Enteral Nutrition Prevents Remote Organ Injury and Death After a Gut Ischemic Insult

Fukatsu, Kazuhiko; Zarzaur, Ben L.; Johnson, Corey; Lundberg, Andrew H.; Wilcox, Henry G.; Kudsk, Kenneth A.

doi:10.1097/00000658-200105000-00010

Cited by 76 publications

(50 citation statements)

References 37 publications

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“…32) Enteral nutrition has been shown to reduce death rate and remote organ injury using an animal model. 10) Demirkan et al reported the protective effect of glutamine pretreatment against intestinal I/R. 33) Fukatsu et al demonstrated that enteral feeding maintains mucosal immunity and resistance to infections.…”

Section: Discussionmentioning

confidence: 99%

“…8,9) It has been shown that enteral feeding before ischemic insults is beneficial for reducing organ injury and improving survival after intestinal I/R. 10,11) In one of those studies, the authors used a standard complex enteral diet for nutritional study, because these formulas are commercially available in clinical settings, and the authors pointed out that it is important to be aware that other nutrient formulas might improve survival after intestinal I/R. 12) The intestinal mucosa is extremely sensitive to reactive oxygen species (ROS).…”

mentioning

confidence: 99%

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Protective Effect of Soy Isoflavone Genistein on Ischemia-Reperfusion in the Rat Small Intestine

Sato

Itagaki

Oikawa

et al. 2011

Biological & Pharmaceutical Bulletin

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Ischemia-reperfusion (I/R) injury of the intestine is an important factor associated with high rates of morbidity and mortality. Intestinal I/R is a common clinical problem in the settings of severe burns, circulatory shock and strangulation ileus. Intestinal I/R damages remote organs and promotes multi-organ failure. It has been shown that enteral feeding before ischemic insults is beneficial for reducing organ injury and improving survival after intestinal I/R. In that study, the authors used a standard complex enteral diet and they suggested that it is important to find new nutrient formulas. Since reactive oxygen species are responsible for intestinal I/R injury, we focused on a dietary polyphenol, the soy isoflavone genistein. Genistein has a wide spectrum of biochemical and pharmacological activities. However, the possibility of a protective effect of genistein as enteral nutrition on I/R injury has not been investigated. We therefore investigated the protective effect of genistein on oxidative injury using intestinal I/R model rats. We found that genistein, which has combined antioxidant activity from radical scavenging, xanthine oxidase inhibition and chain-breaking effects, exhibits a protective effect on intestinal I/R injury. The results suggest that genistein, a soy isoflavone, has the possibility as a new nutrient formula of enteral feeding.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Protective Effect of Soy Isoflavone Genistein on Ischemia-Reperfusion in the Rat Small Intestine

Sato

Itagaki

Oikawa

et al. 2011

Biological & Pharmaceutical Bulletin

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“…It has also become clear that the integrity of the gut barrier is dependant on the presence of micronutrients within the gut. Parenteral nutrition is not sufficient to maintain the barrier, and this form of feeding can lead to bacterial translocation and increased risk of infection (7,17,20,21). By contrast, enteral feeding preserves TJ integrity and maintains the gut barrier.…”

mentioning

confidence: 99%

Ochratoxin A increases permeability through tight junctions by removal of specific claudin isoforms

McLaughlin

Padfield²,

Burt³

et al. 2004

American Journal of Physiology-Cell Physiology

124

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“…Recognition of the potential consequences of gastrointestinal barrier failure has prompted investigations into ways to support gastrointestinal function and integrity in critically ill patients, including the effects of route of nutrition (enteral versus parenteral), intestinal fuels (eg, glutamine, butyrate), and growth factors. [6][7][8][9] Normal digestion and absorption of nutrients occurs via carrier-mediated mechanisms or by passive diffusion. Diffusion can occur across (transcellular) or between cells (paracellular).…”

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confidence: 99%

Intestinal Permeability and Absorption in Dogs with Traumatic Injury

et al. 2002

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The objectives of this study were to assess the feasibility of using urinary recovery of sugars to evaluate intestinal permeability and absorption in dogs with traumatic injury and to determine if intestinal permeability and absorption are altered in dogs with traumatic injury. After a 6-hour fast, a sugar solution containing lactulose, rhamnose, 3-O-methyl-D-glucose, and xylose was administered via nasoesophageal tube. Urine was collected and quantitated over the 6-hour study period via closed collection urinary catheters. Urinary sugar recoveries were measured by high-pressure anion exchange liquid chromatography and pulsed amperometric detection. Urinary sugar recoveries in the trauma group at 24, 48, and 72 hours after trauma were compared to normal controls. In addition, severity of trauma was compared to urinary sugar recoveries. Twelve client-owned dogs with traumatic injury and 6 healthy controls were enrolled in the study. Lactulose recovery and the lactulose : rhamnose recovery ratio were significantly higher in the trauma group at 48 hours but were no longer different from controls by 72 hours. Xylose recovery was significantly higher in the trauma group when compared to controls at 72 hours, whereas 3-O-methyl-D-glucose recovery was significantly lower in the trauma group at 24 hours. The xylose : 3-O-methyl-D-glucose ratio was higher in the trauma group at all time points. Significant correlation was found between severity of trauma and xylose and 3-O-methyl-D-glucose recoveries 24 hours after injury. Results of this study support the hypothesis that intestinal permeability and absorption are altered in dogs with traumatic injury.

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Enteral Nutrition Prevents Remote Organ Injury and Death After a Gut Ischemic Insult

Cited by 76 publications

References 37 publications

Protective Effect of Soy Isoflavone Genistein on Ischemia-Reperfusion in the Rat Small Intestine

Protective Effect of Soy Isoflavone Genistein on Ischemia-Reperfusion in the Rat Small Intestine

Ochratoxin A increases permeability through tight junctions by removal of specific claudin isoforms

Intestinal Permeability and Absorption in Dogs with Traumatic Injury

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