Enhancing the Limit of Detection for Comprehensive Two-Dimensional Gas Chromatography (GC×GC) using Bilinear Chemometric Analysis

Fraga, Carlos G.; Prazen, Bryan J.; Synovec, Robert E.

doi:10.1002/(sici)1521-4168(20000301)23:3<215::aid-jhrc215>3.0.co;2-q

Cited by 62 publications

(51 citation statements)

References 41 publications

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“…The chemometric method utilizes the multivariate techniques, such as the generalized rank annihilation method (GRAM) (see e.g. Fraga et al, 2000). The accuracy, precision, and lower detection limit in the quantification can be improved using the GRAM method.…”

Section: Quantificationmentioning

confidence: 99%

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Comprehensive two-dimensional gas chromatography (GC × GC) measurements of volatile organic compounds in the atmosphere

et al. 2003

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Abstract.During the MINOS campaign in August 2001 comprehensive two-dimensional gas chromatography (GC×GC) was applied to the in situ measurements of atmospheric volatile organic compounds (VOCs) at the Finokalia ground station, Crete. The measurement system employs a thermal desorption unit for on-line sampling and injection, and a GC×GC separation system equipped with a flame ionization detector (FID) for detection. The system was optimized to resolve C 7 − C 14 organic components. Two-dimensional chromatograms from measurements of Finokalia air samples show several hundred wellseparated peaks. To facilitate peak identification, cartridge samples collected at Finokalia were analyzed using the same GC×GC system coupled with a time-of-flight mass spectrometer (TOF-MS). The resulting mass spectra were deconvoluted and compared to spectra from a database for tentative peak identification. About 650 peaks have been identified in the two-dimensional plane, with significant signal/noise ratios (>100) and high spectra similarities (>800). By comparing observed retention indices with those found in the literature, 235 of the identifications have been confirmed. 150 of the confirmed compounds show up in the C 7 − C 14 range of the chromatogram from the in situ measurement. However, at least as many peaks remain unidentified. For quantification of the GC×GC measurements, peak volumes of measured compounds have been integrated and externally calibrated using a standard gas mixture.

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Section: Quantificationmentioning

confidence: 99%

“…Apart from the thermal modulators, valve-based modulators can also be used to make GC×GC measurements (Bruckner et al, 1998;Fraga et al, 2000;Johnson et al, 2002). However, the valve-based modulators send only a part of the effluent from the first column to the second column because they use the so-called heart-cutting technique.…”

Section: Introductionmentioning

confidence: 99%

Comprehensive two-dimensional gas chromatography (GC × GC) measurements of volatile organic compounds in the atmosphere

et al. 2003

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“…Similarly, the issue of coelutions, although important for peak detection, was not considered herein, as neither the two-step nor watershed algorithm incorporates a solution for coelution. Other techniques have been developed for unmixing coeluted peaks, e.g., [11][12][13][14][15][16][17][18][19][20][21]. Step (2-Step) peak detection algorithms for peaks with parametric skew (s); first-column (x-dimension) peak-width standard deviation, σ x ; second-column (y-dimension) peak-width standard deviation, σ y ; and noise standard deviation, σ n .…”

Section: Resultsmentioning

confidence: 99%

Comparative analysis of peak-detection techniques for comprehensive two-dimensional chromatography

Latha

Reichenbach²,

Qing

2011

Journal of Chromatography A

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“…Como o algoritmo GRAM utiliza a bilinearidade do conjunto de dados multidimensionais, ele foi utilizado para verificar a reprodutibilidade de dados obtidos em equipamentos de GC × GC construídos em laboratórios de pesquisa. 49,52,53 A análise de fatores paralelos (PARAFAC, Parallel Factor Analysis) é o algoritmo mais utilizado no tratamento de dados gerados a partir de GC × GC, principalmente, por apresentar vantagem de segunda ordem e também devido à facilidade de uso e interpretação dos resultados. No algoritmo PARAFAC, a decomposição dos dados é feita em tríades, onde cada componente consiste de um vetor escore e dois vetores pesos e, idealmente, o número de componentes é igual ao número de espécies químicas.…”

Section: Quimiometria E Gc × Gcunclassified

Cromatografia gasosa bidimensional abrangente (GC × GC)

Pedroso¹,

Godoy²,

Fidélis³

et al. 2009

Quím. Nova

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Recebido em 23/11/07; aceito em 30/7/08; publicado na web em 18/12/08 COMPREHENSIVE TWO-DIMENSIONAL GAS CHROMATOGRAPHY (GC × GC). This paper presents the fundamental principles, instrumentation and selected applications of comprehensive two-dimensional gas chromatography (GC × GC). In this technique, introduced in 1991, two capillary columns are coupled and proper modulating interfaces continuously collect the eluate from the first column, transferring it to the second column. The result is a geometric increment in the chromatographic resolution, ensuring separation of extremely complex mixtures in time periods shorter or comparable to those of analysis using conventional gas chromatography and with better detectabilities and sensitivities.

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Enhancing the Limit of Detection for Comprehensive Two-Dimensional Gas Chromatography (GC×GC) using Bilinear Chemometric Analysis

Cited by 62 publications

References 41 publications

Comprehensive two-dimensional gas chromatography (GC × GC) measurements of volatile organic compounds in the atmosphere

Comprehensive two-dimensional gas chromatography (GC × GC) measurements of volatile organic compounds in the atmosphere

Comparative analysis of peak-detection techniques for comprehensive two-dimensional chromatography

Cromatografia gasosa bidimensional abrangente (GC × GC)

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