Ent-kauranes from the Chinese Excoecaria agallocha L. and NF-κB inhibitory activity

Jiang, Zhongping; Zou, Binhua; Li, Xiaojuan; Liu, Junjun; Shen, Li; Wu, Jun

doi:10.1016/j.fitote.2019.01.007

Cited by 5 publications

(4 citation statements)

References 25 publications

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“…Moreover, it also showed NF-κB pathway inhibitory effect. Agallochanin K from Excoecaria agallocha [154,167] showed a similar activity of NF-κB pathway inhibition (Table 2). Hispidulin was also reported from the Chinese C. inerme [105], but it was not tested for anti-inflammatory activity.…”

Section: Flavonoidsmentioning

confidence: 86%

“…From the roots of Thai Brucea javanica, seven quassinoids (brujavanol A and B, bruceine, 11-dehydroklaineanone, 15β-hydroxyklaineanone, 14,15β-dihydroxyklaineanone, 15β-Oacetyl-14hydroxyklaieanone [69]. Agallolides I and J from Excoecaria agallocha [154,167] showed a similar inhibitory effect on the NF-κB pathway (Table 2). Some isolated terpenoids also interrupted inflammations induced by activated RIG-I-like receptors and NOD-like receptors (NLRs) in the cytoplasm.…”

Section: Terpenes and Terpenoidsmentioning

confidence: 94%

“…The plant is known for healing skin cancer [32]. [145]; Excoecarins R1 and R2 [146]; 3α,11β-Dihydroxy-ent-isopimara-8( 14),15-dien-2-one, 16β-Hydroxy-ent-atisan-3-one, Ribenone, ent-labda-8( 17),13E-diene-3β,15-diol, ent-3β-Hydroxybeyer-15-ene-2,12-dione [147]; Excoecarins S, T1-T2, ent-12-oxo-2,3-Secobeyer-15-ene-2,3-dioic acid, ent-15-epoxy-Beyerane-3α-ol, Agallochin H [148]; Excoecarins V1-V3, 3,5,7,3 ,5 -Pentahydroxy-2R,3R-flavanonol [150,151]; Excoagallochaols A-E [152]; Agallochins A-E [153,154]; Excoecarins D, E, and K [155]; Agallochins J-L [154,156]; Agallochins F-I, 2-Acetoxy-1,15-beyeradiene-3,12-dione, 2-Hydroxy-1,15-beyeradiene-3,12-dione, ent-kauran-16β-ol-3-one [148,154,157]; Excoecariphenols A-D [158]; Agallochaols K-P, Agallochaol Q, ent-17-Hydroxykaur-15-en-3-one, ent-Kaur-15-en-3β,17-diol, 7-Deoxogeayine, ent-15-Hydroxylabd-8( 17),13E-dien-3-one, ent-15,18-Dihydroxylabd-8( 17),13E-diene, ent-3β,11α-Dihydroxyisopimara-8( 14),15-dien-2-one, ent-3β-Hydroxybeyer-15-en-2,12-dione [159]; ent-16α-Hydroxy-atisane-3,4-lactone, ent-16α-Hydroxy-atisane-3-one, ent-Atisane-3β,16α-diol, ent-3,4-seco-16α-Hydroxyatis-4(19)-en-3-oic acid [160]; Triacontane [161]; Agallochins M-P [159,162,163]; Excagallonoid A, ent-(3α,5β,8α,9β,10α,12α)-3-Hydroxyatis-16-en-14-one, Atis-16-ene-3,14-dione, 2-Hydroxy-atis-1,16-diene-3,14-dione, 12-Hydroxy-13-methylpodocarpa-8,11,13-trien-3-one [164]; Excolides A-B [165] An aqueous leaf infusion is taken orally to heal internal pains, such as toothache; the liquid is applied to skin sores [42,168].…”

Section: Euphorbia Tirucalli L (Euphorbiaceae)mentioning

confidence: 99%

“…Suppressed the expression of NF-κB and activator protein-1 (AP-1) targeted genes and TNF-α and IL-6 LPS-activated Raw 264.7 cells [154,159,167].…”

Section: Excoecaria Agallocha Ntmentioning

confidence: 99%

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Indigenous Uses, Phytochemical Analysis, and Anti-Inflammatory Properties of Australian Tropical Medicinal Plants

Yeshi

Turpin

Jamtsho³

et al. 2022

Molecules

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Australian tropical plants have been a rich source of food (bush food) and medicine to the first Australians (Aboriginal people), who are believed to have lived for more than 50,000 years. Plants such as spreading sneezeweed (Centipeda minima), goat’s foot (Ipomoea pes-caprae), and hop bush (Dodonaea viscosa and D. polyandra) are a few popular Aboriginal medicinal plants. Thus far, more than 900 medicinal plants have been recorded in the tropical region alone, and many of them are associated with diverse ethnomedicinal uses that belong to the traditional owners of Aboriginal people. In our effort to find anti-inflammatory lead compounds in collaboration with Aboriginal communities from their medicinal plants, we reviewed 78 medicinal plants used against various inflammation and inflammatory-related conditions by Aboriginal people. Out of those 78 species, we have included only 45 species whose crude extracts or isolated pure compounds showed anti-inflammatory properties. Upon investigating compounds isolated from 40 species (for five species, only crude extracts were studied), 83 compounds were associated with various anti-inflammatory properties. Alphitolic acid, Betulinic acid, Malabaric acid, and Hispidulin reduced proinflammatory cytokines and cyclooxygenase enzymes (COX-1 and 2) with IC50 values ranging from 11.5 to 46.9 uM. Other promising anti-inflammatory compounds are Brevilin A (from Centipeda minima), Eupalestin, and 5′-methoxy nobiletin (from Ageratum conyzoides), Calophyllolide (from Calophyllum inophyllum), and Brusatol (from Brucea javanica). D. polyandra is one example of an Aboriginal medicinal plant from which a novel anti-inflammatory benzoyl ester clerodane diterpenoid compound was obtained (compound name not disclosed), and it is in the development of topical medicines for inflammatory skin diseases. Medicinal plants in the tropics and those associated with indigenous knowledge of Aboriginal people could be a potential alternative source of novel anti-inflammatory therapeutics.

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Section: Flavonoidsmentioning

confidence: 86%