Enhancing the magnetic relaxivity of MRI contrast agents via the localized superacid microenvironment of graphene quantum dots

Li, Yongqiang; Dong, Hui; Tao, Qianshan; Ye, Caichao; Yu, Mengmeng; Li, Jipeng; Zhou, Huifang; Yang, Siwei; Ding, Guqiao; Xie, Xiaoming

doi:10.1016/j.biomaterials.2020.120056

Cited by 50 publications

(41 citation statements)

References 67 publications

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“…The GPG was prepared in accordance with the previously proposed method by modifing GQDs with PEG and Gd 3+ via hydrothermal treatment. [ 21 ] As shown in Fig. 1 A, GPG has a uniform lateral size with an average diameter of 4.1 nm.…”

Section: Resultsmentioning

confidence: 99%

“…, oxhydryl, –OH; carboxyl, –COOH). [ 21 ] Given that there are many amino (–NH 2 ) groups on the surface of Ab, the abundant –COOH groups in the structure of GPG [ 36 ] could easily react with the –NH 2 groups easily via amidation. The Gd 4d spectrum of GPG is illustrated in Fig.…”

Section: Resultsmentioning

confidence: 99%

“…The GPG was prepared in accordance with the previously proposed method. [ 21 ] Briefly, the procedure can be divided into four steps. At first, 15 mg of GQDs and 0.05 mmol of PEG 6 were added into 15 mL of deionized water, and then transferred into para-polystyrene lined autoclave heating for 48 h at 240 ℃.…”

Section: Methodsmentioning

confidence: 99%

“…Recent studies show that introducing paramagnetic Gd 3+ -based probes could also provide high sensitivity [ 17 , 18 ]. For example, magnetic nanoparticles (MNPs) that consist of Gd 3+ and graphene quantum dots (GQDs) have numerous applications in developing MRI contrast agents in recent years with guaranteed biocompatibility and high relaxivity [ [19] , [20] , [21] ], which would be a promising probe for biomarker detection with high sensitivity. Meanwhile, ultra-low field (ULF) NMR (typical static field less than 250 μT) can realize a two-fold increase of relaxivity of Gd 3+ -based complexes compared to that measured at 1.5 T,[ 22 ] which could be beneficial for the biomarker detection.…”

Section: Introductionmentioning

confidence: 99%

“…Herein, we developed Gd 3+ -based MRSw consisting of Gd 3+ loaded polyethylene glycol (PEG) modified GQDs (GPG) [ 21 ] and specific antibody (Ab) against SARS-CoV-2 antigen S protein. The rapid and closed-tube detection of SARS-CoV-2 pseudovirus in a home-made ULF NMR system was realized with ultra-high sensitivity by measuring the change of longitudinal relaxation times.…”

Section: Introductionmentioning

confidence: 99%

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Computational Biomaterials: Computational Simulations for Biomedicine

Dai

Chen

2022

Advanced Materials

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Xinyue Dai received her Ph.D. degree at Shandong University. She is now a lecturer at Shanghai University. Her current research interests include the growth and etching simulations of lowdimensional nanomaterials, theoretical research of mechanical and electrical properties, and theoretical simulation of biomedical materials.Yu Chen received his Ph.D. degree at Shanghai Institute of Ceramics, Chinese Academy of Sciences (SICCAS). He is now the full professor in Shanghai University. His research focuses on materdicine, nanomedicine, nanobiotechnology, and computational biomaterials, which involve the design, fabrication, and biomedical applications of mesoporous nanoparticles, 2D nanosheets, and 3D-printing bioscaffolds. The focused biomedical applications include drug/gene delivery, molecular imaging, chemoreactive nanomedicine, energetic nanomedicine, theragenerative biomaterials and in situ localized disease therapy. He has published more than 260 scientific papers in the nanomedicine field with total citations of more than 28 000 (h-index: 91).

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Planted Graphene Quantum Dots for Targeted, Enhanced Tumor Imaging and Long‐Term Visualization of Local Pharmacokinetics

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et al. 2023

Advanced Materials

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While photoluminescent graphene quantum dots (GQDs) have long been considered very suitable for bioimaging owing to their protein‐like size, superhigh photostability and in vivo long‐term biosafety, their unique and crucial bioimaging applications in vivo remain unreachable. Herein, planted GQDs are presented as an excellent tool for in vivo fluorescent, sustainable and multimodality tumor bioimaging in various scenarios. The GQDs are in situ planted in the poly(ethylene glycol) (PEG) layer of PEGylated nanoparticles via a bottom‐up molecular approach to obtain the NPs‐GQDs‐PEG nanocomposite. The planted GQDs show more than four times prolonged blood circulation and 7–8 times increased tumor accumulation than typical GQDs in vivo. After accessible specificity modification, the multifunctional NPs‐GQDs‐PEG provides targeted, multimodal molecular imaging for various tumor models in vitro or in vivo. Moreover, the highly photostable GQDs enable long‐term, real‐time visualization of the local pharmacokinetics of NPs in vivo. Planting GQDs in PEGylated nanomedicine offers a new strategy for broad in vivo biomedical applications of GQDs.

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Enhancing the magnetic relaxivity of MRI contrast agents via the localized superacid microenvironment of graphene quantum dots

Cited by 50 publications

References 67 publications

Magnetic graphene quantum dots facilitate closed-tube one-step detection of SARS-CoV-2 with ultra-low field NMR relaxometry

Magnetic graphene quantum dots facilitate closed-tube one-step detection of SARS-CoV-2 with ultra-low field NMR relaxometry

Computational Biomaterials: Computational Simulations for Biomedicine

Planted Graphene Quantum Dots for Targeted, Enhanced Tumor Imaging and Long‐Term Visualization of Local Pharmacokinetics

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