Enrollment and biospecimen collection in a multiethnic family cohort: the Northern California site of the Breast Cancer Family Registry

John, Esther M.; Sangaramoorthy, Meera; Koo, Jocelyn; Whittemore, Alice S.; West, Dee W.

doi:10.1007/s10552-019-01154-6

Cited by 14 publications

(18 citation statements)

References 53 publications

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“…Our excellent rates of collection of salivary DNA and nine saliva samples are comparable to biospecimen collection rates in studies that included principles of CBPR to specifically address the issue of low minority representation in research studies (1,27,43,44). Similar to others, our use of CBPR methods and in-depth knowledge of the community were effective recruitment strategies for biomedical research (45,46).…”

Section: Discussionsupporting

confidence: 69%

Participant-Centered Strategies for Overcoming Barriers to Biospecimen Collection among Spanish-Speaking Latina Breast Cancer Survivors

Samayoa

Santoyo‐Olsson

Escalera

et al. 2020

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Latinos are underrepresented in biomedical research, particularly biomarker research, yet they constitute the nation's largest ethnic/racial minority. Optimal methods for obtaining biospecimens for biomarker research among Latinos need to be identified. To minimize barriers and enhance participation, this study developed and tested tailored strategies for collecting biomarkers of chronic stress and premature aging among Spanishspeaking Latina breast cancer survivors.Methods: This study used a community-based participatory approach and selected hair and saliva as noninvasive biospecimens to assess telomere length, the cortisol awakening response (CAR), and hair cortisol concentration. We developed bilingual multimedia instructional materials, and community health workers assisted in collections. Telephone surveys assessed willingness to participate in future studies, barriers to sample collection, and recommendations for improving the strategies.Results: A total of 103 participants were recruited over 18 months from two rural sites in California, and 88 were retained at 6-month follow-up. At baseline, rates of donating salivary DNA for telomere length measurement, saliva for CAR analysis, and hair for cortisol concentration were 98%, 89%, and 52%, respectively. At follow-up, rates were 83%, 76%, and 55%, respectively. The majority of participants reported being very willing to provide hair (72%) or saliva (74%) for future studies.Conclusions: Our results support the feasibility of including minorities in biomedical research. We report excellent rates of saliva collection when community partners are engaged in the process, and when patient-centered and culturally tailored recruitment methods are implemented.Impact: The development of methods to facilitate the inclusion of minorities in biomedical research is critical to eliminate racial/ ethnic health disparities.

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Section: Discussionsupporting

confidence: 69%

Participant-Centered Strategies for Overcoming Barriers to Biospecimen Collection among Spanish-Speaking Latina Breast Cancer Survivors

Samayoa

Santoyo‐Olsson

Escalera

et al. 2020

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…NC-BCFR enrolled nearly 3,700 population-based breast cancer families of whom 75% are racial/ethnic minorities (22). The Institutional Review Boards of the Cancer Prevention Institute of California and Stanford University approved the study and participants provided written informed consent.…”

Section: Study Populationmentioning

confidence: 99%

“…The Institutional Review Boards of the Cancer Prevention Institute of California and Stanford University approved the study and participants provided written informed consent. Details on the study design are provided elsewhere (22). Briefly, a total of 34,517 women ages 18 to 64 years newly diagnosed with breast cancer were ascertained through the Greater San Francisco Bay Area Cancer Registry (diagnoses 1995-2009) and the Sacramento and Sierra Cancer Registries (diagnoses 2005-2006), which are part of the California Cancer Registry (Fig.…”

Section: Study Populationmentioning

confidence: 99%

“…We compared the family history reports of 1,716 probands to the personal cancer history reports of 3,136 enrolled female first-degree relatives. This analysis included only a subset of all enrolled probands since not all enumerated relatives were alive, resided in North America, had proband permission to be contacted, or enrolled in NC-BCFR (22). For this comparison, we grouped melanoma and other types of skin cancer under the category skin cancer, as reports of melanoma are often not distinguished from other skin cancers.…”

Section: Comparisons Of Cancer History Datamentioning

confidence: 99%

“…We examined the accuracy of first-degree family history of breast and other cancers reported by African American, Asian American, Hispanic white, and non-Hispanic white women with breast cancer enrolled in the Northern California Breast Cancer Family Registry (NC-BCFR; refs. 22,23).…”

Section: Introductionmentioning

confidence: 99%

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Race/Ethnicity and Accuracy of Self-Reported Female First-Degree Family History of Breast and Other Cancers in the Northern California Breast Cancer Family Registry

John

Canchola

Sangaramoorthy

et al. 2019

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Few studies have evaluated accuracy of selfreported family history of breast and other cancers in racial/ ethnic minorities.Methods: We assessed the accuracy of cancer family history reports by women with breast cancer (probands) from the Northern California Breast Cancer Family Registry compared with 2 reference standards: personal cancer history reports by female first-degree relatives and California Cancer Registry records.Results: Probands reported breast cancer in first-degree relatives with high accuracy, but accuracy was lower for other cancers. Sensitivity (percentage correctly identifying relatives with cancer) was 93% [95% confidence interval (CI), 89.5-95.4] when compared with the relatives' self-report of breast cancer as the reference standard and varied little by proband race/ethnicity and other demographic factors, except for marginally lower sensitivity for Hispanic white probands (87.3%; 95% CI, 78.0-93.1; P ¼ 0.07) than non-Hispanic white probands (95.1%; 95% CI, 88.9-98.0). Accuracy was also high when compared with cancer registry records as the reference standard, with a sensitivity of 95.5% (95% CI, 93.4-96.9) for breast cancer, but lower sensitivity for Hispanic white probands (91.2%; 95% CI, 84.4-95.2; P ¼ 0.05) and probands with low English language proficiency (80%; 95% CI, 52.8-93.5; P < 0.01).Conclusions: Non-Hispanic white, African American, and Asian American probands reported first-degree breast cancer family history with high accuracy, although sensitivity was lower for Hispanic white probands and those with low English language proficiency. Impact: Self-reported family history of breast cancer in first-degree relatives is highly accurate and can be used as a reliable standard when other validation methods are not available.

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Cumulative menstrual months and breast cancer risk by hormone receptor status and ethnicity: The Breast Cancer Etiology in Minorities Study

Cole

John

Hines

et al. 2021

Intl Journal of Cancer

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Reproductive and hormonal factors may influence breast cancer risk via endogenous estrogen exposure. Cumulative menstrual months (CMM) can be used as a surrogate measure of this exposure. Using harmonized data from four population‐based breast cancer studies (7284 cases and 7242 controls), we examined ethnicity‐specific associations between CMM and breast cancer risk using logistic regression, adjusting for menopausal status and other risk factors. Higher CMM was associated with increased breast cancer risk in non‐Hispanic Whites, Hispanics and Asian Americans regardless of menopausal status (all FDR adjusted P trends = .0004), but not in African Americans. In premenopausal African Americans, there was a suggestive trend of lower risk with higher CMM. Stratification by body mass index (BMI) among premenopausal African American women showed a nonsignificant positive association with CMM in nonobese (BMI <30 kg/m2) women and a significant inverse association in obese women (OR per 50 CMM = 0.56, 95% CI 0.37‐0.87, Ptrend = .03). Risk patterns were similar for hormone receptor positive (HR+; ER+ or PR+) breast cancer; a positive association was found in all premenopausal and postmenopausal ethnic groups except in African Americans. HR− (ER− and PR−) breast cancer was not associated with CMM in all groups combined, except for a suggestive positive association among premenopausal Asian Americans (OR per 50 CMM = 1.33, P = .07). In summary, these results add to the accumulating evidence that established reproductive and hormonal factors impact breast cancer risk differently in African American women compared to other ethnic groups, and also differently for HR− breast cancer than HR+ breast cancer.

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Enrollment and biospecimen collection in a multiethnic family cohort: the Northern California site of the Breast Cancer Family Registry

Cited by 14 publications

References 53 publications

Participant-Centered Strategies for Overcoming Barriers to Biospecimen Collection among Spanish-Speaking Latina Breast Cancer Survivors

Participant-Centered Strategies for Overcoming Barriers to Biospecimen Collection among Spanish-Speaking Latina Breast Cancer Survivors

Race/Ethnicity and Accuracy of Self-Reported Female First-Degree Family History of Breast and Other Cancers in the Northern California Breast Cancer Family Registry

Cumulative menstrual months and breast cancer risk by hormone receptor status and ethnicity: The Breast Cancer Etiology in Minorities Study

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