Enhancing Protein Solubility via Glycosylation: From Chemical Synthesis to Machine Learning Predictions
Bo Ma,
Hedi Chen,
Jinyuan Gong
et al.
Abstract:Glycosylation is a valuable tool for modulating protein solubility; however, the lack of reliable research strategies has impeded efficient progress in understanding and applying this modification. This study aimed to bridge this gap by investigating the solubility of a model glycoprotein molecule, the carbohydratebinding module (CBM), through a two-stage process. In the first stage, an approach involving chemical synthesis, comparative analysis, and molecular dynamics simulations of a library of glycoforms wa… Show more
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