Enriched bovine IgG fraction prevents infections with Enterohaemorrhagic Escherichia coli O157:H7, Salmonella enterica serovar Enteritidis, and Mycobacterium avium

Abstract

A bovine IgG‐enriched whey fraction contains antibodies against various bacterial antigens. We investigated the protective effects of a bovine whey fraction preparation against infections with Enterohaemorrhagic Escherichia coli O157:H7, Salmonella enterica serovar Enteritidis, and Mycobacterium avium in mouse models. After infection with these pathogens, the IgG‐enriched fraction or skim milk was given ad libitum at a 5% solution instead of water. The mice given the IgG‐enriched fraction were significantly resistant to orally challenged EHEC O157:H7 (LD 50 : 4.0 × 10 5 CFU/mouse) infections compared with the mice given skim milk (LD 50 : <1.5 × 10 2 CFU/mouse). The mice given the IgG‐enriched fraction were also significantly resistant to orally challenged S. Enteritidis (LD 50 : 5.0 × 10 6 CFU/mouse) infections compared with the mice given skim milk (LD 50 : <2.5 × 10 1 CFU/mouse). When the mice were nasally infected with M. avium , the numbers of the bacteria in lungs of mice given the IgG‐enriched fraction were significantly lower than those given skim milk 2 and 3 weeks after infection. These results strongly indicate that oral administration of the bovine IgG‐enriched whey fraction protects mice against food‐borne infection and also that it partially protects mice against respiratory tract infection.

Insights into the Research Trends on Bovine Colostrum: Beneficial Health Perspectives with Special Reference to Manufacturing of Functional Foods and Feed Supplements

“…Additional studies are needed to better understand the mechanism behind the immunomodulatory action. The oral administration of BC IgG-enriched whey fractions (IgG25+) has the potential to protect against food-borne infections ( Salmonella enterica serovar Enteritidis, Enterohaemorrhagic Escherichia coli O1 57:H7, Mycobacterium avium ) and was also found to be partially effective against respiratory tract infection in mice [ 120 ]. Sanctuary et al [ 30 ] reported that the supplementation of bovine colostrum oligosaccharides with Bifidobacterium longum subspecies Infanti 0.3 g twice/day for 12 weeks to children of age 2–11 years suffering from gastrointestinal symptoms and autism disorders results in improvement of gastrointestinal (GI) symptoms and is well-tolerated with a mild gassiness as a common side effect.…”

Presence of antibodies against SARS-CoV-2 spike protein in bovine whey IgG enriched fraction

“…Several reports that indicate bovine IgG has antibodies against various bacterial antigens and activates the human immune system to repel pathogens have been reviewed ( Ulfman et al, 2018 ). Bovine IgG fraction was reported to protect mice against food-borne infections with enterohaemorrhagic E. coli O157:H7 and Salmonella enterica serovar Enteritidis ( Funatogawa et al, 2019 ). This IgG fraction partially protected mice against respiratory tract infection with Mycobacterium avium (Funatogawa, Tada, Kuwahara-arai, Kirikae, & Takahashi, 2019).…”