“…These medications include oral isotretinoin, antiandrogen hormonal treatments such as oral contraceptive pills, plant extracts used in cosmetic topical preparations, topical vitamin A derivatives, niacinamide, and even chemical peels [2,15]. Laser and EBD procedures have been continuously explored as potential treatments of enlarged facial pores [16][17][18][19][20][21][22][23][24][25]. Depending on their intrinsic mechanisms of action, several devices have been reported in the literature to target the different pathophysiologic factors that contribute to the appearance of these patulous skin openings [1,2,9,11].…”