanisms in the autonomic control of organ systems

Biasi

2002

J. Neurobiol.

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Section: Introductionmentioning

confidence: 99%

Nicotinic mechanisms in the autonomic control of organ systems

Biasi

2002

J. Neurobiol.

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“…However, Bac-induced effects on sympathetic regulation at the spinal level seem to receive little attention.In animal experiments, along the hierarchy of the neural axis, it has been shown that GABA B receptors exert multifarious effects on sympathetic regulation. Administrations of Bac may reduce catecholamine or acetylcholine release by acting on the peripheral GABA B receptors that are located presynaptically on the post-or preganglionic sympathetic nerve terminals (3,34,48,51). Intrathecal administration of Bac to the thoracic spinal cord decreases blood pressure and heart rate (33).…”

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confidence: 99%

GABA_B-receptor-mediated suppression of sympathetic outflow from the spinal cord of neonatal rats

Cheng

Ku²,

Ho³

et al. 2005

Journal of Applied Physiology

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Using a splanchnic nerve-spinal cord preparation in vitro that could spontaneously generate sympathetic nerve discharge (SND), we investigated the roles of intraspinal GABA(B) receptors in the regulation of SND. Despite an age-dependent difference in sensitivity, bath applications of baclofen (Bac; GABA(B)-receptor agonist) consistently reduced SND in a concentration-dependent manner. The drug specificity of Bac in activation of GABA(B) receptors was verified by application of its antagonist saclofen (Sac) or CGP-46381 (CGP). Sac or CGP alone did not change SND. However, in the presence of Sac or CGP, the effects of Bac on SND inhibition were reversibly attenuated. The splanchnic sympathetic preganglionic neuron (SPN) was recorded by blind whole cell, patch-clamp techniques. We examined Bac effects on electrical membrane properties of SPNs. Applications of Bac reduced excitatory synaptic events, induced membrane hyperpolarizations, and inhibited SPN firing. In the presence of 12 mM Mg2+ or 0.5 microM TTX to block Ca2+- or action potential-dependent synaptic transmissions, applications of Bac induced an outward baseline current that reversed at -29 +/- 6 mV. Because the K+ equilibrium potential in our experimental conditions was -100 mV, the Bac-induced currents could not simply be attributed to an alteration of K+ conductance. On the other hand, applications of Bac to Cs+-loaded SPNs reduced Cd2+-sensitive and high-voltage-activated inward currents, indicating an inhibition of voltage-gated Ca2+ currents. Our results suggest that the activation of intraspinal GABA(B) receptors suppresses SND via a mixture of ion events that may link to a change in Ca2+ conductance.

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“…Increases in colonic intraluminal pressure and ongoing contractile activity release neurotransmitters and neuromodulators in the IMG. Low pressure (< 10 cm H 2 O) colonic distension releases acetylcholine (ACh), 13 GABA, 14‐15 and VIP. 13 The release of SP and calcitonin gene‐related peptide (CGRP) from enpassant synapses of capsaicin‐sensitive dorsal root nerve fibers requires high pressure (> 20 cm H 2 O) colonic distension.…”

mentioning

confidence: 99%

“…16,17 Thus, prevertebral ganglia form an extended neural network that connects the lower intestinal tract to the upper gastrointestinal tract. ACh, GABA, 14,15 and a large number of peptide neuromodulators are utilized to finely tune this peripheral reflex pathway.…”

mentioning

confidence: 99%

PACAP₂₇ and Other Neuropeptides in the Inferior Mesenteric Gangliona^a

Ermilov¹,

Szurszewski²

1998

Annals of the New York Academy of Sciences

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The presence and location of PACAP27-like immunoreactivity (PACAP27-LI) in the colon-inferior mesenteric ganglion (IMG) reflex pathway and the effect of exogenously administered PACAP27 on the excitability of IMG are reported. The results provide morphological and electrophysiological support for the hypothesis that PACAP modulates reflex activity between the large intestine and IMG. The intense excitatory effect would be expected to increase the rate of action potential discharge in IMG neurons, increasing sympathetic drive to the colon thereby decreasing of colonic activity.

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Enteric GABA‐containing nerves projecting to the guinea‐pig inferior mesenteric ganglion modulate acetylcholine release.

Cited by 18 publications

References 27 publications

Nicotinic mechanisms in the autonomic control of organ systems

Nicotinic mechanisms in the autonomic control of organ systems

GABA_B-receptor-mediated suppression of sympathetic outflow from the spinal cord of neonatal rats

PACAP₂₇ and Other Neuropeptides in the Inferior Mesenteric Gangliona^a

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Enteric GABA‐containing nerves projecting to the guinea‐pig inferior mesenteric ganglion modulate acetylcholine release.

Cited by 18 publications

References 27 publications

Nicotinic mechanisms in the autonomic control of organ systems

Nicotinic mechanisms in the autonomic control of organ systems

GABAB-receptor-mediated suppression of sympathetic outflow from the spinal cord of neonatal rats

PACAP27 and Other Neuropeptides in the Inferior Mesenteric Ganglionaa

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GABA_B-receptor-mediated suppression of sympathetic outflow from the spinal cord of neonatal rats

PACAP₂₇ and Other Neuropeptides in the Inferior Mesenteric Gangliona^a