Abstract:Cell-released nanovesicles can induce anti-leukemia immunity. Leukemia
cell-derived exosomes (LEXs) are promising anti-tumor vaccine components
for cancer immunotherapy. Nonetheless, LEX-based vaccines show modest
potency in vivo, likely due to the presence of immunosuppressive PD-L1
proteins in the exosomes. We hypothesized that targeting exosomal PD-L1
could optimize LEX-based vaccines. To test this hypothesis, we compared
the capacity of exosomes derived from PD-L1-silenced leukemia cells
(LEXPD-L1si) and n… Show more
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