Sugarcane vinasse has been widely reported due to the improper management that pollutes the environment. In this study, a combined coagulation and sequencing batch bio lm reactor (SBBR) seems to be a novel improvement for the treatment of sugarcane vinasse. This research focused on the optimal conditions of coagulation and SBBR and determined the abatement e ciency of sugarcane vinasse in combined sequential wastewater treatment. The coagulation process destabilizes the colloids in the aggregation and separates the supernatant by sedimentation and ltration, resulting in the maximum COD reduction (79.0 ± 3.4%) and decolorization e ciency (94.1 ± 1.9%) under the optimum conditions. Sequencing batch reactor (SBR) is a ll-and-draw activated sludge system, whereas SBBR is an integrated SBR that suspends activated sludge and connects growth processes into a biocarrier-lled system. SBBR showed great synergistic degradability, decreasing 86.6 ± 4.3% COD concentration and 94.6 ± 3.8% decolorization at 3.0 g/L of substrate loading concentration. Furthermore, kinetic studies of SBBR revealed that the rst-order kinetic model was the best tting model. The SBBR reaction was further investigated by ultraviolet-visible spectrophotometry (UV-Vis). Then, SBBR followed by the coagulation process (SBBR-CP) achieved 97.5% of COD reduction and 99.4% of decolorization, which was better than the coagulation process followed by SBBR (CP-SBBR). This nding provides new insight into developing e cient combined sequential wastewater treatments in sugarcane vinasse.