Enhancing resistance and cell survival in Acipenser ruthenus liver, gill, and kidney cells: The potential of heat shock protein inducers against PAH-benzo[a]pyrene stress

Zarei, Sevda; Ghafouri, Hossein; Vahdatiraad, Leila; Heidari, Behrooz; Sohrabi, Tooraj

doi:10.1007/s11356-024-31884-3

Cited by 3 publications

(2 citation statements)

References 68 publications

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“… 50 According to several studies, survival and HSP expression are directly related to stress conditions. 41 , 51 , 52 As HSP chaperones play a crucial role in protecting cells against stress, we investigated whether HSPis could counteract the effects of salinity on A. ruthenus cells. To test this hypothesis, we used NOP, AMG, and SZ (a pirano-piranazole-derived compound, Supplementary Figure 1 ).…”

Section: Discussionmentioning

confidence: 99%

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The influence of HSP inducers on salinity stress in sterlet sturgeon (Acipenser ruthenus): In vitro study on HSP expression, immune responses, and antioxidant capacity

Zarei,

Ghafouri,

Vahdatiraad

et al. 2024

Cell Stress and Chaperones

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Section: Discussionmentioning

confidence: 99%

“…The International Sturgeon Research Institute provided a specimen of A. ruthenus measuring 18 cm in length and weighing 15.28 g. According to Zarei et al , 46 , 52 liver, gill, and kidney tissue cells were extracted and analyzed.…”

Section: Methodsmentioning

confidence: 99%

The influence of HSP inducers on salinity stress in sterlet sturgeon (Acipenser ruthenus): In vitro study on HSP expression, immune responses, and antioxidant capacity

Zarei,

Ghafouri,

Vahdatiraad

et al. 2024

Cell Stress and Chaperones

Self Cite

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Effects of HSP inducers on the gene expression of Heat Shock Proteins (HSPs) in cells extracted from sterlet sturgeon under temperature stress with antioxidant and immunity responses

Zarei,

Ghafoori,

Vahdatiraad

et al. 2024

Fish Physiol Biochem

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Potential of heat shock protein inducers in mitigating benzo[α]pyrene toxicity in stellate sturgeon fingerlings (Acipenser stellatus): Assessing the effects on CYP450 and AChE activity, HSP70 expression, antioxidant levels, cortisol, and immunological responses

Vahdatiraad,

Heidari,

Zarei

et al. 2024

J World Aquaculture Soc

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Benzo[α]pyrene (BαP), a polycyclic aromatic hydrocarbon (PAH), is a significant contaminant in the environment, which accumulates and is toxic to invertebrates and fish. The present study aimed to determine the acute toxicity of sublethal concentrations of BαP in the presence of the heat shock protein (HSP) inducer (HSPi) on CYP450 activity, HSP70 gene expression, antioxidant levels, immunological alterations, and AChE activity in stellate sturgeon fingerlings. Two‐hundred and forty fish were exposed to 100 mg L−1 of Nopal endurance (HSPi) for 4 h. In the next step, the fish were exposed to BαP concentrations equivalent to 25%, 50%, and 75% of the 96‐h LC50 values. Sampling was carried out on the first, third, and sixth days of the experiment, and the samples were analyzed using two‐way analysis of variance (ANOVA), cluster analysis (CA), and principal component analysis (PCA). The CYP450 activity significantly increased under BαP treatments. Higher expression of the HSP70 gene was observed in the higher concentration of HSPi + BαP treatments. The lowest AChE activity was observed in BαP treatments. However, the activity of superoxide dismutase, catalase, and total antioxidant activity enzymes and immunological responses (lysozyme, IgM, and C3) increased by using HSPi. It can be concluded that the HSP inducer significantly decreased BαP toxicity and resulted in more resistance to stress situations in sturgeon fingerlings.

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Enhancing resistance and cell survival in Acipenser ruthenus liver, gill, and kidney cells: The potential of heat shock protein inducers against PAH-benzo[a]pyrene stress

Cited by 3 publications

References 68 publications

The influence of HSP inducers on salinity stress in sterlet sturgeon (Acipenser ruthenus): In vitro study on HSP expression, immune responses, and antioxidant capacity

The influence of HSP inducers on salinity stress in sterlet sturgeon (Acipenser ruthenus): In vitro study on HSP expression, immune responses, and antioxidant capacity

Effects of HSP inducers on the gene expression of Heat Shock Proteins (HSPs) in cells extracted from sterlet sturgeon under temperature stress with antioxidant and immunity responses

Potential of heat shock protein inducers in mitigating benzo[α]pyrene toxicity in stellate sturgeon fingerlings (Acipenser stellatus): Assessing the effects on CYP450 and AChE activity, HSP70 expression, antioxidant levels, cortisol, and immunological responses

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