Enhancing Therapeutic Approaches in Glioblastoma with Prooxidant Treatments and Synergistic Combinations: <em>In Vitro</em> Experience of Doxorubicin and Photodynamic Therapy
Bruno Agustín Cesca,
Matías Daniel Caverzan,
María Julia Lamberti
et al.
Abstract:Glioblastoma (GBM) is an aggressive brain cancer characterized by significant molecular and cellular heterogeneity, complicating treatment efforts. Current standard therapies, including surgical resection, radiation, and temozolomide (TMZ) chemotherapy, often fail to achieve long-term remission due to tumor recurrence and resistance. A pro-oxidant environment is in-volved in glioma progression, with oxidative stress contributing to the genetic instability that leads to gliomagenesis. However, the generation of… Show more
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