Enoxaparin Plus Compression Stockings Compared With Compression Stockings Alone in the Prevention of Venous Thromboembolism After Elective Neurosurgery

Agnelli, Giancarlo; Piovella, Franco; Buoncristiani, P; Severi, Paolo; Pini, M; D’Angelo, Armando; Beltrametti, Chiara; Damiani, Marcello; Andrioli, Gian Carlo; Pugliese, Raffaelino; Iorio, Alfonso; Brambilla, G.

doi:10.1097/00006254-199811000-00013

Cited by 43 publications

(67 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Patients in that study received LMWH (nadroparin) and graduated compression stockings, and by venography were found to have a proximal lower extremity incidence of 7%; however, the incidence of total lower extremity DVT was considerably higher at 19% [14]. Similarly, Agnelli et al demonstrated an incidence of 5% proximal and 17% total lower extremity DVT, in patients treated with both LMWH (enoxaparin) and compression stockings as detected by venography at treatment day 8 (or sooner if the patient developed symptoms of DVT confirmed by compression ultrasound) [8]. Both of these studies revealed a significant reduction in the rate of DVT when combined prophylactic regimens were employed.…”

Section: Discussionmentioning

confidence: 95%

“…The optimal method of VTE prophylaxis in neurosurgical patients is a matter of controversy. The landmark 1998 study by Agnelli et al demonstrated the superiority of combined pharmacologic and mechanical prophylaxis over mechanical methods alone in neurosurgical patients, reducing the risk of VTE from 33 to 17% [8]. Several subsequent studies have similarly reported lower rates of VTE with multimodality prophylaxis [9,10].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The incidence of deep vein thrombosis detected by routine surveillance ultrasound in neurosurgery patients receiving dual modality prophylaxis

Henwood

Kennedy

Thomson

et al. 2011

J Thromb Thrombolysis

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

The incidence of deep vein thrombosis detected by routine surveillance ultrasound in neurosurgery patients receiving dual modality prophylaxis

Henwood

Kennedy

Thomson

et al. 2011

J Thromb Thrombolysis

View full text Add to dashboard Cite

“…1 Two double-blind, randomized, venography-based studies compared graduated compression stockings alone or a combination of graduated elastic stockings and LMWH started postoperatively in neurosurgical patients. 78,79 In the first trial, the rates of overall DVT and proximal DVT were 26% and 12% in patients given graduated compression stockings alone and 19% and 7%, respectively, in those given the stockings plus LMWH. 78 In the second study, the rates of overall and proximal DVT were 33% and 13% in the group wearing graduated compression stockings compared with 17% and 5%, respectively, in patients receiving the combined prophylaxis.…”

Section: Neurosurgerymentioning

confidence: 99%

“…78 In the second study, the rates of overall and proximal DVT were 33% and 13% in the group wearing graduated compression stockings compared with 17% and 5%, respectively, in patients receiving the combined prophylaxis. 79 Therefore, prophylaxis with the combination of LMWH and graduated compression stockings is more efficacious than prophylaxis with the stockings alone. Pooled results from randomized trials in neurosurgery patients found that the rates of intracranial bleeding were 2.1% in the patients receiving postoperative LMWH and 1.1% in those who had mechanical or no prophylaxis.…”

Section: Neurosurgerymentioning

confidence: 99%

Prevention of Venous Thromboembolism in Surgical Patients

2004

Self Cite

View full text Add to dashboard Cite

Abstract-Venous thromboembolism (VTE) is a common complication of surgical procedures. The risk for VTE in surgical patients is determined by the combination of individual predisposing factors and the specific type of surgery. Prophylaxis with mechanical and pharmacological methods has been shown to be effective and safe in most types of surgery and should be routinely implemented. For patients undergoing general, gynecologic, vascular, and major urologic surgery, low-dose unfractionated heparin or low-molecular-weight heparin (LMWH) are the options of choice. For low-risk urologic surgery, early postoperative mobilization of patients is the only intervention warranted. For higher-risk patients, including those undergoing elective hip or knee replacement and surgery for hip fracture, vitamin K antagonists, LMWH, or fondaparinux are recommended. For patients undergoing neurosurgery, graduated elastic stockings are effective and safe and may be combined with LMWH to further reduce the risk of VTE. The role of prophylaxis is less defined in patients undergoing elective spine surgery, as well as laparoscopic and arthroscopic surgery. A number of issues related to prophylaxis of VTE after surgery deserve further clarification, including the role of screening for asymptomatic deep vein thrombosis, the best timing for initiation of pharmacological prophylaxis, and the optimal duration of prophylaxis in high-risk patients. Key Words: venous thromboembolism Ⅲ deep vein thrombosis Ⅲ pulmonary embolism Ⅲ heparin Ⅲ low-molecular-weight heparin Ⅲ vitamin K antagonists

show abstract

“…Intermittent pneumatic compression (IPC) and compression stockings are the most common forms of mechanical prophylaxis for VTE [79]. In a systematic meta-analysis, Vanek et al demonstrated that IPC decreased the risk of DVT by 62% compared to a placebo, 47% compared to high-pressure stockings, and 48% compared to low molecular weight heparin [80].…”

Section: Mechanicalmentioning

confidence: 99%

Venous Thromboembolism in Brain Tumor Patients: A Review of Literature

Coté¹,

Smith

2015

J Hematol Thrombo Dis

View full text Add to dashboard Cite

Venous thromboembolism (VTE) is a relatively common and well-described condition, affecting approximately 1-2% of the general population. VTE can lead to significant morbidity and death via pulmonary embolism (PE). During the post-operative period, VTE occurs at higher rates due to natural thrombotic responses to injury and limited post-operative mobility. In general, rates of post-operative VTE are higher in patients undergoing operations for cranial and spinal lesions than for lesions of other types, a phenomenon that is not fully explained. Several studies have demonstrated that other risk factors for VTE include age, sex, ethnicity, hospital stay length, and coagulation state. Aggressive chemical and mechanical measures for VTE prophylaxis are indicated in the postoperative period to prevent the formation of VTE. Here we review the literature on VTE in brain tumor patients, with a focus on their etiology, diagnosis, treatment, and prophylaxis.

show abstract

Enoxaparin Plus Compression Stockings Compared With Compression Stockings Alone in the Prevention of Venous Thromboembolism After Elective Neurosurgery

Cited by 43 publications

References 0 publications

The incidence of deep vein thrombosis detected by routine surveillance ultrasound in neurosurgery patients receiving dual modality prophylaxis

The incidence of deep vein thrombosis detected by routine surveillance ultrasound in neurosurgery patients receiving dual modality prophylaxis

Prevention of Venous Thromboembolism in Surgical Patients

Venous Thromboembolism in Brain Tumor Patients: A Review of Literature

Contact Info

Product

Resources

About