Ensuring the operational health of droplet-based microelectrofluidic biosensor systems

Su, Fei; Ozev, Sule; Chakrabarty, Krishnendu

doi:10.1109/jsen.2005.848127

Cited by 74 publications

(4 citation statements)

References 21 publications

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“…through capillary bridge shape modeling. Several EWOD experiments [15][16][17][18][19] that utilized capacitance measurement method were developed in the past decade. However, the systems discussed in these works contain dielectric layers that are relatively thick (~μm).…”

Section: Introductionmentioning

confidence: 99%

Impedance spectroscopy and electrical modeling of electrowetting on dielectric devices

Mibus

Knospe

et al. 2015

J. Micromech. Microeng.

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Using impedance spectroscopy, we have determined models for the elements which determine the ac electrical behavior in electrowetting on dielectric (EWOD) systems. Three commonly used EWOD electrode configurations were analyzed. In each case, the impedance can be modeled by a combination of elements, including the solution resistance, the capacitance of the dielectric layer, and the constant phase impedance of the electrode double layers. The sensitivity of the system's impedance to variations in the electrowetted area is also analyzed for these common configurations. We also demonstrate that the impedance per unit area of typical EWOD systems is invariant to bias voltage.

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Section: Introductionmentioning

confidence: 99%

Impedance spectroscopy and electrical modeling of electrowetting on dielectric devices

Mibus

Knospe

et al. 2015

J. Micromech. Microeng.

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“…This kind of small platform or LC can gather the whole laboratory activities into a chip format. Nowadays, MFB for biomedical activities are receiving much attractive (SU et al , 2006; SU et al , 2005). These chips, also known as LC or BMEMS, offer several advantages over usual laboratory procedures.…”

Section: Introductionmentioning

confidence: 99%

A technique of a “lab-on-a-chip” for developing a novel biosensor in viewpoint of health-care (PHC) applications and biological regulator sensors

Monajjemi,

Mollaamin

2024

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Purpose Recently, powerful instruments for biomedical engineering research studies, including disease modeling, drug designing and nano-drug delivering, have been extremely investigated by researchers. Particularly, investigation in various microfluidics techniques and novel biomedical approaches for microfluidic-based substrate have progressed in recent years, and therefore, various cell culture platforms have been manufactured for these types of approaches. These microinstruments, known as tissue chip platforms, mimic in vivo living tissue and exhibit more physiologically similar vitro models of human tissues. Using lab-on-a-chip technologies in vitro cell culturing quickly caused in optimized systems of tissues compared to static culture. These chipsets prepare cell culture media to mimic physiological reactions and behaviors. Design/methodology/approach The authors used the application of lab chip instruments as a versatile tool for point of health-care (PHC) applications, and the authors applied a current progress in various platforms toward biochip DNA sensors as an alternative to the general bio electrochemical sensors. Basically, optical sensing is related to the intercalation between glass surfaces containing biomolecules with fluorescence and, subsequently, its reflected light that arises from the characteristics of the chemical agents. Recently, various techniques using optical fiber have progressed significantly, and researchers apply highlighted remarks and future perspectives of these kinds of platforms for PHC applications. Findings The authors assembled several microfluidic chips through cell culture and immune-fluorescent, as well as using microscopy measurement and image analysis for RNA sequencing. By this work, several chip assemblies were fabricated, and the application of the fluidic routing mechanism enables us to provide chip-to-chip communication with a variety of tissue-on-a-chip. By lab-on-a-chip techniques, the authors exhibited that coating the cell membrane via poly-dopamine and collagen was the best cell membrane coating due to the monolayer growth and differentiation of the cell types during the differentiation period. The authors found the artificial membrane, through coating with Collagen-A, has improved the growth of mouse podocytes cells-5 compared with the fibronectin-coated membrane. Originality/value The authors could distinguish the differences across the patient cohort when they used a collagen-coated microfluidic chip. For instance, von Willebrand factor, a blood glycoprotein that promotes hemostasis, can be identified and measured through these type-coated microfluidic chips.

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“…A work which is related to digital biochips has also been presented, where techniques for test planning, fault classification, and test optimization were proposed [19]. The main and soft fault have been identified and detected by tracking the motion of droplets using an RC oscillator [20]- [21]. The open structure of the digital array can be easily reconfigured to avoid the defected cells and run a biochemical sensing operation and fault recognition scheme simultaneously.…”

Section: Introductionmentioning

confidence: 99%

Self-diagnostic approach for cell counting biosensor

Al-Gayem

Jaafar

Hreshee

2021

IJEECS

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<span id="docs-internal-guid-66699b2e-7fff-5c7e-3931-5de920908f42"><span>In this research, a test monitoring strategy for an array of biosensors is proposed. The principle idea of this diagnostic technique is to measure and compare the impedance of each sensor in the array to achieve fully controlled online health monitoring technique at the system level. The work includes implementation of the diagnostic system, system architecture for analogue part, and SNR analysis. The technique has been applied on a cell coulter counting biochip where the design and fabrication of this sensing chip with electrodes make the coulter counter be an effective mean to count and analyses the cells in a blood sample. The experimental results show that the indication factor of the sensing electrodes has increased from 1 to 1.8 gradually depending on the fault level.</span></span>

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Ensuring the operational health of droplet-based microelectrofluidic biosensor systems

Cited by 74 publications

References 21 publications

Impedance spectroscopy and electrical modeling of electrowetting on dielectric devices

Impedance spectroscopy and electrical modeling of electrowetting on dielectric devices

A technique of a “lab-on-a-chip” for developing a novel biosensor in viewpoint of health-care (PHC) applications and biological regulator sensors

Self-diagnostic approach for cell counting biosensor

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