Enhancing the value of psychiatric mouse models; differential expression of developmental behavioral and cognitive profiles in four inbred strains of mice

d‐amino acid oxidase knockout (Dao−/−) mice show enhanced short‐term memory performance and heightened anxiety, but no sleep or circadian rhythm disruption

“…Moreover, there is phenotypic overlap between the models despite the use of different background strains (ddY, C57BL/6J and 129SvEv), each of which differs in terms of baseline anxiety and cognitive performance. 129 substrains, for example, are characterized by increased anxiety and impaired memory performance relative to other inbred strains (Voikar et al ., ; Rodgers et al ., ; Brooks et al ., ; Koike et al ., ; Molenhuis et al ., ). Our use of the 129SvEv strain may explain the generally poor recognition memory performance of Dao +/+ mice in the present study, which did not exceed chance in either odour or spatial recognition trials.…”

The Behavioral Consequence of Phenylketonuria in Mice Depends on the Genetic Background

“…As mentioned in the introduction, some articles show an intact ability to master a short-term or long-term memory task by both strains (Cabib et al, 2003; Molenhuis et al, 2014). In contrast, memory deficits in short-term novel object memory in the B6 (Cabib et al, 2003), reversal learning in the BTBR (Molenhuis et al, 2014), and cued and contextual fear conditioning in BTBR (MacPherson et al, 2008; Stapley et al, 2013) have been reported. The deficits found in BTBR could be restored with an increase in training (Stapley et al, 2013) and cage enrichment (MacPherson et al, 2008).…”

“…However, mixed results are described for the differences between the strains in anxiety-related behavior and learning and memory. For anxiety-related behavior, no differences (Cabib et al, 2003), a reduction (Molenhuis et al, 2014), and an increase of anxiety-related behavior of BTBR WT (Moy et al, 2007) compared to B6 WT are reported. Similar contradicting results are described for learning and memory.…”

“…For example, novelty induced activity is greater in BTBR WT than B6 WT (Cabib et al, 2003; Moy et al, 2007; Molenhuis et al, 2014) but decreased in home-cage conditions (Molenhuis et al, 2014). Furthermore, motor performance of the BTBR WT is inferior to the B6 WT on the rotarod (Nadler et al, 2006; Moy et al, 2007).…”

Chronic dietary changes in n-6/n-3 polyunsaturated fatty acid ratios cause developmental delay and reduce social interest in mice

“…Here we study the contributions of two different dietary n-6/n-3 PUFA ratios, namely by increasing and by decreasing this dietary ratio across all developmental stages, to determine how these PUFA ratios can influence development, cognitive functioning and behavioral expression. For these studies, we investigated the developmental impact of PUFA dietary composition in the BTBR mouse inbred strain, a commonly used ASD mouse model displaying the phenotypic features of disturbed social interaction and restrictive and repetitive behavior ( McFarlane et al, 2008;Meyza and Blanchard, 2017;Molenhuis et al, 2014;Pearson et al, 2011 ). In parallel, identical dietary changes in n-6/n-3 PUFA ratios were studied in the C57BL/6J mouse inbred strain, a commonly chosen reference strain (e.g., Molenhuis et al, 2014;Moy et al, 2004 ).…”