Enlargement of the Liver in Diabetic Children

Observations on the structure and function of liver in indian diabetics

“…It was seen in 15 out of 63 patients compared with about 60 per cent in the series of Goodman (1953). However, contrary to the observations of Marble et al (1938), massive hepatomegaly was never encountered in the present study. The cause of hepatic enlargement has been differently explained.…”

“…Hepatic involvement in diabetes mellitus is well recognized. Marble et al (1938) and Grey et al (1945). believed that hepatic abnormalities encountered in these patients were secondary to poor control.…”

Clinical, Biochemical, and Histopathology Features of Patients With Glycogenic Hepatopathy

“…GH, or Mauriac syndrome, was described by Pierre Mauriac in patients with T1D as hepatomegaly and elevated liver function tests caused by glycogen accumulation in hepatocytes. 2,5 The term "glycogenic hepatopathy" was recently coined by Torbenson et al 4 to describe this condition. Hepatic glycogenosis occurs secondary to a combination of 2 main factors: elevated glucose levels and elevated insulin levels.…”

Re-emergence of a rare syndrome: A case of mauriac syndrome

“…In the late 1930s Joslin clinic reported a case series of 60 youngsters with hepatomegaly, growth failure, delayed sexual maturation, and severe uncontrollable diabetes. [ 4 ] Equal incidence is reported in males and females, with most of the cases occurring during adolescence. [ 5 ] With better control of sugar, the incidence of this syndrome has reduced rapidly and in the current era this is a very rare syndrome.…”