Enigmatic Induction of Cytomixis in Allium Cepa Root Meristem by Aglaia Edulis Roxb. Leaf Extract and Its Phytochemical Rationale

Ravindran, Archana Elamkulam; Thoppil, John Ernest

doi:10.22159/ajpcr.2020.v13i3.36429

Cited by 2 publications

(2 citation statements)

References 14 publications

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“…Evaluation of cytotoxicity and apoptotic potential of Ophiorrhiza pectinata [27] also gives the best evidence of using the plant model for preliminary assessment of toxicity studies. Leaf extract of Aglaia edulis was proved to be a source of potential bioactive compounds which found has triggered aberrations in Allium root meristem among which cytomixis was found to be the prominent one [43]. The data obtained from the study of modulatory action of the extract of Cynanchum sarcomedium on oxidative stress induced by H 2 O 2 [35] further strengthens and in accordance with the findings of our study.…”

Section: Discussionsupporting

confidence: 89%

Genotoxicity Evaluation of Cissus Latifolia Lam. And Its Genoprotective Effect on Oxidative Damage Induced by Hydrogen Peroxide

Mattummal

Thoppil

2020

Asian J Pharm Clin Res

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Objective: This study focused on the genotoxic efficacy of higher concentrations of methanolic extract of Cissus latifolia Lam. and its genoprotective role at lower concentrations against the induced cytogenetic aberrations by 2% hydrogen peroxide [H2O2] on the Allium cepa plant model. Methods: Cytotoxic and genoprotective potential of the plant extract were analyzed using A. cepa assay. The treatment modes that were designed for antigenotoxicity screening were pre-treatment, post-treatment, and concurrent treatment. Results: Results revealed the toxic effect of extract of C. latifolia which induced major chromosomal abnormalities, namely, nuclear lesions, chromosome vagrants, stickiness, bridges, and chromosome breaks. These aberrations were found to be unaltered and showed the potent clastogenic nature of plant extract. As concentrations of plant extract and exposure time increase, the frequency of occurrence of cytogenetic aberrations was also detected to be more. Further, the potential genotoxicity of plant measured in terms of mitotic index reduction also confirms its significant role in inducing mutagenicity. The genoprotective efficacy of extract was identified as its ability to inhibit and reverse the aberrations caused by H2O2 at lower concentrations of plant extract. Conclusions: Dose-dependent data highlight the cytotoxic and genoprotective effect of C. latifolia on the A. cepa model. These findings will help to exploit the plant as an anticancer drug and explore other wide arrays of therapeutic activities of C. latifolia.

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Section: Discussionsupporting

confidence: 89%

Genotoxicity Evaluation of Cissus Latifolia Lam. And Its Genoprotective Effect on Oxidative Damage Induced by Hydrogen Peroxide

Mattummal

Thoppil

2020

Asian J Pharm Clin Res

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“…Plant-derived compounds are being used in anticancer studies [24]. Plant extract is the main source of potential bioactive compounds that might have generated the aberrations in Allium root tip meristem [25]. Apoptosis is an important developmental and regulated process which may occur due to the cytogenetic changes in the cell [26].…”

Section: Dpph Free Radical Scavenging Assaymentioning

confidence: 99%

Assessment of Antioxidant Potential and Antigenotoxicity Analysis Through Hydrogen Peroxide-Induced Oxidative Stress in Terminalia Paniculata Roth

Aswathi¹,

Thoppil²

2020

Asian J Pharm Clin Res

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Objective: The present study is mainly focused on the antigenotoxicity and antioxidant potential of the fruit extract of an important dye yielding plant Terminalia paniculata Roth. Methods: Genoprotective activity of the fruit extract was studied by Allium cepa root tip assay. Three modes of treatment were used to perform the antigenotoxicity, that is, pre-treatment, post-treatment, and simultaneous treatment. For the study of antioxidant potential, four different assays were performed. Results: Antigenotoxicity studies revealed the protective role of the extract in chromosomal aberrations induced by 2% hydrogen peroxide (H2O2) on A. cepa root tip meristem. The fruit extract showed a significant modulatory effect by means of an inhibition percentage and also it showed a characteristic reversing of chromosomal aberrations induced by H2O2. While in the case of antioxidant activity, the plant extract showed an appreciable antioxidant potential. Four different assays were used to determine the antioxidant potential of T. paniculata. Of these 2,2-diphenyl-1-picryl-hydrazyl-hydrate radical scavenging activity revealed almost equal effect to that of the standard. Conclusions: In the present investigation, it has been found that the important dye yielding plant T. paniculata has a significant role in various commercial industries such as food, cosmetics, clothes, and pharmaceutics due to its efficient protective role.

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Enigmatic Induction of Cytomixis in Allium Cepa Root Meristem by Aglaia Edulis Roxb. Leaf Extract and Its Phytochemical Rationale

Cited by 2 publications

References 14 publications

Genotoxicity Evaluation of Cissus Latifolia Lam. And Its Genoprotective Effect on Oxidative Damage Induced by Hydrogen Peroxide

Genotoxicity Evaluation of Cissus Latifolia Lam. And Its Genoprotective Effect on Oxidative Damage Induced by Hydrogen Peroxide

Assessment of Antioxidant Potential and Antigenotoxicity Analysis Through Hydrogen Peroxide-Induced Oxidative Stress in Terminalia Paniculata Roth

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