The purpose of this study was to determine the effect of self-efficacy, computer anxiety, trait anxiety, and cognitive distortions on student interest in learning Mind Your Own Business (MYOB). This research is a quantitative study using raw data obtained from questionnaires and data analysis in this study used multiple linear regression and data collection techniques in the form of questionnaires in this study. The data obtained were analyzed by f-test, t-test, and multiple linear regression analysis. The results showed that partially the self-efficacy variable affected students' interest in learning MYOB, computer anxiety had an effect on student interest in learning MYOB, trait anxiety had an effect on students' interest in learning MYOB, and cognitive distortions had an effect on students' interest in learning MYOB. The practical implication of this research is that important to ensure that students have good self-efficacy, low anxiety levels, and no cognitive deviations in them.