Enhancing wound healing and adhesion through dopamine-assisted gelatin-silica hybrid dressings

Lin, Yu-Chien; Wang, Huey-Yuan; Tang, Yao-Chun; Lin, Wan-Rong; Tseng, Ching-Li; Hu, Chih-Chien; Chung, Ren-Jei

doi:10.1016/j.ijbiomac.2023.128845

International Journal of Biological Macromolecules

2024

DOI: 10.1016/j.ijbiomac.2023.128845

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Enhancing wound healing and adhesion through dopamine-assisted gelatin-silica hybrid dressings

Yu-Chien Lin,

Huey-Yuan Wang,

Yao-Chun Tang

et al.

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2024

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Sustained Antibiotic Release from Biodegradable Gelatin–Silica Hybrid for Orthopedic Infections

Lin,

Lee,

Jones

et al. 2024

Adv Funct Materials

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Antibiotic‐loaded polymethylmethacrylate (PMMA) beads are commonly employed to treat prosthetic joint infections (PJI) and chronic osteomyelitis due to their excellent mechanical strength. However, PMMA's non‐degradability results in a burst release of antibiotics and potential renal toxicity, necessitating additional surgeries for bead removal. There is a critical need for infection control materials that can deliver antibiotics effectively, maintain adequate mechanical strength, and degrade uniformly. This study introduces a gelatin–silica hybrid antibiotic carrier, characterized by covalent bonds between the gelatin and silica networks. The incorporation of the silica network enhances the compressive strength to 32.53 ± 2.4 MPa and ensures uniform degradation over 6 months, aligning with clinical timelines. Furthermore, the gelatin–silica hybrid can support up to 10 wt% antibiotic loading without compromising its properties, making it a promising candidate for next‐generation infection control materials.

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Sustained Antibiotic Release from Biodegradable Gelatin–Silica Hybrid for Orthopedic Infections

Lin,

Lee,

Jones

et al. 2024

Adv Funct Materials

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Enhancing wound healing and adhesion through dopamine-assisted gelatin-silica hybrid dressings

Cited by 1 publication

References 52 publications

Sustained Antibiotic Release from Biodegradable Gelatin–Silica Hybrid for Orthopedic Infections

Sustained Antibiotic Release from Biodegradable Gelatin–Silica Hybrid for Orthopedic Infections

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