Enrofloxacin/florfenicol loaded cyclodextrin metal-organic-framework for drug delivery and controlled release

Abstract

We presented an antibiotic-loaded c-cyclodextrin metal-organic framework that delivered antibiotics suitable for the treatment of bacterial infections. The c-cyclodextrin metal-organic framework was developed using c-cyclodextrin and potassium ion via the ultrasonic method. The antibiotic (florfenicol and enrofloxacin) was primarily encapsulated into the pore structures of c-CD-MOF, which allowed the sustained release of antibiotics over an extended period of time in vitro and in vivo. Notably, antibiotics-loaded c-CD-MOF showed much superior activity against bacteria than free antibiotics (lower MIC value) and displayed better long-lasting activity (longer antibacterial time). The antibiotics-loaded c-CD-MOF showed nontoxic and perfect biocompatibility to mammalian cells and tissues both in vitro and in vivo. These materials thus represent a novel drug-delivery device suitable for antibiotic therapy. This research is of great significance for reducing the generation of bacterial resistance and providing new ideas for the application of c-CD-MOF.

Research Progress in the Preparation of Enrofloxacin for Use in Veterinary Medicine

“…Furthermore, enrofloxacin can also be targeted to macrophages using nanoliposomes and thereby effectively treating intracellular bacterial infections (Meng et al, 2020). Drug delivery systems based on the carrier skeleton structures can also be used to deliver targeted drugs (Lai et al, 2013) and γ-cyclodextrin skeletons loaded with potassium ions and enrofloxacin were also successful targeted-delivery vehicles (Wei et al, 2021).…”

Cyclodextrin metal–organic frameworks and derivatives: recent developments and applications

“…160 A few interesting studies on the loading and delivery of some novel drugs (via CD-MOFs) such as Enrofloxacin/florfenicol, Triptolide, Myricetin and Iodine, have been published, too. 111,[196][197][198] Furthermore, novel strategies have been proposed to ensure the sustained release of drugs. For instance, the controlled and sustained release of indomethacin (IMC) was achieved by its loading on CD-MOF and subsequent encapsulation of the drug loaded CD-MOF in Eudragit s RS polymer by spray drying.…”

Cyclodextrin Inclusion Complexes with Antibiotics and Antibacterial Agents as Drug-Delivery Systems—A Pharmaceutical Perspective

“…In another approach, a γ-CD metal-organic framework (MOF) loaded with enrofloxacin and FF was prepared [ 131 ]. The γ-CD-MOF was prepared via an ultrasonic method to obtain small particles.…”