Enkelytin and opioid peptide association in invertebrates and vertebrates: immune activation and pain

Stefano, George B.; Fricchione, Gregory L.

doi:10.1016/s0167-5699(98)01268-7

Cited by 91 publications

(45 citation statements)

References 23 publications

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“…These reports also demonstrate, on a pharmacological and biochemical basis, that the corresponding receptors are present as well, along with the intracellular second messenger communication processes [23][24][25][26]. Opioid peptides and opiate alkaloids (e.g., enkephalins, morphine) are also present with their respective receptors and biosynthetic pathways [27][28][29][30][31]. From a neuroimmune perspective, the same chemical messengers and their receptors have been found on invertebrate immunocytes, including nitric oxide coupling, allowing neurons to communicate with the immune cells, including microglia [32][33][34][35][36][37][38][39][40][41][42] (Figures 1 and 2).…”

Section: Common Set Of Shared Signal Moleculesmentioning

confidence: 93%

Evolutionary Perspective on Microglial/Neuronal Coupling with Special Relevance to Psychiatric Illnesses

Stefano¹,

Kream²

2015

J Psychiatry

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Journal of Psychiatry AbstractMicroglia have selectively evolved as a morphologically and chemically distinct class of immuno-competent CNS resident cells with potent bidirectional signaling capabilities linked to induction of a macrophage-like phenotype following metabolic, microbiological, or viral insults. It has been empirically determined that a conserved set of shared chemical messengers connects a communication network mediating reciprocal exchange of regulatory information between immune, central nervous, and neuroendocrine systems. From an evolutionary perspective, the pluripotent neuro-protective capabilities of invertebrate microglia have been extended and amplified in classes of mammalian microglia. The state-dependent plasticity of microglia has provoked considerable empirical investigation into their functional/regulatory roles in mediating innate immune surveillance and neural protection within the CNS. Upon pathophysiological dysregulation, aberrant microglial activities may provide significant contributory factors in the etiology and persistence of major neurological, degenerative, and psychiatric disorders. Within this context, invertebrate microglia appear to represent highly appropriate model systems to investigate underlying cellular and molecular mechanisms involved in higher order neuroimmune regulation of multiple CNS activities by mammalian microglia.

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Section: Common Set Of Shared Signal Moleculesmentioning

confidence: 93%

Evolutionary Perspective on Microglial/Neuronal Coupling with Special Relevance to Psychiatric Illnesses

Stefano¹,

Kream²

2015

J Psychiatry

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“…The general physiological functioning of cephalopods is impressive: for example, their food conversion efficiency is significantly greater than that of mammals (Boyle 1987). They have an adrenal system and release adrenal hormones in response to situations that would elicit pain and distress in humans (Broom 1998, Stefano et al 1998. They secrete noradrenaline and dopamine in response to disturbing events (e.g.…”

Section: Capabilities Of Aquatic Animals and The Need For Protectionmentioning

confidence: 99%

Cognitive ability and sentience: Which aquatic animals should be protected?

Broom¹

2007

Dis. Aquat. Org.

120

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It is of scientific and practical interest to consider the levels of cognitive ability in animals, which animals are sentient, which animals have feelings such as pain and which animals should be protected. A sentient being is one that has some ability to evaluate the actions of others in relation to itself and third parties, to remember some of its own actions and their consequences, to assess risk, to have some feelings and to have some degree of awareness. These abilities can be taken into account when evaluating welfare. There is evidence from some species of fish, cephalopods and decapod crustaceans of substantial perceptual ability, pain and adrenal systems, emotional responses, long-and short-term memory, complex cognition, individual differences, deception, tool use, and social learning. The case for protecting these animals would appear to be substantial. A range of causes of poor welfare in farmed aquatic animals is summarised.

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“…This suggests a new processing of these neuropeptide precursors in immunocytes or endothelial cells, not yet known. Recent data in human have shown that an injury to the endothelium might initiate and promote the atherosclerotic process and this 'response to injury' concept is now widely accepted [46]. Information obtained in the past few years concerning the various atheromatous cellular components in spontaneous atherogenesis pointed out, at earlier stage, an accumulation of monocyte-derived macrophages, foam cell formation and interactions among lipoproteins, lymphocytes and other immune mediators, the process ultimately involving an inflammatory state in which macrophages and T lymphocytes play a major role [47][48][49].…”

Section: Leeches : Antibacterial Peptides For Cardiovascular Diseasesmentioning

confidence: 99%

Neuropeptide-Derived Antimicrobial Peptides from Invertebrates for Biomedical Applications

Salzet

2005

CMC

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Abstract:Since the beginning of the 20th century, important medicinal progress has led medical doctors to think that the end of devastating epidemics has arrived. In 1930, the discovery of sulfamides and penicillin opened a wide area of applications able to fight against bacterial infections. However, almost all antibiotics were baffled by the great ability to adaptation of bacteria (1) and the emergence of new bacterial agents, discovered with up-dated technologies. The living world is perpetually in co-evolution and since more than 3 billion years, bacteria have developed resistance mechanisms to overcome external aggressions. Thus, in the middle of the 80th century, multi-resistant bacteria appeared and disseminated out from hospitals. In this context, researches have been developed in order to find new antimicrobial substances to destroy such new types of bacteria. Thus, several groups have turned their focus on invertebrates, which co-evoluad with human and have appeared on the planet since a long time. Evidence of new families of antimicrobial substances isolated from invertebrates different to the classical cationic peptide family i.e. dipeptides and anionic peptides been given. Moreover, these molecules are also present in human and may serve in the innate immune response as an important survival strategy.

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Enkelytin and opioid peptide association in invertebrates and vertebrates: immune activation and pain

Cited by 91 publications

References 23 publications

Evolutionary Perspective on Microglial/Neuronal Coupling with Special Relevance to Psychiatric Illnesses

Evolutionary Perspective on Microglial/Neuronal Coupling with Special Relevance to Psychiatric Illnesses

Cognitive ability and sentience: Which aquatic animals should be protected?

Neuropeptide-Derived Antimicrobial Peptides from Invertebrates for Biomedical Applications

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