Enhancing the blood response and antibacterial adhesion of titanium surface through oxygen plasma immersion ion implantation treatment

Shiau, Duen Kai; Yang, Chih Hsiung; Sun, Ying; Wu, Mei Fang; Pan, Haobo; Huang, Her Hsiung

doi:10.1016/j.surfcoat.2018.05.029

Cited by 15 publications

(5 citation statements)

References 29 publications

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“…In the current study, surface deposition (and the corresponding crystal phase formation) was shown not to have a significant effect on surface energy; however, we observed remarkable variability in the dielectric constant ε between the test Ti specimens, as follows: A group (25), R group (144), AR group (40), and T group (82). Our findings are in good agreement with those dielectric constants reported in previous papers: anatase phase (30~40) and rutile phase (100~170) [ 42 , 43 , 44 ]. One previous study reported that the high dielectric constant of crystalline TiO 2 films increases the van der Waals force to beyond that other TiO 2 oxides (e.g., TiO and Ti 2 O 3 ) [ 45 ].…”

Section: Resultssupporting

confidence: 93%

Blood Coagulation on Titanium Dioxide Films with Various Crystal Structures on Titanium Implant Surfaces

Huang

Chen

Nguyen

et al. 2022

Cells

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Background: Titanium (Ti) is one of the most popular implant materials, and its surface titanium dioxide (TiO2) provides good biocompatibility. The coagulation of blood on Ti implants plays a key role in wound healing and cell growth at the implant site; however, researchers have yet to fully elucidate the mechanism underlying this process on TiO2. Methods: This study examined the means by which blood coagulation was affected by the crystal structure of TiO2 thin films (thickness < 50 nm), including anatase, rutile, and mixed anatase/rutile. The films were characterized in terms of roughness using an atomic force microscope, thickness using an X-ray photoelectron spectrometer, and crystal structure using transmission electron microscopy. The surface energy and dielectric constant of the surface films were measured using a contact angle goniometer and the parallel plate method, respectively. Blood coagulation properties (including clotting time, factor XII contact activation, fibrinogen adsorption, fibrin attachment, and platelet adhesion) were then assessed on the various test specimens. Results: All of the TiO2 films were similar in terms of surface roughness, thickness, and surface energy (hydrophilicity); however, the presence of rutile structures was associated with a higher dielectric constant, which induced the activation of factor XII, the formation of fibrin network, and platelet adhesion. Conclusions: This study provides detailed information related to the effects of TiO2 crystal structures on blood coagulation properties on Ti implant surfaces.

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Section: Resultssupporting

confidence: 93%

Blood Coagulation on Titanium Dioxide Films with Various Crystal Structures on Titanium Implant Surfaces

Huang

Chen

Nguyen

et al. 2022

Cells

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“…PIII method and optical emission spectrometry (OES) was used to produce TiO 2 , which has the potential to improve the osseointegration of implants due to its super hydrophilicity (Lin et al, 2019). Shiau et al (2019) and Chen et al (2020) investigated the parameters of O-PIII respectively, the former proved that the applied voltage during O-PIII treatment promote bloodclotting and platelet activation, as shown in Figure 4, the latter indicates that the use of higher doses of oxygen ions can improve osteocytic differentiation and osseointegration of dental Ti implants in vivo. In addition to O-PIII, nitrogen plasma immersion ion implantation (N-PIII), carbon plasma immersion ion implantation (C-PIII), etc.…”

Section: Plasma Immersion Ion Implantationmentioning

confidence: 99%

Surface Modification Techniques of Titanium and its Alloys to Functionally Optimize Their Biomedical Properties: Thematic Review

Xue

Attarilar

Liu

et al. 2020

Front. Bioeng. Biotechnol.

134

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Depending on the requirements of specific applications, implanted materials including metals, ceramics, and polymers have been used in various disciplines of medicine. Titanium and its alloys as implant materials play a critical role in the orthopedic and dental procedures. However, they still require the utilization of surface modification technologies to not only achieve the robust osteointegration but also to increase the antibacterial properties, which can avoid the implant-related infections. This article aims to provide a summary of the latest advances in surface modification techniques, of titanium and its alloys, specifically in biomedical applications. These surface techniques include plasma spray, physical vapor deposition, sol-gel, micro-arc oxidation, etc. Moreover, the microstructure evolution is comprehensively discussed, which is followed by enhanced mechanical properties, osseointegration, antibacterial properties, and clinical outcomes. Future researches should focus on the combination of multiple methods or improving the structure and composition of the composite coating to further enhance the coating performance.

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“…After 6 h of incubation, it was observed that 70% of lesser bacteria adhered to the coated surface. Colonies found on the TH samples were lesser than 0.5 × 10 6 CFU/mL, and for control, the values were higher than 2.5 × 10 6 CFU/mL [228]. Plasma immersion ion deposition of biomaterial has several advantages and disadvantages, which are mentioned in the Table 17.…”

Section: And 60% Precursor Plasma Immersion Ion Depositionmentioning

confidence: 98%

Surface Engineering Strategies to Enhance the In Situ Performance of Medical Devices Including Atomic Scale Engineering

Sultana

Zare

Luo

et al. 2021

IJMS

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Decades of intense scientific research investigations clearly suggest that only a subset of a large number of metals, ceramics, polymers, composites, and nanomaterials are suitable as biomaterials for a growing number of biomedical devices and biomedical uses. However, biomaterials are prone to microbial infection due to Escherichia coli (E. coli), Staphylococcus aureus (S. aureus), Staphylococcus epidermidis (S. epidermidis), hepatitis, tuberculosis, human immunodeficiency virus (HIV), and many more. Hence, a range of surface engineering strategies are devised in order to achieve desired biocompatibility and antimicrobial performance in situ. Surface engineering strategies are a group of techniques that alter or modify the surface properties of the material in order to obtain a product with desired functionalities. There are two categories of surface engineering methods: conventional surface engineering methods (such as coating, bioactive coating, plasma spray coating, hydrothermal, lithography, shot peening, and electrophoretic deposition) and emerging surface engineering methods (laser treatment, robot laser treatment, electrospinning, electrospray, additive manufacturing, and radio frequency magnetron sputtering technique). Atomic-scale engineering, such as chemical vapor deposition, atomic layer etching, plasma immersion ion deposition, and atomic layer deposition, is a subsection of emerging technology that has demonstrated improved control and flexibility at finer length scales than compared to the conventional methods. With the advancements in technologies and the demand for even better control of biomaterial surfaces, research efforts in recent years are aimed at the atomic scale and molecular scale while incorporating functional agents in order to elicit optimal in situ performance. The functional agents include synthetic materials (monolithic ZnO, quaternary ammonium salts, silver nano-clusters, titanium dioxide, and graphene) and natural materials (chitosan, totarol, botanical extracts, and nisin). This review highlights the various strategies of surface engineering of biomaterial including their functional mechanism, applications, and shortcomings. Additionally, this review article emphasizes atomic scale engineering of biomaterials for fabricating antimicrobial biomaterials and explores their challenges.

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Enhancing the blood response and antibacterial adhesion of titanium surface through oxygen plasma immersion ion implantation treatment

Cited by 15 publications

References 29 publications

Blood Coagulation on Titanium Dioxide Films with Various Crystal Structures on Titanium Implant Surfaces

Blood Coagulation on Titanium Dioxide Films with Various Crystal Structures on Titanium Implant Surfaces

Surface Modification Techniques of Titanium and its Alloys to Functionally Optimize Their Biomedical Properties: Thematic Review

Surface Engineering Strategies to Enhance the In Situ Performance of Medical Devices Including Atomic Scale Engineering

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