Enkephalinergic Circuit Involved in Nociceptive Modulation in the Spinal Dorsal Horn

Bai, Yang; Li, Mengying; Ma, Jia; Li, Jiani; Teng, Xiao‐Yu; Chen, Ying-Biao; Yin, Jun-Bin; Huang, Jing; Chen, Jing; Zhang, Ting; Qiu, Xin-Tong; Chen, Tao; Li, Hui; Wu, Shengxi; Peng, Yanan; Li, Xiang; Kou, Zhenzhen; Li, Yunqing

doi:10.1016/j.neuroscience.2019.12.020

Cited by 2 publications

(1 citation statement)

References 64 publications

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“…After intraperitoneally injecting Ketamine/Xylazine mixture in 100 and 10 mg/kg body weight, respectively, the mice were deeply anesthetized and fixed in the prone position on a stereotaxic apparatus (NARISHIGE Scientific Instrument Las, Tokyo, Japan). The microinjector (1 µl, Hamilton, NV, United States) was introduced into the PBN according to the following coordinates: 5.1 mm after the anterior fontanelle, 1.25 mm outside the midline, and 3.4 mm below the surface of the skull (Bai et al, 2020). A small hole was drilled into the skull above the PBN position, the broken bone was removed, and a hemostatic sponge was used to remove the oozing blood.…”

Section: Brain Stereotaxic Injectionmentioning

confidence: 99%

Proanthocyanidins Inhibit the Transmission of Spinal Pain Information Through a Presynaptic Mechanism in a Mouse Inflammatory Pain Model

Fan

Zhu

et al. 2022

Front. Neurosci.

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Inflammatory pain is one of the most common symptoms of clinical pain that seriously affects patient quality of life, but it currently has limited therapeutic options. Proanthocyanidins, a group of polyphenols enriched in plants and foods, have been reported to exert anti-inflammatory pain-alleviating effects. However, the mechanism by which proanthocyanidins relieve inflammatory pain in the central nervous system is unclear. In the present study, we observed that intrathecal injection of proanthocyanidins inhibited mechanical and thermal pain sensitivity in mice with inflammatory pain induced by Complete Freund’s Adjuvant (CFA) injection. Electrophysiological results further showed that proanthocyanidins inhibited the frequency of spontaneous excitatory postsynaptic currents without affecting the spontaneous inhibitory postsynaptic currents or the intrinsic properties of parabrachial nucleus-projecting neurons in the spinal cord. The effect of proanthocyanidins may be mediated by their inhibition of phosphorylated activation of the PI3K/Akt/mTOR pathway molecules in dorsal root ganglia neurons. In summary, intrathecal injection of procyanidin induces an obvious anti-inflammatory pain effect in mice by inhibiting peripheral excitatory inputs to spinal neurons that send nociceptive information to supraspinal areas.

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Section: Brain Stereotaxic Injectionmentioning

confidence: 99%

Proanthocyanidins Inhibit the Transmission of Spinal Pain Information Through a Presynaptic Mechanism in a Mouse Inflammatory Pain Model

Fan

Zhu

et al. 2022

Front. Neurosci.

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Enkephalins and Pain Modulation: Mechanisms of Action and Therapeutic Perspectives

García-Domínguez

2024

Biomolecules

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Enkephalins, a subclass of endogenous opioid peptides, play a pivotal role in pain modulation. Enkephalins primarily exert their effects through opioid receptors located widely throughout both the central and peripheral nervous systems. This review will explore the mechanisms by which enkephalins produce analgesia, emotional regulation, neuroprotection, and other physiological effects. Furthermore, this review will analyze the involvement of enkephalins in the modulation of different pathologies characterized by severe pain. Understanding the complex role of enkephalins in pain processing provides valuable insight into potential therapeutic strategies for managing pain disorders.

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Enkephalinergic Circuit Involved in Nociceptive Modulation in the Spinal Dorsal Horn

Cited by 2 publications

References 64 publications

Proanthocyanidins Inhibit the Transmission of Spinal Pain Information Through a Presynaptic Mechanism in a Mouse Inflammatory Pain Model

Proanthocyanidins Inhibit the Transmission of Spinal Pain Information Through a Presynaptic Mechanism in a Mouse Inflammatory Pain Model

Enkephalins and Pain Modulation: Mechanisms of Action and Therapeutic Perspectives

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