The purpose of this study is to determine the impact of social and political capital on the sustainability of MSMEs in the Era of Economic and Digital Disruption. The technique in this exploration utilizes a blended strategy research approach, in particular a mix of subjective and quantitative. It is hoped that the existing hypotheses can work in conjunction with one another by employing a combined approach. Qualitative methods always employ scientific logic, whereas quantitative methods always place an emphasis on process analysis of inductive thinking processes related to the dynamics of relationships between observed phenomena. The stages are: (1). Observing social phenomena, identifying, revising, and re-checking existing data; (2). Categorize the information obtained; (3). Tracing and explaining categorization; (4). Explain the categorization relationship; (5). Draw general conclusions; (6). Building or explaining a theory. The population in this study was all cooperatives, MSME centers, MSME clusters, and MSME groups that had digitized in facing the era of economic and digital disruption. The population is 380 MSMEs. Using the Slovin formula, then, a total of 192 MSMEs were sampled with various business backgrounds. The results of this study are: (1) that MSMEs use social capital in facing the era of economic and digital disruption with cooperatives as an intervening variable that have a significant positive effect; (2) that MSMEs use social capital in facing the era of economic and digital disruption with MSME centers as an intervening variable has a significant positive effect; (3) that MSMEs use social capital in facing the era of economic and digital disruption with the MSME Cluster as an intervening variable have no significant positive effect; (4) that MSME uses social capital in facing the era of economic and digital disruption with the MSME group as a variable intervening No significant positive effect; (5) that MSMEs use political capital in facing the era of economic and digital disruption with cooperatives as an intervening variable No significant positive effect; (6) that MSMEs use political capital in facing the era of economic and digital disruption with MSME centers as the intervening variable has a significant positive effect; (7) that MSMEs use political capital in facing the era of economic and digital disruption with the MSME cluster as an intervening variable have no significant positive effect; (8) that MSMEs use political capital in facing the era of economic and digital disruption with MSMEs groups as an intervening variable have a significant positive effect. This study concludes that social and political capital has an important role in the sustainability of MSMEs in the Era of Economic and Digital Disruption, especially in cooperatives, MSME centers, MSME clusters, and MSME groups.