Enhancing regenerative medicine: the crucial role of stem cell therapy

Wang, Jipeng; Deng, Gang; Wang, Shuyi; Li, Shuang; Song, Peng; Lin, Kun; Xu, Xiaoxiang; He, Zuhong

doi:10.3389/fnins.2024.1269577

Cited by 4 publications

(2 citation statements)

References 126 publications

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“…Currently, the treatment of CNS diseases using cell-based approaches is rapidly expanding, especially approaches based on the use of stem cells [ 17 ]. At the same time, macrophages, namely macrophages of the M2 phenotype, represent another type of cell that plays a key role in the healing of various tissues, including the repair of nervous tissue, by reducing the detrimental effects of inflammatory factors and creating a microenvironment that promotes neuronal regeneration [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

Intranasal Immunotherapy with M2 Macrophage Secretome Ameliorates Language Impairments and Autistic-like Behavior in Children

Shevela,

Loginova,

Munkuev

et al. 2024

JCM

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Background/Objectives: The intranasal delivery of various neurotropic substances is considered a new attractive therapeutic approach for treating neuropathologies associated with neuroinflammation and altered regeneration. Specific language impairment (SLI) that arises as a result of damage to the cortical speech zones during the developmental period is one of the most common problems in preschool children, and it is characterized by persistent difficulties in the acquisition, understanding, and use of language. This study’s objective is to evaluate the efficacy and safety of intranasal immunotherapy using the M2 macrophage secretome as a rich source of immunoregulatory and neurotrophic factors for the treatment of severe language impairment in children. Methods: Seventy-one children (54 boys and 17 girls, aged 3 to 13 years) were recruited to participate in a clinical trial (NCT04689282) in two medical centers. The children were examined before, 1 month after, and 6 months after the start of therapy. In the vast majority of children (55/71), language impairment was associated with autistic-like symptoms and attention deficit hyperactivity disorder (ADHD). Results: Daily intranasal inhalations of M2 macrophage-conditioned medium (for 30 days) were well tolerated and led to a decrease in the severity of language impairments, autistic-like behavior, and ADHD symptoms. The clinical effect appeared within a month after the first procedure and persisted or intensified during a 6-month follow-up. Two-thirds of the children showed a clear clinical improvement, while the rest had less pronounced improvement. Conclusions: Thus, the use of the M2 macrophage secretome and its intranasal delivery is safe, well tolerated, and clinically effective in children with severe language impairments.

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Section: Discussionmentioning

confidence: 99%

Intranasal Immunotherapy with M2 Macrophage Secretome Ameliorates Language Impairments and Autistic-like Behavior in Children

Shevela,

Loginova,

Munkuev

et al. 2024

JCM

View full text Add to dashboard Cite

show abstract

“…Stem cells, as a therapeutic method, represent a paradigm shift in medicine that offers revolutionary potential in the treatment of various diseases and injuries (J. Wang et al, 2024 ). Stem cells are unique in their ability to self-renew and differentiate into specialized cell types, making them valuable tools for regenerative medicine and tissue engineering ( Jin et al, 2023 ).…”

Section: Challenges In Categorizing Stem Cells As Drugsmentioning

confidence: 99%

Stem cell therapy as a promising approach for ischemic stroke treatment

Yaqubi,

Karimian

2024

Current Research in Pharmacology and Drug Discovery

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Natural small molecules synergize mesenchymal stem cells for injury repair in vital organs: a comprehensive review

Qu,

Wang,

Dong

et al. 2024

Stem Cell Res Ther

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Mesenchymal stem cells (MSCs) therapy is a highly researched treatment that has the potential to promote immunomodulation and anti-inflammatory, anti-apoptotic, and antimicrobial activities. It is thought that it can enhance internal organ function, reverse tissue remodeling, and achieve significant organ repair and regeneration. However, the limited infusion, survival, and engraftment of transplanted MSCs diminish the effectiveness of MSCs-based therapy. Consequently, various preconditioning methods have emerged as strategies for enhancing the therapeutic effects of MSCs and achieving better clinical outcomes. In particular, the use of natural small molecule compounds (NSMs) as a pretreatment strategy is discussed in this narrative review, with a focus on their roles in regulating MSCs for injury repair in vital internal organs. Additionally, the discussion focuses on the future directions and challenges of transforming mesenchymal stem cell research into clinical applications.

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Enhancing regenerative medicine: the crucial role of stem cell therapy

Cited by 4 publications

References 126 publications

Intranasal Immunotherapy with M2 Macrophage Secretome Ameliorates Language Impairments and Autistic-like Behavior in Children

Intranasal Immunotherapy with M2 Macrophage Secretome Ameliorates Language Impairments and Autistic-like Behavior in Children

Stem cell therapy as a promising approach for ischemic stroke treatment

Natural small molecules synergize mesenchymal stem cells for injury repair in vital organs: a comprehensive review

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