ENPP1, premier exemple d’un déterminant génétique commun à l’obésité et au diabète de type 2

Meyre, David; Froguel, Philippe

doi:10.1051/medsci/2006223308

Med Sci (Paris)

2006

DOI: 10.1051/medsci/2006223308

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ENPP1, premier exemple d’un déterminant génétique commun à l’obésité et au diabète de type 2

David Meyre

Philippe Froguel²

Abstract: . L'apparition récente de cas de DT2 chez les adolescents et même chez certains enfants est directement corrélée avec l'explosion de la prévalence de l'obésité infantile [5]. Cependant, tous les obèses ne deviennent pas diabétiques. Comme le DT2 a lui-même une base génétique, l'existence de déterminants moléculaires communs entre obésité et DT2 a été postulée depuis longtemps mais jamais vraiment étayée. Ainsi les formes monogéniques de DT2 (diabète MODY) ne sont pas accompagnées d'obésité, et les formes mendé… Show more

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Genome-wide scan for adiposity-related phenotypes in adults from American Samoa

et al. 2007

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Objective: To detect quantitative trait loci influencing adiposity-related phenotypes assessed by body mass index (BMI), abdominal circumference (ABDCIR), percent body fat (%BFAT) and fasting serum leptin and adiponectin using a whole genome linkage scan of families from American Samoa. Design: Family-based linkage analysis, the probands and family members were unselected for obesity. Subjects: A total of 583 phenotyped American Samoan adults, of which 578 were genotyped in 34 pedigrees. Measurements: A total of 377 autosomal and 18 X chromosome microsatellite markers were typed at an approximate average spacing of 10 cM spanning the genome. Multipoint LOD (logarithm of the odds) scores were calculated using variancecomponents approaches and SOLAR/LOKI software. The covariates simultaneously evaluated were age, sex, education, farm work and cigarette smoking, with a significance level of 0.1. Due to the stochastic nature of LOKI, we report the average of maximum LOD scores from 10 runs. Results: Significant linkage to leptin was found at 6q32.2 with LOD of 3.83. Suggestive linkage to leptin was found at 16q21:LOD ¼ 2.98, 1q42.2:LOD ¼ 1.97, 5q11.2:LOD ¼ 2.08, 12q24.23:LOD ¼ 2.00, 19p13.3:LOD ¼ 2.05; adiponectin was linked to 13q33.1-q22.1:LOD ¼ 2.41; %BFAT was linked to 16q12.2-q21, LOD ¼ 2.24; ABDCIR was linked to 16q23.1:LOD ¼ 1.95; %BFAT-adjusted leptin to 14q12, LOD ¼ 2.01; %BFAT-adjusted ABDCIR to 1q31.1, LOD ¼ 2.36, to 3q27.3-q28, LOD ¼ 2.10 and to 12p12.3, LOD ¼ 2.04. Conclusion: We found strong evidence for a major locus on 6q23.2 influencing serum leptin levels in American Samoans. The 16q21 region appears to harbor a susceptibility locus that has significant pleiotrophic effects on phenotypes BMI, %BFAT, leptin and ABDCIR as shown by bivariate linkage analyses. Several other loci of varying significance were detected across the genome.

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Genome-wide scan for adiposity-related phenotypes in adults from American Samoa

et al. 2007

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Correlation of obesity and the novel adipocytokines, leptin and adiponectin with insulin resistance in type 2 diabetes

Das

Bandyopadhyay

Biswas

et al. 2014

Bangladesh J Physiol Pharmacol

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Back ground: Type 2 Diabetes mellitus is state of uncompensated insulin resistance. But what actually predisposes to it, is still a controversy. Obesity is often marked as a precondition for such insulin resistance. But the degree of association and mode of pathogenesis are grossly debated. Methods:Here we explored the correlation of physical parameters for obesity like BMI (Body Mass Index), abdominal circumference, waist-hip ratio and the adipocytokines like leptin and adiponectin with the degree of insulin resistance (HOMA-IR score) in 167 patients of type 2 Diabetes mellitus. Result:We found significant positive correlation between BMI, abdominal circumference, waisthip ratio and insulin resistance. Leptin showed significant positive correlation with all the said physical parameters. But, adiponectin showed a negative correlation with abdominal circumference, waist-hip ratio and fasting insulin. Leptin-adiponectin ratio showed a significant positive correlation with insulin resistance. Conclusion:Leptin shoots up with increased adiposity where as adiponectin gets reduced in central obesity which may contribute to insulin resistance. Though neither of leptin and adiponectin showed any significant correlation with insulin resistance individually, a significant positive correlation was found between leptin and adiponectin ratio and HOMA -IR score. Therefore, the ratio can be an authentic predictor of insulin resistance as it takes into account the interplay of both of the adipocytokines for its causation.

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ENPP1, premier exemple d’un déterminant génétique commun à l’obésité et au diabète de type 2

Cited by 2 publications

References 26 publications

Genome-wide scan for adiposity-related phenotypes in adults from American Samoa

Genome-wide scan for adiposity-related phenotypes in adults from American Samoa

Correlation of obesity and the novel adipocytokines, leptin and adiponectin with insulin resistance in type 2 diabetes

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