ENO1, a potential prognostic head and neck cancer marker, promotes transformation partly via chemokine CCL20 induction

Tsai, Sen Tien; Chien, I-Hsiu; Shen, Wenhao; Kuo, Yi-Zih; Jin, Ying‐Tai; Wong, Tai‐Chee; Hsiao, Jenn-Ren; Wang, Hsing-Ping; Shih, Neng‐Yao; Wu, Li-Wha

doi:10.1016/j.ejca.2010.03.018

Cited by 98 publications

(92 citation statements)

References 31 publications

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“…Enolase 1 showed overexpression in head and neck cancer, and high-ENO1 patients had significantly poor clinical outcomes. 17 Increased ENO1 mRNA expression was also preferentially detected in estrogen receptorYpositive breast cancer tissues, and decreasing ENO1 expression significantly augmented cytotoxicity in tamoxifen-resistant breast cancer cells. 18 Aldolase is a tetrameric glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyc-eraldehyde 3-phosphate and dihydroxyacetone phosphate.…”

Section: Discussionmentioning

confidence: 98%

Identification of Cervical Cancer Proteins Associated With Treatment With Paclitaxel and Cisplatin in Patients

Liu

Han

Ruoran

et al. 2011

International Journal of Gynecological Cancer

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Section: Discussionmentioning

confidence: 98%

Identification of Cervical Cancer Proteins Associated With Treatment With Paclitaxel and Cisplatin in Patients

Liu

Han

Ruoran

et al. 2011

International Journal of Gynecological Cancer

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“…Moreover, exogenous expression of a gene coding for a-enolase was found to promote cell proliferation, migration, invasion, and tumorogenesis [93].…”

Section: Enolase (Eno)mentioning

confidence: 99%

Enzymes of the central carbon metabolism: Are they linkers between transcription, DNA replication, and carcinogenesis?

et al. 2015

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“…1,3–5 Remarkably, accumulating evidence suggests that ENO1 can function as an oncogenic protein by promoting cell proliferation, invasion and metastasis. ENO1 expression is frequently increased in diverse tumors, including head and neck, 6 thyroid, 7 breast, 8 lung, 9,10 prostate, 11 colon and gastric cancer, 12,13 glioma 14 and cholangiocarcinoma. 15 Moreover, overexpression of ENO1 is positively associated with progression and poor prognosis in several tumors.…”

mentioning

confidence: 99%

FBXW7 negatively regulates ENO1 expression and function in colorectal cancer

Zhan

Wang

Zhao

et al. 2015

Laboratory Investigation

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FBXW7 (F-box and WD40 domain protein 7) is a tumor suppressor frequently inactivated in human cancers. The precise molecular mechanisms by which FBXW7 exerts antitumor activity remain under intensive investigation and are thought to relate in part to FBXW7-mediated destruction of key cancer-relevant proteins. Enolase 1 (ENO1) possesses oncogenic activity and is often overexpressed in various human cancers, besides its critical role in glycolysis. However, the detailed regulatory mechanisms of ENO1 expression remain unclear. Here we show that the elevated expression of ENO1 was identified in FBXW7-depletion HCT116 cells through two-dimensional protein electrophoresis and mass spectrometry assays (2DE-MS). Subsequent western blotting and immunohistochemical assays confirmed that ENO1 expression reversely correlates with FBXW7 expression in several cells and colon cancer tissues. Furthermore, we show that FBXW7 physically binds to ENO1 and targets ENO1 for ubiquitin-mediated degradation. Functionally, we found that FBXW7 suppresses the ENO1-induced gene expression, lactate production, cell proliferation and migration. These findings suggest that ENO1 is a novel substrate of FBXW7, and its activity can be negatively regulated by FBXW7 at the posttranslational level. Our work provides a novel molecular insight into FBXW7-directed tumor suppression through regulation of ENO1.

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ENO1, a potential prognostic head and neck cancer marker, promotes transformation partly via chemokine CCL20 induction

Cited by 98 publications

References 31 publications

Identification of Cervical Cancer Proteins Associated With Treatment With Paclitaxel and Cisplatin in Patients

Identification of Cervical Cancer Proteins Associated With Treatment With Paclitaxel and Cisplatin in Patients

Enzymes of the central carbon metabolism: Are they linkers between transcription, DNA replication, and carcinogenesis?

FBXW7 negatively regulates ENO1 expression and function in colorectal cancer

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