Enhancing the sensitivity of point-of-use electrochemical microfluidic sensors by ion concentration polarisation – A case study on arsenic

Subramanian, V.; Lee, Sang-Jun; Jena, Sanjoy; Jana, Sourav Kanti; Ray, Debraj; Kim, Sung Jae; Pradeep, Thalappil

doi:10.1016/j.snb.2019.127340

Cited by 36 publications

(20 citation statements)

References 44 publications

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“…Likewise, a stir bar coated with AuNPs and combined with a microchip device has been shown to be effective in restoring DNA multi-arm link recovery for signal transduction and amplification purposes in the rapid detection of antibiotics [ 64 ]. In addition, some microfluidic pre-concentration/amplification techniques have been applied to biological samples such as isotachophoresis (ITP) [ 120 , 121 , 122 , 123 , 124 , 125 , 126 ], ion concentration polarization (ICP) [ 127 , 128 , 129 , 130 , 131 , 132 ], electrokinetic stacking (EKS) [ 133 , 134 , 135 , 136 , 137 ], field amplification stacking (FAS) [ 138 , 139 , 140 , 141 ], and multiplex electroanalytical techniques [ 142 , 143 ]. Although it has not been applied to milk analysis, it is also an important reference for future research.…”

Section: Discussionmentioning

confidence: 99%

Recent Advances in Microfluidic Devices for Contamination Detection and Quality Inspection of Milk

Lee

Kung

et al. 2021

Micromachines

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Milk is a necessity for human life. However, it is susceptible to contamination and adulteration. Microfluidic analysis devices have attracted significant attention for the high-throughput quality inspection and contaminant analysis of milk samples in recent years. This review describes the major proposals presented in the literature for the pretreatment, contaminant detection, and quality inspection of milk samples using microfluidic lab-on-a-chip and lab-on-paper platforms in the past five years. The review focuses on the sample separation, sample extraction, and sample preconcentration/amplification steps of the pretreatment process and the determination of aflatoxins, antibiotics, drugs, melamine, and foodborne pathogens in the detection process. Recent proposals for the general quality inspection of milk samples, including the viscosity and presence of adulteration, are also discussed. The review concludes with a brief perspective on the challenges facing the future development of microfluidic devices for the analysis of milk samples in the coming years.

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Section: Discussionmentioning

confidence: 99%

Recent Advances in Microfluidic Devices for Contamination Detection and Quality Inspection of Milk

Lee

Kung

et al. 2021

Micromachines

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“…In this paper, the recent progress of the ICP effect in the preconcentration of microsamples in a paper-based preconcentrator is reviewed, and the basic working principle, applications, and research progress of ICP are introduced. ICP preconcentration is also widely used in microfluidic chips on other substrates, such as PDMS [97,[119][120][121][122][123][124][125][126][127][128], polycarbonate [129], glass [127,[130][131][132][133][134][135], silicon [36,[136][137][138][139], and land hydrogels [140]. In addition, studies have been conducted on ICP preconcentration driven by ion-selective osmotic membrane pressure [141], ICP preconcentration of magnetic nanoparticles and magnets [142], etc.…”

Section: Discussionmentioning

confidence: 99%

Recent advances in paper‐based preconcentrators by utilizing ion concentration polarization

et al. 2021

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One of the most cited limitations of biochemical detection is its poor sensitivity, owing to the relatively high complexity of micro-samples. Moreover, some samples cannot be easily self-replicated and their abundance cannot be increased through traditional technologies. Therefore, the preconcentration of low-abundance samples is a key requirement for microfluidic biological analysis. In recent years, the ion-concentration polarization phenomenon has aroused widespread interest in the application of microfluidic technology. In addition, paper-based materials are readily available, easy to modify, and exhibit good hydrophilicity. The study of the ion-concentration polarization preconcentration of micro-samples in paper-based microfluidic chips is of considerable significance. In this review, we discuss the development and applications of ion-concentration polarization paper-based preconcentrator in the past 5 years, with emphasis on key progresses in chip fabrication and performance optimization under different conditions. The current needs and development prospects in this field have also been discussed.

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“…As (III) was detected down to 1 µg L −1 , while the voltammogram exhibited peaks specific to ions including Cu (II), Fe (II), Mn (II), and Pb (II). The authors proposed the use of their device, in combination with a portable electrochemical analyser, as a point of use sensor for resource limited areas [165].…”

Section: Electrochemical Detection For Microfluidicsmentioning

confidence: 99%

A Review of Microfluidic Detection Strategies for Heavy Metals in Water

Lace

Cleary

2021

Chemosensors

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Heavy metal pollution of water has become a global issue and is especially problematic in some developing countries. Heavy metals are toxic to living organisms, even at very low concentrations. Therefore, effective and reliable heavy metal detection in environmental water is very important. Current laboratory-based methods used for analysis of heavy metals in water require sophisticated instrumentation and highly trained technicians, making them unsuitable for routine heavy metal monitoring in the environment. Consequently, there is a growing demand for autonomous detection systems that could perform in situ or point-of-use measurements. Microfluidic detection systems, which are defined by their small size, have many characteristics that make them suitable for environmental analysis. Some of these advantages include portability, high sample throughput, reduced reagent consumption and waste generation, and reduced production cost. This review focusses on developments in the application of microfluidic detection systems to heavy metal detection in water. Microfluidic detection strategies based on optical techniques, electrochemical techniques, and quartz crystal microbalance are discussed.

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Enhancing the sensitivity of point-of-use electrochemical microfluidic sensors by ion concentration polarisation – A case study on arsenic

Cited by 36 publications

References 44 publications

Recent Advances in Microfluidic Devices for Contamination Detection and Quality Inspection of Milk

Recent Advances in Microfluidic Devices for Contamination Detection and Quality Inspection of Milk

Recent advances in paper‐based preconcentrators by utilizing ion concentration polarization

A Review of Microfluidic Detection Strategies for Heavy Metals in Water

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