Enkephalin-containing nerve cell bodies in the substantia nigra of the rat: Demonstration by immunohistochemistry and in situ hybridization

Vankova, Myriana; Arluison, Michel; Boyer, Pierre-Alain; Bourgoin, S.; Quignon, Monique

doi:10.1016/0361-9230(91)90275-o

Cited by 12 publications

(1 citation statement)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This interpretation is supported by the fact that nigral Menk is not present in the DA‐sensitive striatal–nigral pathway, but is associated with an unknown nigral afferent projection apparently not DA‐dependent. This projection could be the amygdalo–nigral pathway that has been reported to utilize met‐enkephalin, dynorphin and neurotensin as neurotransmitters or co‐transmitters (Vankova et al . 1991, 1992).…”

Section: Discussionmentioning

confidence: 99%

Contrasting responses by basal ganglia met‐enkephalin systems to low and high doses of methamphetamine in a rat model

Alburges¹,

Keefe²,

Hanson³

2001

Journal of Neurochemistry

View full text Add to dashboard Cite

The influence of methamphetamine (METH) on basal ganglia met-enkephalin (Menk) was studied by determining levels of this peptide in striatal, pallidal and nigral regions after administering a single low (0.5 mg/kg) or high (10 mg/kg) dose of this stimulant. The Menk levels in the striatal and pallidal areas were reduced and increased after the low- and high-dose METH treatments, respectively, 12 h after drug administration in all striatal and pallidal regions examined. The low-dose effect appeared to be principally influenced by increased activation of the dopamine D2-like receptor, while the high-dose effect seemed to result from dominance of D1-like receptor activation. However, both effects required coactivation of D1- and D2-like receptors. For the most part, both low- and high-dose METH-induced changes in Menk tissue content were fully recovered by 24 h. The Menk levels were not significantly altered in the substantia nigra 3-24 h after either METH treatment. Results reported herein indicated that striatal and pallidal Menk pathways respond differently after acute treatment with low or high doses of METH.

show abstract

Section: Discussionmentioning

confidence: 99%