“…Studies have shown that C. pachystachya has anti‐inflammatory, cardiotonic, sedative and antioxidant properties (Aragão et al, ; Consolini, Ragone, Migliori, Conforti, & Volonté, ; Hikawczuk, Saad, Guardia, Juarez, & Giordano, ). We have been determining the potential of C. pachystachya in the central nervous system as an antidepressant‐like agent, by studying the effect of the crude extract at 200 and 400 mg/kg in mice submitted to chronic unpredictable stress (Gazal et al, ) and of EFF‐ Cp at 50 and 100 mg/kg in rats subjected to chronic mild stress (Ortmann et al, ). In fact, the achievement of an enriched flavonoid fraction allowed a reduction in the active dose, at four times, assigning technological advantages.…”