Enlargement of the Heart

Parkinson, John

doi:10.1016/s0140-6736(00)95874-4

Cited by 39 publications

(3 citation statements)

References 48 publications

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“…This accounts for the fact that the so-called " uncoiling " of the aorta (elongation and dilatation of this vessel) in the absence of hypertension is, as a rule, associated with hearts of normal size in elderly people (9,10 Anatomical studies of the elastic arteries in the senile period show that the aorta increases in length as well as in diameter. There is a marked lack of uniformity in length and diameter in the aortas of the senile period.…”

Section: Fig 2 Mean Volume-elasticity Curves Of Thoracic Aortas At mentioning

confidence: 99%

Studies on the Elastic Properties of Human Isolated Aorta

Hallock¹,

Benson²

1937

J. Clin. Invest.

296

100

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Section: Fig 2 Mean Volume-elasticity Curves Of Thoracic Aortas At mentioning

confidence: 99%

Studies on the Elastic Properties of Human Isolated Aorta

Hallock¹,

Benson²

1937

J. Clin. Invest.

296

100

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“…In order to obtain data in this direction we submitted the patients with congenital heart disease to radiocardiological and electrocardiographic examination of the heart, the purpose being not only to determine the type of enlargement for diagnostic purposes, but also to determine the degree of enlargement from a viewpoint of cardiac efficiency. The degree of enlargement is a fair index of the severity of the myocardial lesion and of the liability to failure (11,12,13). When Table VI is examined all the post-exercise values are abnormally high except in Case 16.…”

Section: Resultsmentioning

confidence: 99%

Lactic Acid Production During Rest and After Exercise in Subjects With Various Types of Heart Disease With Special Reference to Congenital Heart Disease 1

Hallock¹

1939

J. Clin. Invest.

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“…Bramwell and Duguid (1928) stated that "a surprising feature in many of these cases is the comparative well-being of the patients for several years after extensive cardiac damage must have already been established." Parkinson (1936), describing this lesion, said "it possesses clinical features of great interest such as the moderate symptoms which may accompany a heart so hugely dilated." Daley and Franks (1949) found "the ability of these patients to carry out a full day's work was remarkable."…”

Section: Discussionmentioning

confidence: 99%

The Right Ventricle and Small Pulmonary Arteries in Aneurysmal Dilatation of the Left Atrium

Best¹,

Heath²

1964

Heart

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The original and subsequent early reports of aneurysmal dilatation of the left atrium (Owen and Fenton, 1901; Jones, 1901;Owen, 1902;Lutembacher, 1917Lutembacher, , 1918 Emanuel, 1923; Shaw, 1924;Schott, 1924; East, 1926; Cowan, 1926) were collected together and analysed by Bramwell and Duguid (1928). They concluded that two main factors were concerned in the aetiology of this condition. A "passive factor" was gross fibrosis of the wall of the left atrium: this was usually, but not always, due to chronic rheumatic heart disease that had predominantly affected this chamber. An "active factor" was increased flow of blood into the inelastic fibrous left atrium commonly from a hypertrophied left ventricle through an incompetent mitral valve. They stated that " one cannot fail to be impressed by the fact that the condition is so constantly associated with great ventricular hypertrophy," and this applied in their collected series of cases not only to the left ventricular hypertrophy associated with mitral incompetence but also to right ventricular hypertrophy. Of the 20 cases in their series the state of the right ventricle at necropsy was specified in 13, and in 10 of these it was said to be hypertrophied. Wood (1954) also stated that "mitral incompetence is a more important cause of left atrial dilatation than mitral stenosis ". In the face of these data and opinions we thought it would be of interest to see how many of our cases coming to necropsy, with extreme dilatation of the left atrium, had mitral incompetence, right ventricular hypertrophy, and pulmonary vascular disease. SUBJECTS AND METHOD Necropsy material was available from nine patients with extreme dilatation of the left atrium who had died of chronic rheumatic heart disease. Five were men (Table).At necropsy the thickness of the right ventricle and the size of the mitral valve orifice had been measured. Paraffin-embedded blocks of lung were available. Thin sections of lung were stained to demonstrate elastic tissue by the Lawson modification of the Weigert-Sheridan method and counterstained for collagen and muscle with van Gieson's reagents. Measurements were made of the external diameter of the media and average thickness of the media of pulmonary arteries up to 300t in diameter, which had been sectioned as nearly as possible transversely. Only vessels that were virtually circular in transverse section were measured; this method of selection decreased the number of arteries included in each study but avoided error in the measurement of the vessel diameter. Approximately 15 to 40 small muscular pulmonary arteries were measured in each case. The external diameter was taken as the mean of two measurements, at right angles to each other, of the distance between diametrically opposite points on the external elastic lamina. The medial thickness was estimated as the mean of four measurements taken at points approximately equally spaced around the vessel wall. From these data the thickness of the media was expressed as a percentage of the external diameter ...

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Enlargement of the Heart

Cited by 39 publications

References 48 publications

Studies on the Elastic Properties of Human Isolated Aorta

Studies on the Elastic Properties of Human Isolated Aorta

Lactic Acid Production During Rest and After Exercise in Subjects With Various Types of Heart Disease With Special Reference to Congenital Heart Disease 1

The Right Ventricle and Small Pulmonary Arteries in Aneurysmal Dilatation of the Left Atrium

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