ENSA expression correlates with attenuated tumor propagation in liver cancer

Chen, Yao Li; Kuo, Ming Han; Lin, Ping; Chuang, Wan Ling; Hsu, Chia Chen; Chu, Pei Yi; Lee, Chia-Huei; Huang, Tim H-M.; Leu, Yu Wei; Hsiao, Shu Huei

doi:10.1016/j.bbrc.2013.10.165

Cited by 10 publications

(6 citation statements)

References 33 publications

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“…Overexpression of ENSA has been reported to have no proliferative or invasive phenotype in breast cancer cells ( Vera et al, 2015 ) and surprisingly it suppresses tumor growth in liver cells ( Chen et al, 2013 ). These contradictory results combined with the general lack of effect seen in patient data (Figure 1D ), suggests that ENSA overexpression is likely to be biologically inert in most cell types and requires activation or inhibition by MASTL or other upstream kinases such as CDK1 and PKA ( Mochida, 2014 ).…”

Section: Effects Of Ensa Overexpressionmentioning

confidence: 99%

The Oncogenic Functions of MASTL Kinase

Marzec

Burgess

2018

Front. Cell Dev. Biol.

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MASTL kinase is a master regulator of mitosis, essential for ensuring that mitotic substrate phosphorylation is correctly maintained. It achieves this through the phosphorylation of alpha-endosulfine and subsequent inhibition of the tumor suppressor PP2A-B55 phosphatase. In recent years MASTL has also emerged as a novel oncogenic kinase that is upregulated in a number of cancer types, correlating with chromosome instability and poor patient survival. While the chromosome instability is likely directly linked to MASTL’s control of mitotic phosphorylation, several new studies indicated that MASTL has additional effects outside of mitosis and beyond regulation of PP2A-B55. These include control of normal DNA replication timing, and regulation of AKT/mTOR and Wnt/β-catenin oncogenic kinase signaling. In this review, we will examine the phenotypes and mechanisms for how MASTL, ENSA, and PP2A-B55 deregulation drives tumor progression and metastasis. Finally, we will explore the rationale for the future development of MASTL inhibitors as new cancer therapeutics.

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Section: Effects Of Ensa Overexpressionmentioning

confidence: 99%

The Oncogenic Functions of MASTL Kinase

Marzec

Burgess

2018

Front. Cell Dev. Biol.

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“…Surprisingly, although ENSA amplification and upregulation is observed in tumoral samples (cBioportal database), it has not been strongly linked with cancer patient outcomes, with only one study reporting the hypomethylation of the ENSA gene promoter and the overexpression of this protein in liver cancer cell lines and patient samples. Contrary to Arpp19, this overexpression was linked with tumor suppression [111].…”

Section: Arpp19 and Ensa Misregulation In Cancermentioning

confidence: 68%

PP2A-B55 Holoenzyme Regulation and Cancer

et al. 2020

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Protein phosphorylation is a post-translational modification essential for the control of the activity of most enzymes in the cell. This protein modification results from a fine-tuned balance between kinases and phosphatases. PP2A is one of the major serine/threonine phosphatases that is involved in the control of a myriad of different signaling cascades. This enzyme, often misregulated in cancer, is considered a tumor suppressor. In this review, we will focus on PP2A-B55, a particular holoenzyme of the family of the PP2A phosphatases whose specific role in cancer development and progression has only recently been highlighted. The discovery of the Greatwall (Gwl)/Arpp19-ENSA cascade, a new pathway specifically controlling PP2A-B55 activity, has been shown to be frequently altered in cancer. Herein, we will review the current knowledge about the mechanisms controlling the formation and the regulation of the activity of this phosphatase and its misregulation in cancer.

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“…The overexpressed ENSA is correlated to the growth of suppressor tumors concern. (Chen et al, 2013). MDM2 is also an important role in tumor progression (MDM2-P53 Pathway in Hepatocellular Carcinoma | Cancer Research, 2014).…”

Section: Resultsmentioning

confidence: 99%

Identification of Potential Gene Expression in Hepatitis B Virus-induced Liver Cancer Using the Simulated Annealing Algorithm

Muflikhah¹,

Widodo²,

Mahmudy³

et al. 2021

Preprint

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BackgroundLiver cancer is often associated with hepatitis B infection, and there is a progression from chronic hepatitis to hepatocellular carcinoma. The replication of the virus affects the cell cycle of the host. Many oncogenes that express themselves in the formation of proteins can be highly expressed. A microarray technique can be used as a high throughput measure to determine gene expression in the mechanism of hepatoma progression. However, it has lacks important information on the potential genes to trigger the disease. The information is about the produced mRNA and has a difference to the normal cell line as control. ResultsThis study aimed to identify the potential genes that could be used as predictors to detect liver cancer using a heuristic algorithm, simulated annealing optimization. The basic idea of this algorithm was to overcome the combinatorial problem using probability values to select the significant features as a predictor for the classifier model in the representative machine learning algorithms, such as SVM, KNN, Naïve Bayes. C5.0 Decision Tree, and Random Forest. The experimental results showed quite high performance, more than 90% on average. However, using the simulated annealing algorithm requires substantial computation time to identify genes that could be used for detecting liver cancer.Conclusion A large amount of gene expression data can be reduced by identifying the potential gene as a predictor in the liver cancer mechanism. Using simulated annealing optimization, the experiment result obtained almost all the selected gene belongs to the type of protein-coding in liver tumor progression. Using cross-validation, the result achieved high performance even though the required time for selection is higher than classification using the machine learning method.

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ENSA expression correlates with attenuated tumor propagation in liver cancer

Cited by 10 publications

References 33 publications

The Oncogenic Functions of MASTL Kinase

The Oncogenic Functions of MASTL Kinase

PP2A-B55 Holoenzyme Regulation and Cancer

Identification of Potential Gene Expression in Hepatitis B Virus-induced Liver Cancer Using the Simulated Annealing Algorithm

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