Enrichment of glycoRNAs using galactose oxidase, hydrazide chemistry, and glycosidase digestion
Xinyu Miao,
Jianbo Deng,
Xiaotong Wang
et al.
Abstract:Ribonucleic acid (RNA), essential for protein production and immune function, undergoes glycosylation, a process that attaches carbohydrates to RNA, creating unique glycoRNAs. These sugar-coated RNA molecules regulate immune responses and may be related to immune disorders. However, studying them is challenging due to RNA’s fragility. Therefore, a robust method for identifying glycosylated RNA is important. To address this, we optimized methods for enriching and identifying glycoRNAs, opening doors to explore … Show more
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