Enteral Zinc Supplementation and Growth in Extremely‐Low‐Birth‐Weight Infants With Chronic Lung Disease

Shaikhkhalil, Ala; Curtiss, Jennifer; Puthoff, Teresa D.; Valentine, Christina J.

doi:10.1097/mpg.0000000000000145

Cited by 33 publications

(22 citation statements)

References 53 publications

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“…Recent studies have also shown that enteral zinc supplementation helps in weight gain and growth of extreme low birth weight babies. (10) In conclusion oral zinc supplementation resulted in clinically important reduction in duration and severity of diarrhoea, hence the use of zinc as adjunctive therapy has the potential to improve the management of diarrhoea and increase survival in children. It helps reduction of morbidity and mortality due to diarrhoeal disease in children in our country who are likely to be malnourished.…”

Section: Discussionmentioning

confidence: 99%

Efficacy and Effectiveness of Zinc Therapy in the Treatment of Acute Diarrhoea Among Children

Nazarullah¹,

Pillai²,

Nair³

2015

jemds

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BACKGROUND: Diarrhoea is one of the leading causes of morbidity and mortality affecting children in developing countries. We studied the efficacy of zinc therapy in reducing the duration of diarrhoea. MATERIALS AND METHODS: A double-blinded randomized control study was done in 100 children between age groups 1 month to 5 years having acute diarrhoea. These children were randomly divided into 2 groups. Group 1 received oral supplementation of 20mg zinc and ORS from day one of treatment while group 2 received only ORS therapy. Children who received zinc or antibiotics prior to the study were excluded. Clinical profile of children like age, gender, nutritional status and dehydration level was have been taken into consideration. The outcome of the study was assessed by comparing the mean number of watery stools of both the groups during the course of therapy. RESULTS: Out of 100 children based in the study 50 children in group 1 who received oral zinc supplementation showed a 36% reduction in duration of diarrhoea (6.22 days vs. 8.26 days). CONCLUSION: Zinc supplementation help reduce the duration of acute diarrhoea. KEYWORDS: Zinc, Diarrhoea. INTRODUCTION:Diarrhoeal disease is a major cause of childhood morbidity and mortality affecting millions of children worldwide. (1,2) It is estimated that more than 3 million deaths in developing countries each year is caused by diarrhoeal disease and contribute substantially to malnutrition in surviving children. (2) In accordance with the recommendations of WHO and UNICEF over the past 3 decades children of all ages including infants with acute diarrhoea of any etiology have been treated with standard oral rehydrating salt (ORS) solution. (3) Due to proven efficacy, safety and low cost, standard ORS has been widely used. Along with continued feeding, ORS has helped to bring about a decline in the fatality rate of acute dehydrating diarrhoea in children in developing countries (3). However with the use of ORS there is no reduction of stool volume, diarrhoeal duration and frequency of loose stools raising a practical problem of its acceptance and compliance. (4) Studies have reported that daily loss of zinc in the intestinal fluid during acute diarrhoea is as high as 159 mic/kg/day compared to 47 mic/kg/day in control. (5) A simple and sensitive measuring tool for zinc status is lacking, It can however be assumed that because of low bioavailability of zinc from cereal based diet (6) subclinical zinc deficiency is common in developing countries. Few children with acute diarrhoea also have lowered immunity as manifested by the absence of a cell mediated response to common antigen applied to skin. Micronutrient deficiency is the most likely explanation for this phenomenon. (7) Zinc is important for growth of intestinal mucosa and improves the transport of water and electrolytes (8) across the intestinal mucosa. Zinc also is essential in growth, protein synthesis, epithelial repair and synthesis of RNA and DNA. (9)

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Section: Discussionmentioning

confidence: 99%

Efficacy and Effectiveness of Zinc Therapy in the Treatment of Acute Diarrhoea Among Children

Nazarullah¹,

Pillai²,

Nair³

2015

jemds

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“…Accretion of micronutrient stores occurs in the third trimester . Preterm infants are therefore at risk for micronutrient deficiency and require supplementation.…”

Section: Management Of En After Bowel Resectionmentioning

confidence: 99%

Nutrition Management of Necrotizing Enterocolitis

2018

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Necrotizing enterocolitis (NEC) is one of the most significant causes of morbidity and mortality among premature infants. The exact cause is considered multifactorial and related to gastrointestinal immaturity, inflammation and enteral feeding. The role of nutrition is vitally important in NEC. The main modifiable risk factor is the introduction and advancement of enteral feedings. After an infant has recovered from NEC, enteral feeds should be cautiously resumed to prevent injury from prolonged use of parenteral nutrition. The logistics of how, when, and what to feed are somewhat unclear and often depend on the severity of the disease. For patients with an enterostomy, refeeding the distal intestine with the small-intestinal ostomy output may improve bowel growth and prevent long-term complications.

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“…Este no documenta la conocida interacción que puede haber en la absorción de cationes divalentes: hierro, zinc y cobre, por lo que parece importante mantener esta posibilidad bajo protocolos clíni-cos. Por otra parte, el suplemento de Zn en niños con DBP tratados con diuréticos mejora el crecimiento y el estado nutricional de Zn, importante de considerar en el uso crónico de diuréticos 62 .…”

Section: Suplementos Vitaminas Y Mineralesunclassified

“…Se ha documentado una maduración más rápida de la succión nutritiva, acortamiento de la hospitalización y, en algunos estudios, mejor ganancia de peso 62 . La estimulación orokinésica perioral ayuda a una transición más rápida de sonda a oral.…”

Section: Aspectos Adicionales Del Manejo Nutricionalunclassified

Nutrición intrahospitalaria del prematuro. Recomendaciones de la Rama de Neonatología de la Sociedad Chilena de Pediatría

Mena

Milad

Vernal

et al. 2016

Revista Chilena de Pediatría

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Recommendations based on current publications are presented for postnatal preterm nutrition, depending on birth weight: less 1000g, between 1000 and 1500g, and above 1500g, as well for the development periods: adaptation, stabilisation, and growth. A review is also presented on the nutritional management of morbidities that affect or may affect nutrition, such as: osteopenia, bronchopulmonary dysplasia, patent ductus arteriosus, red cell transfusion, and short bowel syndrome.

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Enteral Zinc Supplementation and Growth in Extremely‐Low‐Birth‐Weight Infants With Chronic Lung Disease

Cited by 33 publications

References 53 publications

Efficacy and Effectiveness of Zinc Therapy in the Treatment of Acute Diarrhoea Among Children

Efficacy and Effectiveness of Zinc Therapy in the Treatment of Acute Diarrhoea Among Children

Nutrition Management of Necrotizing Enterocolitis

Nutrición intrahospitalaria del prematuro. Recomendaciones de la Rama de Neonatología de la Sociedad Chilena de Pediatría

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