Enteral Bioactive Factor Supplementation in Preterm Infants: A Systematic Review

Mank, Elise; Naninck, E.F.G.; Limpens, Jacqueline; Toledo, Letty van; Goudoever, Johannes B. van; Akker, Chris H.P. van den

doi:10.3390/nu12102916

Cited by 10 publications

(8 citation statements)

References 69 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Of 16 025 titles and abstracts screened, 876 full-text articles were assessed, and 154 systematic reviews evaluating 251 different research questions were included in the final umbrella review (eFigure 1 in the Supplement). The characteristics of the included systematic reviews are shown in eTable 2 in the Supplement.…”

Section: Resultsmentioning

confidence: 99%

Interventions to Prevent Bronchopulmonary Dysplasia in Preterm Neonates

et al. 2022

View full text Add to dashboard Cite

IMPORTANCE Bronchopulmonary dysplasia (BPD) has multifactorial etiology and long-term adverse consequences. An umbrella review enables the evaluation of multiple proposed interventions for the prevention of BPD. OBJECTIVE To summarize and assess the certainty of evidence of interventions proposed to decrease the risk of BPD from published systematic reviews. DATA SOURCES MEDLINE, Cochrane Central Register of Controlled Trials, EMBASE, and Web of Science were searched from inception until November 9, 2020. STUDY SELECTION Meta-analyses of randomized clinical trials comparing interventions in preterm neonates that included BPD as an outcome. DATA EXTRACTION AND SYNTHESIS Data extraction was performed in duplicate. Quality of systematic reviews was evaluated using Assessment of Multiple Systematic Reviews version 2, and certainty of evidence was assessed using Grading of Recommendation, Assessment, Development, and Evaluation. MAIN OUTCOMES AND MEASURES (1) BPD or mortality at 36 weeks' postmenstrual age (PMA) and (2) BPD at 36 weeks' PMA.RESULTS A total of 154 systematic reviews evaluating 251 comparisons were included, of which 110 (71.4%) were high-quality systematic reviews. High certainty of evidence from high-quality systematic reviews indicated that delivery room continuous positive airway pressure compared with intubation with or without routine surfactant (relative risk [RR], 0.80 [95% CI, 0.68-0.94]), early selective surfactant compared with delayed selective surfactant (RR, 0.83 [95% CI, 0.75-0.91]), early inhaled corticosteroids (RR, 0.86 [95% CI, 0.75-0.99]), early systemic hydrocortisone (RR, 0.90 [95% CI, 0.82-0.99]), avoiding endotracheal tube placement with delivery room continuous positive airway pressure and use of less invasive surfactant administration (RR, 0.90 [95% CI, 0.82-0.99]), and volume-targeted compared with pressure-limited ventilation (RR, 0.73 [95% CI, 0.59-0.89]) were associated with decreased risk of BPD or mortality at 36 weeks' PMA. Moderate to high certainty of evidence showed that inhaled nitric oxide, lower saturation targets (85%-89%), and vitamin A supplementation are associated with decreased risk of BPD at 36 weeks' PMA but not the competing outcome of BPD or mortality, indicating they may be associated with increased mortality. CONCLUSIONS AND RELEVANCEA multipronged approach of delivery room continuous positive airway pressure, early selective surfactant administration with less invasive surfactant administration, early hydrocortisone prophylaxis in high-risk neonates, inhaled corticosteroids, and volume-targeted ventilation for preterm neonates requiring invasive ventilation may decrease the combined risk of BPD or mortality at 36 weeks' PMA.

show abstract

Section: Resultsmentioning

confidence: 99%

Interventions to Prevent Bronchopulmonary Dysplasia in Preterm Neonates

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Обсуждается профилактическая роль обогащения питания детей с БЛД некоторыми витаминами, в частности А и Е [82], и микроэлементами (препараты цинка) [83].…”

Section: Clinical Phenotypes Of Malnutrition In Young Children: Diffe...unclassified

Clinical Phenotypes of Malnutrition in Young Children: Differential Nutritional Correction

Belyaeva

Бомбардирова

Prikhodko³

et al. 2023

Vopr. sovr. pediatr.

View full text Add to dashboard Cite

This review article summarizes current data on malnutrition etiology and pathogenesis in infants. Topical requirements for revealing this condition, its diagnosis and severity assessment via centile metrics are presented. The characteristics of the most common clinical phenotypes of postnatal growth insufficiency in infants (premature infants with different degree of maturation, including patients with bronchopulmonary dysplasia) are described. Differential approaches for malnutrition nutritional correction in these children are presented. The final section of the article describes special nutritional needs for children with congenital heart defects in terms of hemodynamic disorders nature and severity. Modern nutritional strategies for preparation of these patients to surgery and for their postoperative period are presented. The use of high-calorie/high-protein product for malnutrition correction in the most vulnerable patients with described in this review phenotypes is worth noticing.

show abstract

“…Vitamin A regulates the growth and differentiation of epithelial cells in the respiratory tract and is an important radical-scavenging antioxidant [ 60 , 61 ]. ELBW infants have low plasma and tissue concentrations of vitamin A, and vitamin A deficiency may predispose to BPD [ 62 ].…”

Section: Functional Nutrients With Potential Beneficial Effects On Bpdmentioning

confidence: 99%

“…Meanwhile, a systematic review and meta-analysis of four studies including 1011 preterm infants concluded that vitamin A supplementation for ELBW infants benefited oxygen dependency at 36 weeks PMA in survivors (pooled risk ratio, 0.88; 95% CI 0.77–0.99) [ 66 ]. Another systematic review and meta-analysis of three studies including 612 preterm infants assessing the effect of enteral vitamin A supplementation on BPD found a significant reduction in the incidence of BPD in the vitamin A-treated group compared to placebo (OR 0.57; 95% CI 0.24–1.35) [ 61 ].…”

Section: Functional Nutrients With Potential Beneficial Effects On Bpdmentioning

confidence: 99%

The Role of Nutrition in the Prevention and Management of Bronchopulmonary Dysplasia: A Literature Review and Clinical Approach

Rocha

Guimarães

Pereira‐da‐Silva

2021

IJERPH

View full text Add to dashboard Cite

Bronchopulmonary dysplasia (BPD) remains the most common severe complication of preterm birth, and nutrition plays a crucial role in lung growth and repair. A practical nutritional approach for infants at risk of BPD or with established BPD is provided based on a comprehensive literature review. Ideally, infants with BPD should receive a fluid intake of not more than 135‒150 mL/kg/day and an energy intake of 120‒150 kcal/kg/day. Providing high energy in low volume remains a challenge and is the main cause of growth restriction in these infants. They need a nutritional strategy that encompasses early aggressive parenteral nutrition and the initiation of concentrated feedings of energy and nutrients. The order of priority is fortified mother’s own milk, followed by fortified donor milk and preterm enriched formulas. Functional nutrient supplements with a potential protective role against BPD are revisited, despite the limited evidence of their efficacy. Specialized nutritional strategies may be necessary to overcome difficulties common in BPD infants, such as gastroesophageal reflux and poorly coordinated feeding. Planning nutrition support after discharge requires a multidisciplinary approach to deal with multiple potential problems. Regular monitoring based on anthropometry and biochemical markers is needed to guide the nutritional intervention.

show abstract

Enteral Bioactive Factor Supplementation in Preterm Infants: A Systematic Review

Cited by 10 publications

References 69 publications

Interventions to Prevent Bronchopulmonary Dysplasia in Preterm Neonates

Interventions to Prevent Bronchopulmonary Dysplasia in Preterm Neonates

Clinical Phenotypes of Malnutrition in Young Children: Differential Nutritional Correction

The Role of Nutrition in the Prevention and Management of Bronchopulmonary Dysplasia: A Literature Review and Clinical Approach

Contact Info

Product

Resources

About