Entanglement-Driven Adhesion, Self-Healing, and High Stretchability of Double-Network PEG-Based Hydrogels

Chen, Kaiwen; Feng, Yangyingfan; Zhang, Yang; Lei, Yu; Hao, Xinchang; Shao, Fei; Dou, Zhenzhen; An, Chuanfeng; Zhuang, Zhumei; Luo, Yonghao; Wang, Yi; Wu, Jinrong; Ji, Ping; Chen, Tao; Wang, Huanan

doi:10.1021/acsami.9b14348

Cited by 67 publications

(63 citation statements)

References 47 publications

(59 reference statements)

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“…[55,56] allows the encapsulation of guest molecules to form host-guest complexations. Among various candidates, the coordination between cucurbit [8] urils (Figure 5a) and dihydroxy-L-phenylalanine, cyclodextrins and adamantan cyclodextrins and ferrocene is widely adopted in healable hydrogel and adhesives. [57] Another physical adhesion lies in mechanical interlock, where interfaces are constructed via surface roughness of adherends.…”

Section: Other Types Of Physical Adhesionmentioning

confidence: 99%

“…Enzymatic-catalyzed cross-links are emerging and perspective methods in constructing a robust interface due to their lack of unwanted side reactions and reaction mildness. Integration The CB [8] host-guest interactions serve as an adhesive for two substrates. Reproduced with permission.…”

Section: Enzyme-catalyzed Crosslinkingmentioning

confidence: 99%

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confidence: 99%

“…Figure5. a) The CB[8] host-guest interactions serve as an adhesive for two substrates. Reproduced with permission [57].…”

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Recent Advances on Designs and Applications of Hydrogel Adhesives

Liu

Wang

et al. 2021

Adv Materials Inter

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extracellular matrix properties, gives them popularity in applications ranging from drug delivery, [4,5] wound dressing, [6][7][8] and tissue repair. [9,10] Various hydrogels with extraordinary properties have been reported, like tough, [11] stimuliresponse, [12] and optical variable hydrogels. [13] For example, the combination of covalently and ionically cross-linked networks endows hydrogel's excellent mechanical properties, achieving a value of 9000 J m −2 , which is comparable to natural rubber (10 000 J m −2 ). [11] Moreover, hydrogels with "self-growing" property [14] can stand duplicated stretch without ruption but gain a gradual increase in stress instead. However, in contrast to the bulk hydrogel, existing hydrogel adhesives are far from the desired properties. [15] The adhesion energy of commercial adhesives is usually ≈10 J m −2 compared to that of cartilage, composing a robust matrix of 1000 J m −2 and the adhesive layer of 800 J m −2 , respectively. [16] It is worth noting that medical and clinic adhesives should effectively prevent blood loss, gas, and tissue fluids leakage or exposure to the infectious environment or digestive fluids. [17] Thus, adhesion failure ought to result in negative therapy. Adhesion conductive hydrogels are also required to get skinlevel sensitive sensors since any interfacial vacant space will give rise to inaccurate signals. [18,19] As a result, sensors with high resolution and excellent accuracy can not be obtained under such circumstances due to "dead" regions. [20] Therefore, tough interactions between hydrogels matrix and diverse substrate, especially for wet tissues, are vital but challenging issues. [15] Of particularly significant and ideal properties for tough adhesives under stretching, dissipative energy within hydrogel matrix and interactive energy between interfaces is desired to prevent macroscopic movement. [21] By enhancing interfacial interactions via surface chemical modification, surface structuralizing, physical interlocks, or combining the principles mentioned above, a series of adhesive patches or tough adhesives with injectable, tunable curing time, degradable properties have been obtained.Numerous synthetic or natural materials, diverse design strategies, various methods, and many potential applications have emerged. In this review, as shown in Figure 1, we will summarize the state-of-art hydrogel adhesives spanning from design principles, including physical and chemical interactions In virtue of extracellular features, hydrogels have been used in various areas such as tissue repair, artificial skins, and biological electronics, etc. Intact contact of tough hydrogels to targeted surfaces is usually required to avoid blood or body fluids leakage or inaccurate signals of sensors. The collaboration of high interactive energy between interfaces and high fracture toughness of the constituent hydrogels can effectively prevent relatively macroscopic motions of adhesives from substrates under deformation. Nevertheless, variations in surface microenvironment...

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Section: Other Types Of Physical Adhesionmentioning

confidence: 99%

Section: Enzyme-catalyzed Crosslinkingmentioning

confidence: 99%

“…

…”

mentioning

confidence: 99%

“…Figure5. a) The CB[8] host-guest interactions serve as an adhesive for two substrates. Reproduced with permission [57].…”

mentioning

confidence: 99%

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Recent Advances on Designs and Applications of Hydrogel Adhesives

Liu

Wang

et al. 2021

Adv Materials Inter

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“…Gong et al . proposed double-network (DN) hydrogel, which typically combines a stable covalent network with a reversible non-covalent network, and has shown mechanical strength and toughness values orders of magnitude greater than what the can achieve separately[ 12 - 15 ]. Inspired by this concept, our group has developed DN hydrogels based on reversibly crosslinked colloidal network combined with a continuous phase of the permanently crosslinked network by covalent bonds.…”

Section: Introductionmentioning

confidence: 99%

Elastic and Stretchable Double Network Hydrogel as Printable Ink for High-Resolution Fabrication of Ionic Skin

Chen

Ying

Hao

et al. 2021

ijb

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A hydrogel that combines both printability and adaptability, high elasticity, and stretchability can provide ideal mechanical properties, and also render complex and accurate construction for ionic skin. However, it is extremely challenging. Here, we propose a colloidal-based double-network (DN) hydrogel as printable inks for high-precision fabrication of ionic skins. Particularly, polyacrylamide (PAAm), as the covalent network that can maintain the long-term material integrity, was combined with gelatin colloidal network to improve the injectability and printability of the resulting DN hydrogels. The DN design cooperatively provides the hydrogels with higher toughness values and deformability than what single colloidal or PAAm network can achieve. Further design of ionic skin based on capacitor microarray was demonstrated to serve as a sensitive and stable capacitor that can respond to external stimuli, thereby allowing to sense the body movements such as finger bending, laugh, and wrist pulse by translating mechanical changes into electric signals. Therefore, this study provides a novel strategy for the design and preparation of high-resolution ionic skins as the wearable sensor.

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