Enhancing the Sunscreen Efficacy of Bemotrizinol Micropigment by Using O/W Nanoemulsion Topical Preparations

Hashim, Dina Medhat; Sheta, Nermin M.; Elwazzan, Vivian S.; Sakran, Wedad

doi:10.22159/ijpps.2019v11i7.32652

Cited by 5 publications

(3 citation statements)

References 41 publications

(52 reference statements)

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“…The in vitro test related to the effect was continued with the SPF test, which correlated with quercetin's photoprotective properties against UV rays. [32].…”

Section: Discussionmentioning

confidence: 99%

Development Validation of Quercetin Compounds Using Rp-HPLC and in Vitro Activity Studies on Melastoma Malabathricum Leaf Nanocream Foundation Preparations

APRIDAMAYANTI,

SARI,

PRATIWI

2023

Int J App Pharm

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Objective: A simple, accurate, precise, sensitive, and robust analytical method has been developed to analyze quercetin in the nano-cream foundation formula added to the ethyl acetate fraction of Melastoma malabathricum leaves. Methods: The validation is consistent with ICH guidelines using a reversed-phase HPLC method with mobile-phase acetonitrile-phosphoric buffer conditions at pH 5.51 (40:60 v/v). The stationary phase has a C-18 column, a 0.5 ml/min flow rate, and an Ultraviolet detector at wavelength 370 nm. Furthermore, antioxidant activity testing used the FRAP method, and the SPF value was measured using a Elisa reader with wavelength 615nm and UV/Vis spectrophotometer in the wavelength range of 290-390 nm. Results: The results showed that the retention time of quercetin was 11.462 min with a tailing factor of 1.045. Regression equation y=170220x-85497 had a concentration range of 3-18 µg/ml and a correlation value of 0.9998. The limit of Detection (LOD) and Limit of Quantification (LOQ) were 0.236 and 0.786 µg/ml, respectively. The accuracy method for the recovery value at concentration levels of 80%, 100%, and 120% was 95.233%-109.446%. The repeatability of intra-day and inter-day variations express the %RSD values of 1.258-1.378% and 1.012-1.258%. Meanwhile, the method's strength by changing the column temperature, maximum wavelength, mobile phase composition, and the flow rate was expressed by the %RSD value of 0.045-0.067%, 0.069-1.642%, 0.107-0.165%, and 0.141-0.318%, respectively. The analysis results of the quercetin content in the nano cream foundation formula were 0.021728±5.83x10-4 mg/g. Antioxidant activity with an IC50 value was 1444.157±15.538 µg/ml, and the SPF at a concentration of 8000 µg/ml was 11.370±1.083. Conclusion: The development method of quercetin is simple, accurate, precise, sensitive, and robust. Quantitative analysis of quercetin biomarkers in nano cream preparations containing the ethyl acetate fraction of Melastoma malabathricum leaves using the RP-HPLC method.

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“…The in vitro test related to the effect was continued with the SPF test, which correlated with quercetin's photoprotective properties against UV rays. [32].…”

Section: Discussionmentioning

confidence: 99%

Development Validation of Quercetin Compounds Using Rp-HPLC and in Vitro Activity Studies on Melastoma Malabathricum Leaf Nanocream Foundation Preparations

APRIDAMAYANTI,

SARI,

PRATIWI

2023

Int J App Pharm

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“…For topical usage, this system has good stability and skin penetration capabilities, particularly for active ingredients derived from essential or plant oils (Mohite et al, 2019). Nanoemulsion system can reduce the globule size and increase the efficacy of oil in cosmetic preparations (Hashim et al, 2019). Preparations that are applied topically, such as sunscreen, must be absorbed quickly by the skin to provide a good therapeutic effect (Argenta et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Sunscreen effectivity and physical characterization of avocado oil in nanoemulsion using isopropyl myristate variations

Shabrina,

Firdausi,

Poerba

et al. 2024

Pharmaciana

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Unsaturated fatty acids in avocado oil can help reduce erythema brought on by prolonged UV-B exposure. The effectivity of sunscreen absorption into the skin will be enhanced by the use of isopropyl myristate (IPM) in nanoemulsion. The purpose of this study was to determine the physical characteristics and sunscreen effectiveness of avocado oil nanoemulsion (AVN) modified with IPM. 1% (FI), 3% (FII), and 5% (FIII) IPM variation were used to make AVN with 5% oil. The AVN were tested for physical characteristics such as organoleptic, pH, viscosity, rheology, particle size and polydispersity index (PI). The products were also tested for sunscreen effectivity by in vitro and Minimum Erythemal Dose (MED) method. The data obtained were analyzed statistically. The results showed that the AVN was pale yellow and clear with transmittance percentage were 96%. The rheogram showed that the products were newtonian. The pH values range were from 6.62 to 6.66; viscosity 1.65-1.84 dPa.s; particle size < 17 nm, zeta potential was in range of -30,54±1,72 to -37,85±3,11 and PI < 0.5 for all formula. In vitro SPF values were 16. 43 ± 4.50 (FI), 16.27 ± 4.20 (FII) and 17.88 ± 3.20 (FIII) (p >0.05), and categorized as ultra protection. MED value were 12.28 ± 1.34 (FI); 12.51 ± 1.68 (FII); and 13.22 ± 1.84 (FIII) (p< 0.05) and categorized as maximum protection. Isopropyl myristate increased the sunscreen product's MED value without changing its physical characteristics.

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“…Aloe-vera leaf extracts include a lot of polyphenol components and chemicals in them. Aloe vera's 75 potentially active elements include vitamin supplements, minerals, carbohydrates, enzymes, lignin, saponins, salicylic acids, and amino acids [10][11][12]. It has successfully treated sunburns, including both first and second-degree burns [13].…”

Section: Introductionmentioning

confidence: 99%

Formulation and Evaluation of Herbal Sunscreens: An Assessment Towards Skin Protection from Ultraviolet Radiation

Tiwari¹,

Indu²,

Gupta³

et al. 2022

Pharmacophore

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Sunscreen lotion is a sort of product that protects against the sun's harmful rays by containing ultraviolet radiation (UV rays), which is divided into two types: ultraviolet radiation A (UVA) and ultraviolet radiation B (UVB). The incorporation of herbal materials into sunscreen is one of the most effective and natural ways to protect against the sun, as measured by the sun protection factor (SPF), as well as the detrimental side effects of toxic chemicals. The present study aimed to develop herbal sunscreens containing turmeric (strong antiseptic property which protects skin from bacteria caused by excess sweat), coconut oil (used as a sun-block agent and helps to protect skin from sun damage), aloe vera (give a cooling effect to the skin and work as skin barrier), lemon (used to protect skin for sunburn) which will be effective for skin and protect skin against harmful sun rays, sunburn, and skin cancer. Prepared herbal sunscreens were evaluated for physicochemical characteristics, SPF, thermal stability, antioxidant activity, in vitro mutagenicity, and stability. Results showed that the F5 and F6 herbal sunscreens were of good consistency and viscosity with excellent antioxidant, non-mutagenic, nonirritant, stability activity and possessed 33.50 SPF for normal skin. In comparison to F1 through F4, formulations with a coconut oil base and carrot seed extract (F5 and F6) were shown to be stable and effective, with a high SPF.

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Enhancing the Sunscreen Efficacy of Bemotrizinol Micropigment by Using O/W Nanoemulsion Topical Preparations

Cited by 5 publications

References 41 publications

Development Validation of Quercetin Compounds Using Rp-HPLC and in Vitro Activity Studies on Melastoma Malabathricum Leaf Nanocream Foundation Preparations

Development Validation of Quercetin Compounds Using Rp-HPLC and in Vitro Activity Studies on Melastoma Malabathricum Leaf Nanocream Foundation Preparations

Sunscreen effectivity and physical characterization of avocado oil in nanoemulsion using isopropyl myristate variations

Formulation and Evaluation of Herbal Sunscreens: An Assessment Towards Skin Protection from Ultraviolet Radiation

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