Entamoeba histolytica depresses chemiluminescence in stimulated human polymorphonuclear leukocytes

Al-Mofleh, Ibrahim; Al-Tuwaijri, Ali S.; Mahmoud, Ahmed; Alam, Mahabubul

doi:10.1016/0192-0561(89)90182-3

Cited by 5 publications

(2 citation statements)

References 38 publications

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“…Additionally, several enzymes of E. histolytica can inhibit the oxidative response of neutrophils [ 4 , 8 , 104 ]. For instance, neutrophils have an iron-containing superoxide dismutase [ 18 , 19 ] and a bifunctional NADPH flavin oxidoreductase [ 21 ] that transform superoxide anions to H 2 O 2 .…”

Section: Defense Mechanisms Of Amebasmentioning

confidence: 99%

A review of the proposed role of neutrophils in rodent amebic liver abscess models

et al. 2016

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Host invasion by Entamoeba histolytica, the pathogenic agent of amebiasis, can lead to the development of amebic liver abscess (ALA). Due to the difficulty of exploring host and amebic factors involved in the pathogenesis of ALA in humans, most studies have been conducted with animal models (e.g., mice, gerbils, and hamsters). Histopathological findings reveal that the chronic phase of ALA in humans corresponds to lytic or liquefactive necrosis, whereas in rodent models there is granulomatous inflammation. However, the use of animal models has provided important information on molecules and mechanisms of the host/parasite interaction. Hence, the present review discusses the possible role of neutrophils in the effector immune response in ALA in rodents. Properly activated neutrophils are probably successful in eliminating amebas through oxidative and non-oxidative mechanisms, including neutrophil degranulation, the generation of free radicals (O2−, H2O2, HOCl) and peroxynitrite, the activation of NADPH-oxidase and myeloperoxidase (MPO) enzymes, and the formation of neutrophil extracellular traps (NETs). On the other hand, if amebas are not eliminated in the early stages of infection, they trigger a prolonged and exaggerated inflammatory response that apparently causes ALAs. Genetic differences in animals and humans are likely to be key to a successful host immune response.

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Section: Defense Mechanisms Of Amebasmentioning

confidence: 99%

A review of the proposed role of neutrophils in rodent amebic liver abscess models

et al. 2016

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“…Regard to the pathophysiology, new evidences regard the interaction between E. histolytica and human polymorphonuclear neutrophils (PMN) has been investigated, based on in vitro and in vivo animal studies, which have found that PMN actively migrate toward amebae trophozoite cells (Al-Mofleh, et al 1989;Arbo, et al 1993 ;Guerrant, et al 1981). Later studies in tissue culture systems demonstrated that PMN were confirmed to play a vital role in amebic tissue invasion mechanisms (Accolla, 2006;Arbo, et al 1993).…”

Section: Pathologymentioning

confidence: 99%