2018
DOI: 10.1002/1873-3468.13012
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Entangled signal pathways can both control expression stability and induce stochastic focusing

Abstract: Gene transcription is often controlled by multiple interacting signal pathways, but how these pathways impact gene expression is not fully understood. Here, we refine a mechanic model based on experiments in murine embryonic stem cells and analyze the influence of pathway-pathway cross-talk strength (CTS) on mRNA expression stability. We find that the CTS can tune this stability, depending on the manner of regulation. Furthermore, there is an optimal CTS such that the expression pattern is most stable but free… Show more

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Cited by 3 publications
(2 citation statements)
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References 66 publications
(116 reference statements)
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“…The posttranscriptional regulation process can be studied at a global level by analyzing the gene regulatory network to identify key regulators that are important in different regulatory pathways 20,21,22 . At 23 a more abstract level, we can also study quantitatively how the regulator can modify the gene expression level with given reaction scheme and parameters 24,25,26,23 , which is the focus of this paper.…”
Section: Introductionmentioning
confidence: 99%
“…The posttranscriptional regulation process can be studied at a global level by analyzing the gene regulatory network to identify key regulators that are important in different regulatory pathways 20,21,22 . At 23 a more abstract level, we can also study quantitatively how the regulator can modify the gene expression level with given reaction scheme and parameters 24,25,26,23 , which is the focus of this paper.…”
Section: Introductionmentioning
confidence: 99%
“…Feedback can be negative and positive; here, we shall specifically focus on positive feedback on burst size. The impact of negative feedback on burst size and burst frequency has been investigated in [8,9] Models of stochastic gene expression are typically based on the random telegraph framework [10][11][12][13][14][15][16][17]. In a random telegraph model, a gene can be either in an On state or in an Off state, transitioning randomly in time between the two.…”
Section: Introductionmentioning
confidence: 99%