Enteral Nutrition Initiation in Children Admitted to Pediatric Intensive Care Units After Traumatic Brain Injury

Balakrishnan, Binod; Flynn-OʼBrien, Katherine T.; Simpson, Pippa; Dasgupta, Mahua; Hanson, Sheila J.

doi:10.1007/s12028-018-0597-6

Cited by 16 publications

(20 citation statements)

References 24 publications

(36 reference statements)

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“…In our study the difference was 7.1 days, Haney et al 4 the difference between early and late EN was 10.7 days versus 12.9 days, and Mehta et al 11 the difference was 8.7 days versus 10.7 days. The benefits of early EN were also identified in children with cranial trauma through a multicenter study conducted by Balakrishnan et al 12 in which patients who received early nutrition (within 48 hours of admission) had lower disability at discharge and a shorter PICU-LOS of 16 days versus 20 days for those who received late EN. 14 Again, the finding of a shorter PICU-LOS is applicable to multiple geographic settings and pediatric patients with critical illness or injury.…”

Section: Discussionmentioning

confidence: 99%

Impact of Early Enteral Nutrition on the Hospital Stay of Pediatric Patients Undergoing Mechanical Ventilation

Zevallos

Jara

Ramírez

et al. 2022

J Pediatr Intensive Care

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Early initiation of enteral nutrition (EN) in pediatrics has been associated with improved clinical outcomes in critically ill pediatric patients. This research study aimed to measure the effect of early EN in intubated children on the length of stay (LOS) and days of mechanical ventilation (DMV). A retrospective cohort observational study was performed on patients admitted to the pediatric intensive care unit (PICU). We gathered the information from available medical records. Our exposure variable was EN, which can be classified as either early-onset (less than 72 hours following PICU admission) or late-onset (greater than or equal to 72 hours following PICU admission). The response variables were LOS defined as the period of time from either hospital or PICU admission to the time of hospital discharge and DMV defined as the length of time from endotracheal intubation to successful extubation. Late EN was associated with an increase in both hospital LOS consisting of 9.82 days and PICU LOS consisting of 5.89 days, and DMV consisting of 3.92 days compared with those patients receiving early EN. In addition, the disruption of EN was also associated with an increased hospital LOS consisting of 10.7 days. Patients in the PICU, undergoing mechanical ventilation, who received late EN have an increased risk of unfavorable outcomes consisting of prolonged hospital LOS, PICU-LOS, and DMV which may be further aggravated by any disruption of EN.

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Section: Discussionmentioning

confidence: 99%

Impact of Early Enteral Nutrition on the Hospital Stay of Pediatric Patients Undergoing Mechanical Ventilation

Zevallos

Jara

Ramírez

et al. 2022

J Pediatr Intensive Care

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“…Therefore, reasonable nutritional support after injury was of great significance for patients to reduce hypoproteinemia and hypermetabolic state, and to promote recovery. 11 In clinical practices, common nutritional support includes parenteral and enteral nutrition. A meta-analysis suggested that early enteral nutrition support after head injury had obvious advantages in improving the prognosis.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, reasonable nutritional support after injury was of great significance for patients to reduce hypoproteinemia and hypermetabolic state, and to promote recovery. 11 …”

Section: Discussionmentioning

confidence: 99%

Clinical observation of individualized nutritional formula on inflammation index, immune status and gastrointestinal tolerance in patients with severe head injury

Zhu

Zhang²,

Li³

et al. 2021

Pak J Med Sci

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Objectives: To evaluate the clinical significance of individualized nutritional formulas on inflammatory factors, immune status and gastrointestinal tolerance in patients with severe head injury. Methods: A total of 80 patients with severe head injury who were hospitalized in Baoding No.1 Central Hospital from March 2017 to March 2020 were randomly divided into two groups with 40 cases in each group. Patients in both groups were given enteral nutrition (EN), the control group was given conventional enteral nutrition formula through nasointestinal tube, and the experimental group was given individualized nutrition formula. All patients were tested for tumor necrosis factor (TNF-α), C-reactive protein(CRP), interleukin 6(IL-6), IgA, IgM, IgG, serum intestinal fatty acid binding protein (I-FABP) and D-lactic acid concentration before and after enteral nutrition treatment. The incidence of adverse reactions such as abdominal distension, diarrhea, constipation, and gastric retention within seven days after treatment of two groups were compared and analyzed. Results: There was no significant difference in inflammatory factors such as TNF-a, CRP, IL-6, immunoglobulin levels, I-FABP and D-lactic acid concentration between the two groups before treatment (p>0.05). After treatment, the above indicators of the two groups of patients were better than before treatment, the difference was statistically significant (p<0.05), and the experimental group was significantly better than the control group (p<0.05). The experimental group had a gastrointestinal adverse reaction rate of 10%, and the control group had 27.5%, the difference was statistically significant (p=0.04). Conclusions: Individualized nutritional formula has more significant advantages than conventional nutritional formula for patients with severe head injury, which can reduce inflammatory response, increase the patient’s immune level, improve the intestinal mucosal barrier function, have good gastrointestinal tolerance, and have a low incidence of adverse reactions. doi: https://doi.org/10.12669/pjms.37.4.3987 How to cite this:Zhu C, Zhang Y, Li W, Li Q. Clinical observation of individualized nutritional formula on inflammation index, immune status and gastrointestinal tolerance in patients with severe head injury. Pak J Med Sci. 2021;37(4):---------. doi: https://doi.org/10.12669/pjms.37.4.3987 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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“…По результатам ряда исследований было доказано, что продукция эндогенных цитокинов, ответственных за SIRS, стимулируется бактериальными эндотоксинами, которые абсорбируются кишечником, не участвующим в функции пищеварения [3,4]. Другие исследования показали снижение тяжести и частоты развития септических осложнений, у пациентов на энтеральном питании, после тяжелых механических и термических травм [5][6][7], а также после объёмных оперативных вмешательств [8]. Кроме того, результаты исследований свидетельствуют о том, что энтеральное питание поддерживает нормальную барьерную функцию кишечника, что снижает риски транслокации кишечной флоры и всасывания токсинов в кишечнике [2,7].…”

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“…Другие исследования показали снижение тяжести и частоты развития септических осложнений, у пациентов на энтеральном питании, после тяжелых механических и термических травм [5][6][7], а также после объёмных оперативных вмешательств [8]. Кроме того, результаты исследований свидетельствуют о том, что энтеральное питание поддерживает нормальную барьерную функцию кишечника, что снижает риски транслокации кишечной флоры и всасывания токсинов в кишечнике [2,7]. Учитывая вышесказанное, можно предположить, что энтеральное питание у пациентов с острым панкреатитом также снизит тяжесть и частоту развития иммунного воспалительного ответа, что в свою очередь улучшит результаты лечения.…”

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Comparison of the Effectiveness of Enteral and Parenteral Nutrition in Patients with Acute Pancreatitis

Khanko¹,

Volchenko²

2019

Ukr. ž. med. bìol. sportu

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Enteral Nutrition Initiation in Children Admitted to Pediatric Intensive Care Units After Traumatic Brain Injury

Abstract: Children with severe TBI and higher ISS were more likely to have delayed initiation of enteral nutrition. Delayed enteral nutrition was an independent risk factor for worse functional status at ICU discharge for the entire cohort, but not for the severe TBI group.

Cited by 16 publications

References 24 publications

Impact of Early Enteral Nutrition on the Hospital Stay of Pediatric Patients Undergoing Mechanical Ventilation

Impact of Early Enteral Nutrition on the Hospital Stay of Pediatric Patients Undergoing Mechanical Ventilation

Clinical observation of individualized nutritional formula on inflammation index, immune status and gastrointestinal tolerance in patients with severe head injury

Comparison of the Effectiveness of Enteral and Parenteral Nutrition in Patients with Acute Pancreatitis

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