Entacapone scavenges peroxynitrite and protects against kidney and liver injuries induced by renal ischemia/reperfusion in rats

Soliman, Eman; Shewaikh, Samar M.; Fahmy, Aly A.; Elshazly, Shimaa M.

doi:10.1007/s11255-021-02827-5

Cited by 4 publications

(2 citation statements)

References 37 publications

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“…In addition, the role of Cat is relatively insignificant at low H 2 O 2 concentrations but becomes a significant role at high H 2 O 2 concentrations (Gandhi and Sasikumar, 2012). Improving Cu, Zn-SOD can neutralize O 2 • − excess before reacting with •NO to form peroxynitrite (ONOO−), a strong oxidant that can damage the cells by several mechanisms (Forman and Zhang, 2021;Soliman et al, 2021). In similar research, Wresdiyati et al (2010) found that Momordica charantia L. powder increased Cu, Zn-SOD content of the liver and kidney in oxidative stress in diabetic rats.…”

Section: Discussionmentioning

confidence: 99%

Nanoextract of Acalypha hispida leaves increases antioxidant defense and suppresses microstructure damage in liver and kidney of diabetic rats

Alfarisi¹,

Wresdiyati²,

Sa’diah³

et al. 2022

j app pharm sci

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Nanotechnology has rapidly grown in various research fields, including phytomedicine to treat oxidative stress in diabetes. This study aimed to evaluate the effect of the nanoextract of Acalypha hispida leaves on antioxidant defense and microstructure of the liver and kidney in diabetic rats. A total of 24 rats were divided into 6 groups (n = 4): normal rats, diabetic rats, and diabetic rats treated with metformin at 88 mg/kg, extract at 300 mg/kg, and nanoextract at 30 and 60 mg/kg body weight (BW). BW, blood biochemistry (alanine aminotransferase, aspartate aminotransferase, urea, and creatinine), total superoxide dismutase (SOD), catalase (Cat), and malondialdehyde (MDA) were evaluated. Histomorphological and immunohistochemical (Cu, Zn-SOD) analyses were observed in the liver and kidney. The extract and nanoextract of A. hispida improved blood biochemistry in diabetic rats. Both decreased MDA level and increased total SOD and Cat activity in the liver and kidney of diabetic rats. Cu, Zn-SOD contents of the liver and kidney in the extract and nanoextract-treated diabetic were higher than in the diabetic control. The nanoextract at 60 mg/kg BW showed the best effect in suppressing microstructure damage to the liver and kidney. The study concluded that the nanoextract of A. hispida leaves increased antioxidant defense and suppressed microstructure damage in the liver and kidney of diabetic rats.

show abstract

Section: Discussionmentioning

confidence: 99%

Nanoextract of Acalypha hispida leaves increases antioxidant defense and suppresses microstructure damage in liver and kidney of diabetic rats

Alfarisi¹,

Wresdiyati²,

Sa’diah³

et al. 2022

j app pharm sci

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show abstract

“…As superoxide levels increase with reperfusion, higher production of NO may be detrimental over time, given its ability to react with superoxide to form peroxynitrite. This potent reactive oxygen species has been shown to be detrimental in IRI, as it impairs mitochondrial function, increases inflammation, and disrupts DNA structure [30]. Furthermore, genetic deletion of eNOS has been demonstrated to limit renal injury in the setting of ischemia-reperfusion, as assessed by lower blood creatinine levels, immune cell infiltration and nitrotyrosine staining of injured kidneys in eNOS knockout mice [7].…”

Section: Discussionmentioning

confidence: 99%

Deletion of the Gamma Subunit of ENaC in Endothelial Cells Does Not Protect against Renal Ischemia Reperfusion Injury

Mutchler

Hasan

Kohan

et al. 2021

IJMS

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Acute kidney injury due to renal ischemia-reperfusion injury (IRI) may lead to chronic or end stage kidney disease. A greater understanding of the cellular mechanisms underlying IRI are required to develop therapeutic options aimed at limiting or reversing damage from IRI. Prior work has shown that deletion of the α subunit of the epithelial Na+ channel (ENaC) in endothelial cells protects from IRI by increasing the availability of nitric oxide. While canonical ENaCs consist of an α, β, and γ subunit, there is evidence of non-canonical ENaC expression in endothelial cells involving the α subunit. We therefore tested whether the deletion of the γ subunit of ENaC also protects mice from IRI to differentiate between these channel configurations. Mice with endothelial-specific deletion of the γ subunit and control littermates were subjected to unilateral renal artery occlusion followed by 48 h of reperfusion. No significant difference was noted in injury between the two groups as assessed by serum creatinine and blood urea nitrogen, levels of specific kidney injury markers, and histological examination. While deletion of the γ subunit did not alter infiltration of immune cells or cytokine message, it was associated with an increase in levels of total and phosphorylated endothelial nitric oxide synthase (eNOS) in the injured kidneys. Our studies demonstrate that even though deletion of the γ subunit of ENaC may allow for greater activation of eNOS, this is not sufficient to prevent IRI, suggesting the protective effects of α subunit deletion may be due, in part, to other mechanisms.

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Reno- and hepato-protective effect of allopurinol after renal ischemia/reperfusion injury: Crosstalk between xanthine oxidase and peroxisome proliferator-activated receptor gamma signaling

Soliman

Elshazly

Shewaikh

et al. 2023

Food and Chemical Toxicology

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Entacapone scavenges peroxynitrite and protects against kidney and liver injuries induced by renal ischemia/reperfusion in rats

Cited by 4 publications

References 37 publications

Nanoextract of Acalypha hispida leaves increases antioxidant defense and suppresses microstructure damage in liver and kidney of diabetic rats

Nanoextract of Acalypha hispida leaves increases antioxidant defense and suppresses microstructure damage in liver and kidney of diabetic rats

Deletion of the Gamma Subunit of ENaC in Endothelial Cells Does Not Protect against Renal Ischemia Reperfusion Injury

Reno- and hepato-protective effect of allopurinol after renal ischemia/reperfusion injury: Crosstalk between xanthine oxidase and peroxisome proliferator-activated receptor gamma signaling

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