Enriched environment induces angiogenesis and improves neural function outcomes in rat stroke model

Yu, Kewei; Wu, Yi; Zhang, Qi; Xie, Haiyang; Liu, Gang; Guo, Zhiliang; Li, Fang; Jia, Jie; Kuang, Shenyi; Hu, Ruiping

doi:10.1016/j.jns.2014.10.022

Cited by 58 publications

(36 citation statements)

References 39 publications

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“…Indeed, it was reported that the stimulation of the dentate nucleus in rodents positively affected post-stroke motor recovery [84]. Zhang and colleagues demonstrated that the effectiveness of environmental enrichment, known to promote rehabilitation [85], is facilitated when paired with cerebellar stimulation. To obtain the stimulation specificity, they photo-activated the DCN, previously injected with rAAV-hsyn-hChR2-mcherry-WPRE-PA.…”

Section: Movement Disordersmentioning

confidence: 99%

The Optogenetic Revolution in Cerebellar Investigations

Prestori

Montagna

D’Angelo

et al. 2020

IJMS

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The cerebellum is most renowned for its role in sensorimotor control and coordination, but a growing number of anatomical and physiological studies are demonstrating its deep involvement in cognitive and emotional functions. Recently, the development and refinement of optogenetic techniques boosted research in the cerebellar field and, impressively, revolutionized the methodological approach and endowed the investigations with entirely new capabilities. This translated into a significant improvement in the data acquired for sensorimotor tests, allowing one to correlate single-cell activity with motor behavior to the extent of determining the role of single neuronal types and single connection pathways in controlling precise aspects of movement kinematics. These levels of specificity in correlating neuronal activity to behavior could not be achieved in the past, when electrical and pharmacological stimulations were the only available experimental tools. The application of optogenetics to the investigation of the cerebellar role in higher-order and cognitive functions, which involves a high degree of connectivity with multiple brain areas, has been even more significant. It is possible that, in this field, optogenetics has changed the game, and the number of investigations using optogenetics to study the cerebellar role in non-sensorimotor functions in awake animals is growing. The main issues addressed by these studies are the cerebellar role in epilepsy (through connections to the hippocampus and the temporal lobe), schizophrenia and cognition, working memory for decision making, and social behavior. It is also worth noting that optogenetics opened a new perspective for cerebellar neurostimulation in patients (e.g., for epilepsy treatment and stroke rehabilitation), promising unprecedented specificity in the targeted pathways that could be either activated or inhibited.

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Section: Movement Disordersmentioning

confidence: 99%

The Optogenetic Revolution in Cerebellar Investigations

Prestori

Montagna

D’Angelo

et al. 2020

IJMS

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“…Angiogenesis is important for neurological recovery after stroke. 27,28 To examine the effect of the vascular endothelial growth factor (VEGF)/VEGFR2 signaling pathway on neurological function, we detected atrophy volumes and neurobehavioral outcomes 3 weeks after brain ischemia. Atrophy volume was increased in the SU5416treated mice compared to the MMP-9-treated mice (7.71 ± 0.64 mm 3 in the MMP-9 group versus 12.91 ± 1.03 mm 3 in the MMP-9 + SU group or 14.80 ± 1.29 mm 3 in the SU-alone group, p < 0.01, Figures 7A-7C).…”

Section: Mmp-9 Improvement Of Neurobehavioral Outcomes Was Dependent mentioning

confidence: 99%

Hypoxia Response Element-Regulated MMP-9 Promotes Neurological Recovery via Glial Scar Degradation and Angiogenesis in Delayed Stroke

Cai

Jiang

et al. 2017

Molecular Therapy

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Matrix metalloproteinase 9 (MMP-9) plays a beneficial role in the delayed phase of middle cerebral artery occlusion (MCAO). However, the mechanism is obscure. Here, we constructed hypoxia response element (HRE)-regulated MMP-9 to explore its effect on glial scars and neurogenesis in delayed ischemic stroke. Adult male Institute of Cancer Research (ICR) mice underwent MCAO and received a stereotactic injection of lentivirus carrying HRE-MMP-9 or normal saline (NS)/lentivirus-GFP 7 days after ischemia. We found that HRE-MMP-9 improved neurological outcomes, reduced ischemia-induced brain atrophy, and degraded glial scars (p < 0.05). Furthermore, HRE-MMP-9 increased the number of microvessels in the peri-infarct area (p < 0.001), which may have been due to the accumulation of endogenous endothelial progenitor cells (EPCs) in the peri-infarct area after glial scar degradation. Finally, HRE-MMP-9 increased the number of bromodeoxyuridine-positive (BrdU)/NeuN cells and the expression of PSD-95 in the peri-infarct area (p < 0.01). These changes could be blocked by vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor SU5416 and MMP-9 inhibitor 2-[[(4-phenoxyphenyl)sulfonyl]methyl]-thiirane (SB-3CT). Our results provided a novel mechanism by which glial scar degradation and vascular endothelial growth factor (VEGF)/VEGFR2-dependent angiogenesis may be key procedures for neurological recovery in delayed ischemic stroke after HRE-MMP-9 treatment. Therefore, HRE-MMP-9 overexpression in the delayed ischemic brain is a promising approach for neurological recovery.

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“…Enriching the sensory environment can accelerate development (Schwartz et al, 2011;Liu et al, 2012), improve recovery from injury (Baroncelli et al, 2012;Yu et al, 2014), and increase performance of learning and memory (Falkenberg et al, 1992). However, it is less clear how enrichment of spontaneous activity, especially during periods when environmentally evoked activity is absent, influences the organization and maturation of the nervous system.…”

Section: Introductionmentioning

confidence: 99%

Increasing Spontaneous Retinal Activity before Eye Opening Accelerates the Development of Geniculate Receptive Fields

Davis¹,

Chapman²,

Cheng³

2015

J. Neurosci.

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Visually evoked activity is necessary for the normal development of the visual system. However, little is known about the capacity for patterned spontaneous activity to drive the maturation of receptive fields before visual experience. Retinal waves provide instructive retinotopic information for the anatomical organization of the visual thalamus. To determine whether retinal waves also drive the maturation of functional responses, we increased the frequency of retinal waves pharmacologically in the ferret (Mustela putorius furo) during a period of retinogeniculate development before eye opening. The development of geniculate receptive fields after receiving these increased neural activities was measured using single-unit electrophysiology. We found that increased retinal waves accelerate the developmental reduction of geniculate receptive field sizes. This reduction is due to a decrease in receptive field center size rather than an increase in inhibitory surround strength. This work reveals an instructive role for patterned spontaneous activity in guiding the functional development of neural circuits.

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Enriched environment induces angiogenesis and improves neural function outcomes in rat stroke model

Cited by 58 publications

References 39 publications

The Optogenetic Revolution in Cerebellar Investigations

The Optogenetic Revolution in Cerebellar Investigations

Hypoxia Response Element-Regulated MMP-9 Promotes Neurological Recovery via Glial Scar Degradation and Angiogenesis in Delayed Stroke

Increasing Spontaneous Retinal Activity before Eye Opening Accelerates the Development of Geniculate Receptive Fields

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