Enhancing recombinant antibody yield in Chinese hamster ovary cells
Chee-Hing Yang,
Hui-Chun Li,
Shih-Yen Lo
Abstract:A range of recombinant monoclonal antibodies (rMAbs) have found application in treating diverse diseases, spanning various cancers and immune system disorders. Chinese hamster ovary (CHO) cells have emerged as the predominant choice for producing these rMAbs due to their robustness, ease of transfection, and capacity for posttranslational modifications akin to those in human cells. Transient transfection and/or stable expression could be conducted to express rMAbs in CHO cells. To bolster the yield of rMAbs in… Show more
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