Enteric coating process of diclofenac sodium pellets in a fluid bed coater with a wurster insert: Influence of process variables on coating performance and release profile

Albanez, Roberta; Nitz, Marcello; Taranto, Osvaldir Pereira

doi:10.1016/j.apt.2012.12.003

Cited by 19 publications

(14 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The highest value of S showed PL-3 (S ¼ 0.87, Table 3) as shown in Figure 1. Spherical shape is ideal for film coating of pellets 6 .…”

Section: Resultsmentioning

confidence: 99%

“…Pellets are spherical, free flowing discreet particles with a narrow size distribution, usually varying between 500 and 1500 mm for pharmaceutical applications 5 . Pellets such as multiple unit dosage forms offer some advantages compared to single unit dosage forms such as decreased risk of irritation, dose dumping, resulting in more reproducible drug absorption 6,7 . There exists also possibility of combining several active compounds in pellets 8 , which is very important in formulating solid dosage forms from herbal extracts due to its miscellaneous composition.…”

Section: Introductionmentioning

confidence: 99%

“…Pharm Dev Technol, Early Online:[1][2][3][4][5][6] Pharmaceutical Development and Technology Downloaded from informahealthcare.com by University of Auckland on 12/01/14For personal use only.…”

mentioning

confidence: 99%

See 2 more Smart Citations

The development andin vitroevaluation of herbal pellets coated with Eudragit FS 30

Kalėdaitė

Bernatonienė

Dvořáčková

et al. 2014

Pharmaceutical Development and Technology

View full text Add to dashboard Cite

The objective of this study was to prepare pellets of thyme (Thymus vulgaris L.), stinging nettle (Urtica dioica L.) and sage (Salvia officinalis L.) dry extracts by extrusion-spheronization technique to improve technological properties and investigate dissolution profiles of pellets covered different levels of pH-sensitive polymer Eudragit® FS. Optimal sample of pellets were prepared using microcrystalline cellulose and lactose as excipients and demonstrated excellent technological quality properties such as Hausner ratio (1.07 ± 0.11) and compressibility index (6.73 ± 0.94%) value, spericity (0.87 ± 0.001) and friability (0.22 ± 0.08 N). Pellets were coated by 10-35% (w/w) of Eudragit® FS. Dissolution studies showed that less than 20% of coating could not prevent dissolution of phenols in pH 1.2, 20% Eudragit® FS coating is enough to prevent herbal extract against dissolution in the stomach. There were observed no statistical significant differences between 20% and 25% or higher amount of coating polymer to a dissolution of phenols in low pH.

show abstract

“…The highest value of S showed PL-3 (S ¼ 0.87, Table 3) as shown in Figure 1. Spherical shape is ideal for film coating of pellets 6 .…”

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The development andin vitroevaluation of herbal pellets coated with Eudragit FS 30

Kalėdaitė

Bernatonienė

Dvořáčková

et al. 2014

Pharmaceutical Development and Technology

View full text Add to dashboard Cite

show abstract

“…Processes for coating and/or surface modification have been investigated with the aim of obtaining materials with specific characteristics in order to obtain formulations with specific characteristics. Some gastro‐resistant pharmaceutical formulations slowly release the active ingredient rather than promptly after administration, allowing for a controlled released profiles . These formulations allow gastric disorder reduction, protect active principle ingredients from instability at acidic pH, and facilitate gastrointestinal tract's distal regions absorption .…”

Section: Introductionmentioning

confidence: 99%

“…Some gastro-resistant pharmaceutical formulations slowly release the active ingredient rather than promptly after administration, allowing for a controlled released profiles. 7 These formulations allow gastric disorder reduction, protect active principle ingredients from instability at acidic pH, and facilitate gastrointestinal tract's distal regions absorption. 8 Polymers for enteric coating, such as cellulose acetate phthalate or EudragitV R L, are chosen due to their ability to dissolve at different pH values.…”

Section: Introductionmentioning

confidence: 99%

Gastro‐resistant controlled release of OTC encapsulated in alginate/chitosan matrix coated with acryl‐EZE® MP in fluidized bed

Kleinubing

Seraphim

Vieira

et al. 2014

J of Applied Polymer Sci

View full text Add to dashboard Cite

A gastro‐resistant system of acryl‐EZE® MP coated alginate/chitosan microparticles was developed to improve the controlled release of oxytetracycline (OTC). Microparticles were obtained by complex coacervation and, thereafter, were coated using fluidized polymer dispersion with acryl‐EZE® MP solution. OTC distribution inside the microparticles was determined by multiphoton confocal microscopy, demonstrating the efficiency of encapsulation process. In vitro OTC release kinetic was performed in order to obtain the release profile in gastric and intestinal simulated fluids. A fast initial release, or burst effect, was observed with uncoated microparticles loaded with OTC in gastric conditions. When a 50% mass increase in acryl‐EZE® MP coating was achieved, OTC release in acidic medium was greatly reduced, resulting in the expected gastro‐resistant effect. Different mathematical models were applied to describe the drug diffusion across the polymer matrix. The Logistic model was the best tool to interpret the experimental data in most of the systems studied. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 40444.

show abstract

Sodium alginate/HPMC/liquid paraffin emulsified (o/w) gel beads, by factorial design approach; and in vitro analysis

Yadava

Patil

Mokale

et al. 2014

J Sol-Gel Sci Technol

View full text Add to dashboard Cite

Enteric coating process of diclofenac sodium pellets in a fluid bed coater with a wurster insert: Influence of process variables on coating performance and release profile

Cited by 19 publications

References 23 publications

The development andin vitroevaluation of herbal pellets coated with Eudragit FS 30

The development andin vitroevaluation of herbal pellets coated with Eudragit FS 30

Gastro‐resistant controlled release of OTC encapsulated in alginate/chitosan matrix coated with acryl‐EZE® MP in fluidized bed

Sodium alginate/HPMC/liquid paraffin emulsified (o/w) gel beads, by factorial design approach; and in vitro analysis

Contact Info

Product

Resources

About