Abstract:Spinal cord injury (SCI) is a highly debilitating condition that impairs neuronal function and triggers a complex cascade of primary and secondary damage events. Autophagy can result in cell death, which is a phenomenon in eukaryotic cells and plays an important role in the development of SCI. Thus, this provides a practical and potential target for therapeutic intervention against SCI. Enolase inhibition (ENOblock) has been demonstrated to provide neuroprotection and functional recovery in a rat model of SCI.… Show more
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