Enlarged perivascular spaces in the centrum semiovale are associated with poststroke depression: A 3-month prospective study

Liang, Yan; Chan, Yuen-Lai; Deng, Min; Chen, Yang Kun; Mok, Vincent; Wang, De Feng; Ungvári, Gábor S.; Chu, Winnie C.W.; Tang, Wai Kwong

doi:10.1016/j.jad.2017.11.080

Cited by 25 publications

(21 citation statements)

References 39 publications

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“…Odds ratio (95% confidence interval, P-value) The prevalence of PSA and PSD in our study was lower compared to other reports on the Chinese population, which were 15.1 and 21.1% at 3 months after ischemic stroke (20,21). This inconsistency may be ascribed to the different test scales of anxiety and depressive symptoms, time frame, and study criteria.…”

Section: Sleep Duration (H)contrasting

confidence: 85%

Impact of Sleep Duration on Depression and Anxiety After Acute Ischemic Stroke

et al. 2021

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Background: Abnormal sleep duration predicts depression and anxiety. We seek to evaluate the impact of sleep duration before stroke on the occurrence of depression and anxiety at 3 months after acute ischemic stroke (AIS).Methods: Nationally representative samples from the Third China National Stroke Registry were used to examine cognition and sleep impairment after AIS (CNSR-III-ICONS). Based on baseline sleep duration before onset of stroke as measured by using the Pittsburgh Sleep Quality Index (PSQI), 1,446 patients were divided into four groups: >7, 6–7, 5–6, and <5 h of sleep. Patients were followed up with the General Anxiety Disorder-7 (GAD-7) and Patient Health Questionnaire-9 (PHQ-9) for 3 months. Poststroke anxiety (PSA) was defined as GAD-7 of ≥5 and poststroke depression (PSD) as PHQ-9 of ≥5. The association of sleep duration with PSA and PSD was evaluated using multivariable logistic regression.Results: The incidences of PSA and PSD were 11.2 and 17.6% at 3 months, respectively. Compared to a sleep duration of >7 h, 5–6 h, and <5 h of sleep were identified as risk factors of PSA [odds ratio (OR), 1.95; 95% confidence interval (CI), 1.24–3.07; P < 0.01 and OR, 3.41; 95% CI, 1.94–6.04; P < 0.01) and PSD (OR, 1.47; 95% CI, 1.00–2.17; P = 0.04 and OR, 3.05; 95% CI, 1.85–5.02; P < 0.01), while 6–7 h of sleep was associated with neither PSA (OR, 1.09; 95% CI, 0.71–1.67; P = 0.68) nor PSD (OR, 0.92; 95% CI, 0.64–1.30; P = 0.64). In interaction analysis, the impact of sleep duration on PSA and PSD was not affected by gender (P = 0.68 and P = 0.29, respectively).Conclusions: Sleep duration of shorter than 6 h was predictive of anxiety and depression after ischemic stroke.

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Section: Sleep Duration (H)contrasting

confidence: 85%

Impact of Sleep Duration on Depression and Anxiety After Acute Ischemic Stroke

et al. 2021

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“…Recently, some studies in aging adults demonstrated that EPVS were associated with an increased risk of incident stroke, dementia, and depression (8)(9)(10). Moreover, growing evidence indicates that EPVS are more prevalent in stroke patients (11,12), and a high EPVS burden can predict poor outcomes after stroke (11,13,14). However, few studies have explored the relationship of EPVS to hemorrhagic transformation (HT) following ischemic stroke.…”

Section: Introductionmentioning

confidence: 99%

Enlarged perivascular spaces and hemorrhagic transformation after acute ischemic stroke

Song¹,

Cheng²,

Wang³

et al. 2021

Ann Transl Med

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Background: Enlarged perivascular spaces (EPVS) are considered to be neuroimaging markers of cerebral small vessel disease (CSVD). It remains unknown whether EPVS are associated with hemorrhagic transformation (HT) after acute ischemic stroke (AIS). We performed this retrospective cohort study to explore the associations of EPVS with clinical risk factors and other CSVD imaging features, and to investigate the relationship between EPVS and HT in patients with AIS.Methods: AIS patients admitted within 24 hours of stroke onset between January 2016 and December 2017 were consecutively enrolled. EPVS, lacunes, and white matter hyperintensities (WMH) were rated with validated rating scales on magnetic resonance images after the stroke. HT was defined as hemorrhage determined by follow-up brain imaging during the patients' hospital stay. Logistic regression was used to determine the risk factors and associations with other CSVD markers of EPVS in the basal ganglia (BG) and centrum semiovale (CS) regions, and the impact of EPVS on HT was further explored.Results: Among 494 included patients (mean age 66.4 years, 58.1% male), 81 (16.4%) experienced HT. In the multivariate logistic analyses, increasing age [odd ratio (OR) 1.041, 95% confidence interval (CI), 1.017-

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“…In some studies, the influence of different types of cerebral vasculopathy for PSD in ischemic stroke patients was assessed. Enlarged perivascular spaces (markers of cerebral small vessel disease) in the centrum semiovale on axial T2 weighted MRI independently predicted PSD occurrence at a 3-month period after stroke, according to the Liang et al data ( 53 ). Severe white matter hyperintensities, another cerebral sign that reflects cerebral microvasculopathy, were identified as an independent factor of PSD at 3 months after stroke onset ( 54 ).…”

Section: Neuroimaging Biomarkers Of Psdmentioning

confidence: 99%

Poststroke Depression Biomarkers: A Narrative Review

Levada

2018

Front. Neurol.

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Poststroke depression (PSD) is the most prevalent psychiatric disorder after stroke, which is independently correlated with negative clinical outcome. The identification of specific biomarkers could help to increase the sensitivity of PSD diagnosis and elucidate its pathophysiological mechanisms. The aim of current study was to review and summarize literature exploring potential biomarkers for PSD diagnosis. The PubMed database was searched for papers published in English from October 1977 to December 2017, 90 of which met inclusion criteria for clinical studies related to PSD biomarkers. PSD biomarkers were subdivided into neuroimaging, molecular, and neurophysiological. Some of them could be recommended to support PSD diagnosing. According to the data, lesions affecting the frontal-subcortical circles of mood regulation (prefrontal cortex, basal nuclei, and thalamus) predominantly in the left hemisphere can be considered as neuroimaging markers and predictors for PSD for at least 1 year after stroke. Additional pontine and lobar cerebral microbleeds in acute stroke patients, as well as severe microvascular lesions of the brain, increase the likelihood of PSD. The following molecular candidates can help to differentiate PSD patients from non-depressed stroke subjects: decreased serum BDNF concentrations; increased early markers of inflammation (high-sensitivity C-reactive protein, ferritin, neopterin, and glutamate), serum pro-inflammatory cytokines (TNF-α, IL-1β, IL-6, IL-18, IFN-γ), as well as pro-inflammatory/anti-inflammatory ratios (TNF-α/IL-10, IL-1β/IL-10, IL-6/IL-10, IL-18/IL-10, IFN-γ/IL-10); lowered complement expression; decreased serum vitamin D levels; hypercortisolemia and blunted cortisol awakening response; S/S 5-HTTLPR, STin2 9/12, and 12/12 genotypes of the serotonin transporter gene SLC6A4, 5-HTR2a 1438 A/A, and BDNF met/met genotypes; higher SLC6A4 promoter and BDNF promoter methylation status. Neurophysiological markers of PSD, that reflect a violation of perception and cognitive processing, are the elongation of the latency of N200, P300, and N400, as well as the decrease in the P300 and N400 amplitude of the event-related potentials. The selected panel of biomarkers may be useful for paraclinical underpinning of PSD diagnosis, clarifying various aspects of its multifactorial pathogenesis, optimizing therapeutic interventions, and assessing treatment effectiveness.

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Enlarged perivascular spaces in the centrum semiovale are associated with poststroke depression: A 3-month prospective study

Cited by 25 publications

References 39 publications

Impact of Sleep Duration on Depression and Anxiety After Acute Ischemic Stroke

Impact of Sleep Duration on Depression and Anxiety After Acute Ischemic Stroke

Enlarged perivascular spaces and hemorrhagic transformation after acute ischemic stroke

Poststroke Depression Biomarkers: A Narrative Review

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